77,944 research outputs found
Reductive nitrosylation of the cardiolipin-ferric cytochrome c complex
No full textNative horse heart cytochrome c (cytc) displays a very low reactivity toward ligands and does not exhibit catalytic properties. However, upon bovine cardiolipin (CL) binding, cytc achieves myoglobin-like properties. Here, NO binding to CL-cytc(III) between pH 7.2 and 9.5, at 20 °C, is reported. At pH 7.2, CL-cytc(III) undergoes reversible nitrosylation, whereas between pH 7.9 and 9.5 CL-cytc(III) undergoes irreversible reductive nitrosylation leading to the formation of CL-cytc(II)-NO. Over the whole pH range explored, first-order kinetics of NO binding to CL-cytc(III) (k = 9.3 s(-1) ) indicates that ligand binding is limited by the cleavage of the weak heme-Fe distal bond. Between pH 7.9 and 9.5, nitrosylated CL-cytc(III) converts to the ligand-free ferrous derivative (CL-cytc(II)), this process being pH-dependent (hOH- = 3.0 × 10(3) M(-1) s(-1) ). Then, CL-cytc(II) converts to nitrosylated CL-cytc(II), in the presence of NO excess. The value of the second-order rate constant for CL-cytc(II) nitrosylation is essentially pH-independent, the average value of lon being 1.4 × 10(7) M(-1) s(-1) . These results agree with the view that CL-cytc nitrosylation may play a role in apoptosis regulation
Galileo e l'Inquisizione : memorie storico-critiche dirette alla romana Accademia di Archeologia / da monsignor Marino Marini
No full textGalileo e l'Inquisizione : memorie storico-critiche dirette alla romana Accademia di Archeologia / da monsignor Marino Marini
Roma : S. C. De propaganda fide, 1850
153 p. ; 22 c
54esima Biennale di Venezia - Padiglione della Repubblica di San Marino
No full textTitolo del progetto: "Luce In-azione"
Artisti: Dorothee Albrecht, Marco Bravura, Cristian Ceccaroni, Daniela Comani, Ottavio Fabbri, Verdiano Manzi, Patrizia Merendi, Omar Paolucci, Cristina Rotondaro, Lars Teichmann, Thea Tini, Daniela Tonelli, Paola Turroni
Commissario: Leo Marino Morganti.
Curatore: Valerio Pradal
Comitato scientifico e di selezione delle opere:
A. Bassi
F. Cavallari
M. Comoglio
L. Guerrini
M. G. Riva
R. Stih
C. Tartarin
Marchesi e altri lettori novecenteschi di Seneca. Proposte per una didattica attuale
No full textLe contraddizioni, evidenti in particolare in alcune opere, come la Consolatio ad Polybium e l'Apocolocyntosis, hanno costituito fin dal '700 un problema per gli studiosi di Seneca. Il lavoro prende in esame alcuni interpreti del '900, a partire dai fondamentali lavori di Concetto Marchesi, per arrivare a letture ideologiche come quelle di M. Zambrano, G. Grass, M. Hubay, G. Papini, che mostrano comunque una rivalutazione novecentesca del moralista di Cordova dallo stile lapidario, citato ad esempio anche da un autore d'aforismi come G. Pontiggia
Correction to: A T-junction device allowing for two simultaneous orthogonal views: application to bubble formation and break-up (Microfluidics and Nanofluidics, (2018), 22, 8, (85), 10.1007/s10404-018-2101-1)
No full textThe article ‘A T-junction device allowing for two simultaneous orthogonal views: application to bubble formation and break-up’, written by Davide Caprini, Giorgia Sinibaldi, Luca Marino, Carlo Massimo Casciola was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 30 July 2018 without open access
Morphological patterns at river contractions
No full textAbstract: Sediment transport at river contractions is an important process of engineering concern
which might occur when a river encounters a reduction in flow area because of either natural or
artificial constraints. This paper focuses on the morphological patterns that are prone to form at and
around the constriction of watercourses based on experimental investigations at laboratory scale.
