1,721,044 research outputs found
SYNTHESIS, CHARACTERISATION, CHEMISTRY AND PHOTOCHEMISTRY OF A FAMILY OF RUTHENIUM DIHYDRIDE COMPLEXES
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Synthesis, characterization and antiproliferative activity of amino- and DMSO complexes of platinum(II) containing L-carnitine
No full textL-Carnitine, a biomolecule able to cross the blood-brain barrier exploiting specific transporters, behaves as mono or bidentate anionic ligand for Pt(II) in the new amino complexes cis-[Pt(L-carnitine-O)2(NH3)2](BF4)2 (1), cis-[PtCl(L-carnitina-O)(NH3)2]BF4 (2), [Pt(L-carnitine-O,O’)(1,2-DACH)]BF4 (3), [Pt(L-carnitine-O)2(1,2-DACH)](BF4)2 (4), and [PtCl(L-carnitine-O)(1,2-DACH)](BF4) (5). Four complexes with DMSO have been also prepared and characterized: the synthetic intermediate [Pt(CO3)(DMSO)2] (6), [Pt(L-carnitine-O,O’)(DMSO)2]BF4 (7), cis-[Pt(L-carnitine-O)2(DMSO)2](BF4)2 (8) and cis-[PtCl(L-carnitine-O)(DMSO)2]BF4, (9).
The antiproliferative activity of three representative complexes 1, 5 and 7 has been assayed against three human cancer cell lines A2780, K562 and SKOV3, and it was found comparable to that of the parent active compounds cis-[PtCl2(1,2-DACH)] and cisplatin
Nitrido-Technetium(V) Complexes with Amino Acids: Preparation and X-ray Crystal Structure of the l-Cysteinate Ethyl Ester Technetium(V) Complex
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99Tc≡N/ 99mTc≡N-complexes with aminoacids, synthesis, and crystal structure of [ 99TcNCl (CYS-OEt) (PPh 3)]
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Structural features of the intermolecular interactions between PTA and nutraceutical acids in salts and platinum complexes
Full text linkThe cage-like phosphine 1,3,5-triaza-7-phosphaadamantane (PTA) is attracting a lot of attention in coordination chemistry due to its favorable properties like stability to oxidation, small dimensions, solubility in water. Actually, Ru, Pd, Pt, Au,Ag complexes containing PTA are under investigation for aqueous phase or biphasic homogeneous catalysis, anticancer activity, photoluminescence experiments as well as crystal engineering. PTA molecule has a basic character, and it undergoes a selective nitrogen protonation, while the preferred coordination site is
phosphorus. However, unlike the related compound hexamethylenetetramine, PTA salts have been reported so far. We have therefore undertaken a systematic synthetic-structural study on PTA- nutraceutical acids salts, aimed at exploring the structural features of the interactions between the
different molecules
Technetium and rhenium carbonyl complexes with 1,4-benzodiazepine derivatives: X-ray crystal structure
No full textTechnetium and rhenium carbonyl complexes [M(CO)2(PPh3)2(L)] (HL = 1,4-benzodiazepine-2-ones-4-oxide and 1,4-benzodiazepine-2-thiones) were prepared and characterized by FT-IR, NMR and elemental analysis. In these complexes the ligands are coordinated through the deprotonated N(1) and C(2) = X (X = O, S) atoms. The X-ray crystal structure was determined for the complex [Tc(CO)2(PPh3)2(1,2)] (HL2 = 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-4-oxide). The metal ion is in an octahedral environment coordinated to two triphenylphosphines in apical positions, two cis CO groups in trans to nitrogen and oxygen atoms from the ligand to form the basal plane. The boat conformation of the seven-membered ring of the ligand is maintained in the complex. © 1998 Elsevier Science S.A. All rights reserved
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