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Choroid plexus cyst, corticocerebral necrosis and hydrosyringomyelia in a dog
No full textA twenty-month-old Springer Spaniel presented with a history of episodic left head tilt appeared after physical effort six months before. The dog received oral prednisolone 0.8 mg/kg SID with slight improvement.
After the neurological examination a cervical spinal cord/posterior fossa localization was suspected. When the prednisolone treatment was tapered off the neurological status deteriorated and was consistent with a diffuse cerebral localization. The magnetic resonance imaging of the brain revealed a well-defined mass (cm 1,7x1,2x2,3) within the fourth ventricle, hyperintense on T2-weighted images (T2WI) and hypointense on pre and post contrast T1-weighted images (T1WI); in T2WI a severe, diffuse, poor defined cortical hyperintensity in both cerebral hemispheres and in the dorsocaudal part of the cerebellar vermis. These areas were mildly hypointense in T1WI and enhanced diffusely on post-contrast T1WI. T2WI of the cervical spine showed a severe hydrosyringomyelia and a diffuse hyperintensity of the spinal cord.
Histophatological investigation confirmed a widespread bilateral and symmetrical necrosis of cortical grey matter, a focal cystic lesion in the fourth ventricle consistent with a choroid plexus cyst (CPC), and a marked dilation of the central canal of the cervical spinal cord with two adjacent syrinx (hydrosyringomyelia).
To our knowledge this is the first case reporting in the same patient two rare conditions as diffuse cerebrocortical necrosis and CPC. We suspected a peracute worsening of a chronic impairment in cerebrospinal fluid flow at the foramen magnum, due to the CPC, and a sudden increase of the intracranial pressure causing a diffuse ischaemic lesion of the cerebral cortex
INFEZIONE SPERIMENTALE DELLA MAMMELLA CON S.AUREUS IN PECORE: MODIFICAZIONI DI ALCUNE ATTIVITÀ ENZIMATICHE NEL SIERO DI SANGUE, NEL SECRETO E TESSUTO MAMMARIO NELLE PRIME 48 ORE.
No full textIn pecore infettate sperimentalmente per via diatelica con un ceppo di S.aureus ed in animali controllo sono state valutate le attività enzimatiche di GGT, GOT, LDH, ICDH, CK e AlP nel siero di sangue e nel secreto mammario ad 8, 24, 32 e 48 ore dall'infezione, nonchè nel tessuto mammario a 48 ore. Le modificazioni dei valori delle attività esaminate sono state raffrontate con i rilievi dell'esame di ispezione e palpazione della mammella, con quelli dell'esame fisico-chimico e citobatteriologico del secreto, nonchè con i reperti anatomo-istopatologici ed ultrastrutturali della ghiandola mammaria. L'analisi dei risultati ottenuti ha permesso di evidenziare correlazioni significative tra l'andamento delle attività enzimatiche valutate ed i reperti anatomo-istopatologici.
GOT, GOT, LDH, ICDH, CK and AlP activities have been evaluated in experimentally infected sheeps for the teat canal in blood serum and udder secretum after 8, 24, 32, and 48 hours and in udder tissue after 48 hours from infection. The same activities were also evaluated with the same protocol' in a control group. Changes in the above mentioned activities were compared with clinical findings, somatic cells count, bacteria investigations and anatomic-pathological and ultrastructural reports of mammary gland. The analysis of results showed correlations between alterations of enzymatic activities and anatomic-pathological specimens
Il carcinoma a cellule squamose del cavallo. Indagine retrospettiva (1990-1998) e follow up a breve termine.
No full textA spinal cord giant cell tumor suggesting a meningioma with neuroendocrine differentiation in a cat.
No full textClinical, magnetic resonance imaging, and histopathologic features of a hypoglossal malignant peripheral nerve sheath tumor in a maltese dog
Full text linkMalignant tumours arising from peripheral nerves or displaying differentiation along the lines of the various elements of the nerve sheath are collectively referred to as MPNSTs. Histologically, in human MPNST, the malignant nature of these tumours is associated with an infiltrative and cellular proliferation of atypical, mitotically active spindle cells. Their predilection for sites varies with the species. In dogs the most common site for MPNST is the nerve roots or nerves of the brachial plexus, while the cranial nerve more frequently involved is the trigeminal nerve. In humans, hypoglossal peripheral nerve sheath tumours are rare, only few cases are described in literature; and the malignant forms are even exceptional. Fifty per cent of cases displayed both an intra- and extracrania component, and are referred as dumbbell-shaped tumours. To our knowledge this is the first case report an hypoglossal MPNST in a dog. In our case the tumour was dumbbell-shaped, with both intra-and extracranial components and associated with characteristic clinical signs of hypoglossal tumour. The malignant histological appearance of the lesion occurred without infiltrative growth
Immunohistochemical identification and image analysis quantification of oestrogen and progesterone receptors in canine and feline meningioma
No full textOestrogen and progesterone receptor expression has been detected in human meningioma; in canine and feline meningiomas, however, the identification of steroid receptors requires further investigation. Fourteen meningiomas obtained from nine dogs and five cats were examined immunohistochemically for oestrogen receptors (ORs) and progesterone receptors (PRs). The immunolabelling reaction was quantified by light microscopy and image analysis. ORs were expressed in low numbers in two feline meningiomas and in one canine meningioma. PRs were more numerous, with more extensive tissue labelling. Conventional linear regression analysis showed that OR expression was not significant as compared with PR expression. PR expression was lowest in meningiomas with a high proliferation index, as determined by Ki67 expression. Conventional linear regression analysis between PR and Ki67 concentration confirmed a significant indirect relationship. © 2002 Elsevier Science Ltd. All rights reserved
Modificazioni di attività enzimatiche nel siero di sangue, latte e tessuto mammario in pecore infettate sperimentalmente.
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