1,721,042 research outputs found
VARIAZIONI TEMPORALI DELLE DIFFERENZE DI GENERE NELLE CARATTERISTICHE DELL’ABITUDINE AL FUMO TRA GLI OPERATORI SANITARI DI UN’AZIENDA OSPEDALIERA DEL CENTRO ITALIA
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RUOLO DELLE CHINESINE MITOTICHE COME POTENZIALE MARCATORE DI ESPOSIZIONE AD ASBESTO E PATOLOGIA ASBESTO-CORRELATA
No full textIl monitoraggio dei parametri vocali degli insegnanti
No full textIl rumore prodotto dalle voci e dalle attività dei bambini, incrementato dall'eccessiva riverberazione nelle aule, espone gli insegnanti a rischio di eccessivo sforzo e carico vocale
FLOGOSI DELLE VIE AEREE IN UN GRUPPO DI ADDETTI ALLE PULIZIE OSPEDALIERE ESPOSTO A SOSTANZE DISINFETTANTI E DETERGENTI
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Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals
No full textA dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above unwanted property for New Chemical Entities. The dataset was rationally split into training and test sets by means of a sphere-exclusion type algorithm. Among the many algorithms explored to search regression models, only a Support Vector Machine (SVM) method led to a QSAR model, which was proved to pass rigorous validation criteria, in accordance with the OECD guidelines. The proposed model is capable to explain the hepatocarcinogenic toxicity and could be exploited for predicting this property for chemicals at the early stage of their development, so optimizing resources and reducing animal testing
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