Experiments were carried out at the University of Basilicata, Italy, in a 1 m wide and 20 m long
rectangular channel. The length of the working section extended up to 16 m, according to the length
of the contraction model. Two nearly-uniform sediments were used as mobile bed, sand with median
grain size d50 = 1.7 mm and gravel with d50 = 9.0 mm. The contraction length was either 0.5, 1.0, 2.0 or
3.0 m. Runs were carried out under steady flow and clear-water approach flow conditions. Typically,
they were of long duration (up to 15 days) also to achieve an equilibrium state. New predictive
equations are given on the temporal progress of: the maximum scour depth, the scour hole length,
and the axial bed profile with emphasis on the processes of bed aggradation or degradation beyond
the contracted region
Temporal scour evolution at non-uniform bridge piers
No full textScour at uniform cylindrical piers has received considerable attention in the past. However, bridge foundations can be subjected to the flow due to single or combined effects of long-term riverbed degradation, lateral shifting of the stream, contraction scour, local scour or other factors. This paper focuses on bed morphology changes due to local scour at piers founded on piles or caissons when the foundation is located at the initial bed level. Experiments were carried out in a 1 m wide 20 m long rectangular channel under clear-water and steady flow conditions. The majority of runs were of long duration in order to guarantee sufficient interaction between the flow and pier foundation and to approach the equilibrium phase. Two nearly uniform bed sediments were considered to assess grain size effects. The experimental data obtained provided new information on the temporal variation of scour depth, the areal extent of the scour hole and the scour volume, which are useful for validation of advanced numerical models. In this paper, scour depths are compared with the HEC-18 approach and agreements appear suitable only at the equilibrium phase. Moreover, scour progress is compared to that of uniform cylindrical piers and foundation effects are emphasised. A generalised scour equation is proposed, accounting for such effects
L' Adone, poema
No full textdel cavalier Marino ; con gli argomenti del conte Fortuniano Sanvitale et l'allegorie di don Lorenzo ScotoA c. *1r, in francese: Lettre ou Discours de M. ChapelainStemma calcogr. di Louis XIII sul front.Iniziali xil. figurate, testatine, fregiImpronta: oai- e-re i.ti RaRe (3) 1623 (R
Hepatitis C virus infection and autoimmune diseases
No full textMarino Paroli,1 Gino Iannucci,2 Daniele Accapezzato21Department of Biotechnology and Medical-Surgical Sciences, 2Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, ItalyAbstract: Hepatitis C virus (HCV) infection is associated with a number of extrahepatic disorders. The most studied conditions associated with HCV are type II mixed cryoglobulinemia and B cell lymphoma. However, many reports suggest that HCV might also be associated with a number of autoimmune disorders, both organ-specific and not organ-specific. Although concomitant treatment of HCV infection is a confounding factor when ascertaining the actual role of HCV in inducing autoimmune disease, a considerable amount of experimental data indicates that HCV is able to subvert the immune system and consequently induce autoimmunity. In the present review, we report a series of observations which associate chronic HCV infection with the onset of autoimmune disorders.Keywords: hepatitis C virus, immune regulation, autoimmune disease
Le nuove sfide del Progetto Urbano nell'era della crisi climatica
No full textL’innalzamento del livello del mare rappresenta uno degli effetti più impattanti dei cambiamenti
climatici sul territorio, con particolare riferimento all’area mediterranea.
Le strategie di adattamento rappresentano un approccio complementare alla mitigazione al fine di
perpetrare uno sviluppo urbano sostenibile e resiliente delle città costiere.
In questo senso, le amministrazioni locali, accanto alla definizione di vision strategiche, individuano
nella procedura del Progetto Urbano lo strumento più idoneo per rispondere alle nuove sfide della
contemporaneità.
Il contributo evidenzia la necessità, per i policy maker, di incentivare la costruzione di banche dati
complete ed esaustive per una puntuale valutazione della vulnerabilità dei territori ai diversi impatti
dei cambiamenti climatici come azione preliminare ad interventi progettuali site specific
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