1,721,148 research outputs found

    Iron Defi ciency in Infancy and Childhood

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    Iron defi ciency is the most common cause of anemia in all age groups and can be associated with signifi cant shortand long-term morbidity. Prevention is achieved by prolonged breast feeding, avoidance of cows milk and unfortifi ed formulas, and the introduction of complementary foods at about 6 months. Ideally, complementary foods should be fortifi ed with iron and vitamin C. There is consensus on thedevelopmental adverse consequences of iron deficiency, although the short-term benefi ts of therapy are not clearly established. Prophylaxis should be limited to infants who are at high risk of developing iron deficiency. The routine provision of iron supplements can be detrimental in non-iron-defi cient children. Iron therapy should be given orally when possible and continued for several months after the correction of anemia in order to replenish the body iron stores. Special attention should be paid to the socioeconomically disadvantaged groups in industrialized countries and to children in developing countries

    Transfusional iron overload and iron chelation therapy in thalassemia major and sickle cell disease

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    KEY POINTS Thalassemia major is caused by defects in the synthesis of one or more of the globin subunits of hemoglobin, resulting in variable phenotypes. The yearly incidence of symptomatic individuals is estimated at 1 in 100,000 people throughout the world (22,989 new births) and 1 in 10,000 people in the European Union. Patients with thalassemia, being transfusion-dependent and having a hyperactive marrow, accumulate iron in tissues. The worldwide birth rate of individuals with symptomatic sickle cell disease (SCD) is approximately 2.2 per 1000 births. However, the disease incidence varies between ethnic groups. Blood transfusions may be required in both acute and chronic complications of SCD. SCD and thalassemia major differ in iron-loading patterns and in the prevalence of ironinduced organ damage

    Unilateral asymptomatic testis enlargement in children and adolescents

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    In literature a well codified definition of unilateral asymptomatic testis enlargement does not exist. Therefore in these cases the pediatrician or adolescentologist will have to make a clinical and diagnostic evaluation in order to exclude: a) an enlarged testis secondary to tumors, surgery, or endocrinological diseases; b) a small testis due to a previous (ex. cryptorchidism) or current disease (e.g. varicocele).The presence of a mild difference in testis volumes during puberty is not at all rare. This situation may be due to the technique used for evaluation of testis volume or secondary to a varicocele. The identification of variants of testis enlargement is important, because, while on one hand there are conditions without clinical relevance, on the other hand, there are diseases that require early diagnosis and immediate treatment. The Authors report a brief review of the literature and their own clinical experience. 14 patients with unilateral testis enlargement were observed. At the first examination, mean age was 12.3±1.2 years and the volume of the enlarged testis varied between 4 ml and 20 ml (mean volume 10±4 ml) versus 1.5 ml and 10 ml (mean volume 5±2 ml) of the contralateral testis. In 75% of cases the right testis was affected. During the ten year follow-up, the volume of the enlarged testis never exceeded 25 ml and progressive reduction of the difference between the two testes was demonstrated. Therefore, they propose another clinical condition defined as transitory unilateral testis enlargement of puberty
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