1,721,292 research outputs found
Prognostic difference between eastern and western patients with gastric cancer: Quality of care, ethnicity, or biology?
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ASO author reflections: gastric cancer with synchronous peritoneal disease-a clinically meaningful survival after CRS and HIPEC in selected patients from Italian peritoneal surface malignancies oncoteam network
No full textEthnicity-related differences in tumor immunity: A new possible explanation for gastric cancer prognostic variability?
No full textFamilial gastric cancer and germline mutations of E-cadherin
No full textBACKGROUND:
Most gastric cancer (GC) is sporadic and seem to be mostly related to a cumulative effect of multiple environmental factors. Although the actual importance of genetic factors has not yet been fully documented, GC with familial aggregation has been found to have an incidence of 10% to 30%.
MATERIALS AND METHODS:
Genetic factors contribute to the well-known autosomal dominant syndrome defined as hereditary diffuse gastric cancer (HDGC) which can be related to germline mutations of the gene encoding E-cadherin gene (CDH1). It has been estimated that 1-3% of cases of GC are due to HDGC.
DISCUSSION AND CONCLUSION:
The authors review data on CDH1 mutations in HDGC ,CDH1 testing criteria, and treatment. They conclude that cancer pedigrees and screening for CDH1 mutations are essential for improving the management of this disease
Focus on research: Nodal dissection for gastric cancer – A dilemma worthy of King Solomon!
No full textGastric cancer prognosis: strong correlation between incidence and survival.
No full textSeveral studies previously reported better outcome in Asian Americans when compared with other ethnicities, and these findings are confirmed in recent reports. The explanation for this phenomenon is unknown. Even if molecular studies on Eastern and Western patients have been conducted, potential biological differences between patient cohorts are still unclear. We could suppose that
two different biological entities of gastric cancer may exist: one with a low but uniform incidence throughout the world and higher biological aggressiveness, and a second form with wide variability in incidence and better prognosis. In low-risk areas, the higher relative proportion of the first form could explain the worse outcome with respect to geographic areas with higher incidence and proportion of the second form. These biological differences may be limited to noncardia tumors, and may be related to environmental factors acquired in youth
Patologie del duodeno
No full textL’ulcera duodenale è una patologia molto diffusa, dovuta ad una rottura dell’equilibrio tra fattori aggressivi e protettivi della mucosa. È caratterizzata da una tipica sintomatologia dolorosa, e può andare incontro a complicanze quali sanguinamento, perforazione e stenosi.
La diagnosi si esegue mediante EGDS; la terapia è prevalentemente di tipo medico, mentre le opzioni chirurgiche sono riservate ai casi refrattari o alla insorgenza di complicanze.
I diverticoli duodenali sono prevalentemente asintomatici. In circa l’1% dei casi vanno incontro a complicanze, che si associano a quadri clinici complessi sia dal punto di vista diagnostico che terapeutico a causa della frequente localizzazione periampollare del diverticolo.
I tumori duodenali maligni sono in prevalenza adenocarcinomi; meno frequenti sono le neoplasie mesenchimali, i tumori neuroendocrini ed i linfomi. Il quadro clinico può essere differente a seconda dell’istotipo. La diagnosi e la stadiazione della neoplasia si effettuano mediante EGDS e metodiche di imaging (TC, RM, ecoendoscopia). Più complessa risulta la diagnosi dei NET, a causa delle dimensioni spesso molto ridotte e della presenza di possibili lesioni multiple. Anche il trattamento chirurgico può variare a seconda del tipo istologico, il che rende importante la definizione preoperatoria del tipo di neoplasia
Proper selection and classification criteria are necessary in the evaluation of the new TNM staging system for gastric cancer
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