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Thalamic astrocytic hamartoma and associated meningoangiomatosis in a German shepherd dog
No full textThe present paper describes an astrocytic thalamic hamartoma associated with tectal meningoangiomatosis in a 3-month-old female German shepherd dog showing strabismus, opistotonus, circling, and fore limb hypermetria. MR images of the brain showed a well-defined intra-axial mass in the tectal region. The mass was hypointense to gray matter on T2-weighted images and hyperintense to gray matter on precontrast T1-weighted images. Histologically, glial cells arranged in a multinodular pattern characterized the mass. More caudally the lesion merged with subpial abnormal newly formed plaque-like shaped tissue characterized by thick branching bundles of spindle-shaped cells surrounding a central vessel. In the nodules, GFAP and vimentin were diffusely expressed. In the vascular proliferation Factor VIII-positive reaction was limited to endothelial cells while the remaining spindle-shaped cells were diffusely SMA-positive. The glial nodules did not express lysozyme and MAC387, nor neurofilaments and nestin
Histochemical cellular findings of enzootic intranasal tumour of goat - Preliminary investigations
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Primary Diffuse Leptomeningeal Gliomatosis in two dogs
No full textClinical, neuroimaging, and neuropathological findings of 2 cases of canine primary diffuse leptomeningeal gliomatosis are described. Magnetic resonance imaging and histopathological examination of the brain revealed diffuse leptomeningeal alterations with no parenchymal involvement. These cases share many similarities with the same disease in humans
Immunoexpression of epithelial membrane antigen in canine meningioma: Novel results for perspective considerations
No full textEpithelial membrane antigen (EMA) is one of the most widely used diagnostic immunohistochemical
markers for human meningioma. To date, no published study on
EMA expression in formalin-fixed paraffin-embedded (FFPE) tissue samples of canine
meningioma is available. Here, we describe the results of an immunohistochemical
study on 25 FFPE canine meningiomas using a monoclonal anti-human EMA antibody.
All meningiomas showed positive staining for EMA with cytoplasmic pattern, in
nine cases associated with membranous staining. Area and intensity of staining were
highly variable among cases. No clear relationships between tumour subtype/grade
and area/intensity of staining were found. However, epithelial-like patterns showed
a higher affinity for EMA compared to the mesenchymal one. The present study provides
the basis to explore the potential diagnostic application of this marker in canine
meningioma. To investigate EMA expression in other central nervous system tumours
of dogs are necessary to assess the specificity of this marker
Equine peritoneal mesothelioma: clincal, anatomohistopatological and ultrastructural studies
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