218 research outputs found
Angiogenesis in cancer
No full textNaoyo Nishida1,2, Hirohisa Yano1, Takashi Nishida3, Toshiharu Kamura2, Masamichi Kojiro1Departments of 1Pathology and 2Obstetrics and Gynecology and Research Center of Innovative Cancer Therapy of the 21 Century COE Program for Medical Science, Kurume University School of Medicine, Fukuoka, Japan; 3Hita Saiseikai Hospital, Oita, JapanAbstract: New growth in the vascular network is important since the proliferation, as well as metastatic spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the removal of waste products. New blood and lymphatic vessels form through processes called angiogenesis and lymphangiogenesis, respectively. Angiogenesis is regulated by both activator and inhibitor molecules. More than a dozen different proteins have been identified as angiogenic activators and inhibitors. Levels of expression of angiogenic factors reflect the aggressiveness of tumor cells. The discovery of angiogenic inhibitors should help to reduce both morbidity and mortality from carcinomas. Thousands of patients have received antiangiogenic therapy to date. Despite their theoretical efficacy, antiangiogeic treatments have not proved beneficial in terms of long-term survival. There is an urgent need for a new comprehensive treatment strategy combining antiangiogenic agents with onventional cytoreductive treatments in the control of cancer.Keywords: angiogenesis, immunohistochemistry, prognosi
Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation
No full text博士(医学) 甲第744号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Tatsuya KOBAYASHI, Makoto MIYAZAKI, Nobuyoshi SASAKI, Shun YAMAMURO, Eita UCHIDA, Daisuke KAWAUCHI, Masamichi TAKAHASHI, Yohei OTSUKA, Kosuke KUMAGAI, Satoru TAKEUCHI, Terushige TOYOOKA, Naoki OTANI, Kojiro WADA, Yoshitaka NARITA, Hideki YAMAGUCHI, Yoshihiro MURAGAKI, Takakazu KAWAMATA, Kentaro MORI, Koichi ICHIMURA, Arata TOMIYAMA，タイトル:Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation，掲載誌:Cancers(2072-6694)，巻・頁・年:12巻12号 p.3641(2020)，著作権関連情報:© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).，DOI:10.3390/cancers1212364
Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation
No full text東京女子医科大学博士(医学)博士(医学) 甲第744号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Tatsuya KOBAYASHI, Makoto MIYAZAKI, Nobuyoshi SASAKI, Shun YAMAMURO, Eita UCHIDA, Daisuke KAWAUCHI, Masamichi TAKAHASHI, Yohei OTSUKA, Kosuke KUMAGAI, Satoru TAKEUCHI, Terushige TOYOOKA, Naoki OTANI, Kojiro WADA, Yoshitaka NARITA, Hideki YAMAGUCHI, Yoshihiro MURAGAKI, Takakazu KAWAMATA, Kentaro MORI, Koichi ICHIMURA, Arata TOMIYAMA，タイトル:Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation，掲載誌:Cancers(2072-6694)，巻・頁・年:12巻12号 p.3641(2020)，著作権関連情報:© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).，DOI:10.3390/cancers12123641doctoral thesi
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