196,046 research outputs found
Kustaanheimo-Stiefel Variables to Halve the Cost of Monte Carlo Planetary Protection Compliance Analysis
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A torsion-based solution to the hyperbolic regime of the J2-problem
Get PDFA popular intermediary in the theory of artificial satellites is obtained after the elimination of parallactic terms from the J2-problem Hamiltonian. The resulting quasi-Keplerian system is in turn converted into the Kepler problem by a torsion. When this reduction process is applied to unbounded orbits, the solution is made of Keplerian hyperbolae. For this last case, we show that the torsion-based solution provides an effective alternative to the Keplerian approximation customarily used in flyby computations. Also, we check that the extension of the torsion-based solution to higher orders of the oblateness coefficient yields the expected convergence of asymptotic solutions to the true orbit
Combined B-Plane and Picard-Chebyshev Approach for the Continuous Design of Perturbed Interplanetary Resonant Trajectories
Get PDFOrbital Resonance Analysis in Monte Carlo Simulations for Planetary Protection and Defence
No full textFree radicals promote "in vitro" a different intracellular decay of rabbit reticulocyte and erythrocyte glycolytic enzymes
No full textIntemational Symposium on Red Blood CelI Agi
Human recombinant lysozyme downregulates advanced glycan endproduct-induced interleukin-6 production and release in an in vitro model of human proximal tubular epithelial cells
No full textDiabetic nephropathy is the leading cause of chronic renal disease and one of the major causes of cardiovascular mortality.
Evidence suggests that its progression is due to the chronic hyperglycemia consequent to the production and accumulation of
advanced glycation endproducts (AGEs). Lysozyme was shown to posses AGE-sequestering properties and the capacity to
reduce the severity of the early stage manifestations of the diabetic nephropathy. This study was aimed to contribute to the
understanding the molecular mechanisms of lysozyme effectiveness in the diabetic nephropathy, using an in-vitro cellular model,
represented by the HK-2 cells, human proximal tubular epithelial cells. Lysozyme significantly reduced the AGE-induced IL-6
mRNA and an ELISA assay showed also a decreased release of the functional protein with a dose-dependent trend. In addition,
lysozyme prevented macrophage recruitment, suggesting its capacity to elicit an anti-inflammatory action. We may conclude that
the protective action of lysozyme on the nephrotoxic effects of AGE may depend, at least in part, on its ability to prevent the
production and release of inflammatory mediators, such as IL-6 and to reduce macrophage recruitment in the inflammatory sites
C1q is responsible of the anti-inflammatory behavior of decidual endothelial cells
No full textPROBLEM: Endothelial cells (ECs), although similar in function and morphology, represent an heterogeneous population of cells in terms of secretion of inflammatory mediators, modulation of adhesion molecules, leakiness and pro-coagulant activity and play a fundamental role in the control of the inflammatory response. Excessive inflammation at foetal-maternal interface is thought to be a key contributor in a compromised pregnancy. Intrauterine infections have been associated with pregnancy complications such as preterm labor, intrauterine growth restriction and preeclampsia.
We demonstrated that decidual endothelial cells (DECs) compared to ECs isolated from adult skin (ADMECs) are ipo-responsive to the pro-inflammatory stimulus LPS for the expression of adhesion molecules and cytokines secretion. We showed also that DECs express lower level of TLR4, MD2 and MyD88 compared to ADMECs and this may be important for the control of the inflammatory response at foeto-maternal interface.
We have previously shown that DECs acquired the ability to synthesize C1q during pregnancy which is to a large extent localized on the cell surface. Since it has been demonstrated that C1q suppressed LPS-induced IL-12p40 production in bone marrow-derived DC (BMDC) we hypothesised that C1q can play a role in the control of DECs response to LPS.
METHODS: We investigated the expression of TLR4, MD-2, and MyD88 in ADMECs previously incubated for two hours with C1q in cells stimulated or not with LPS by Real Time PCR, Western blotting and cytofluorimetric analysis.
RESULTS: Our results showed that C1q affects mRNA expression of TLR4, MD-2, and MyD88 both in resting and in stimulated cells,
CONCLUSION: The presence of C1q at foeto maternal interface may be responsible of the control of inflammation during pregnancy
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