1,721,149 research outputs found
Conservative surgery for borderline ovarian tumors: a review
No full textGynecol Oncol. 2006 Jan;100(1):185-91. Epub 2005 Oct 10.
Conservative surgery for borderline ovarian tumors: a review.
Tinelli R, Tinelli A, Tinelli FG, Cicinelli E, Malvasi A.
Source
I Department of Obstetrics and Gynecology, University Medical School of Bari, Piazza Giulio Cesare, Bari, Italy. [email protected]
Abstract
OBJECTIVE:
Borderline tumor of the ovary is an epithelial tumor with a low rate of growth and a low potential to invade or metastasize. This review will outline the most recent information regarding the molecular pathogenesis, pathology, fertility and tumor recurrence rate after conservative management of young women with early-stage borderline ovarian tumors.
METHODS:
We performed a MEDLINE literature search of relevant clinical trials for the scope of this review that evaluated conservative treatment of borderline ovarian tumors for young women with low-stage disease who wish to preserve their fertility.
RESULTS:
Recently, investigators have begun to identify subsets of patients with a worse prognosis, such as patients with aneuploid tumors. A number of oncogenes are under investigation to determine their role in the pathogenesis of borderline ovarian tumors. Previous studies have suggested the safety of conservative surgery with unilateral salpingo-oophorectomy or cystectomy for patients with stage I borderline ovarian tumors. Laparoscopic treatment of adnexal masses has proved to be a safe and effective diagnostic and therapeutic tool in the hands of experienced laparoscopists. For women who are treated conservatively, follow-up is important. Surgery remains the most effective therapy for later stage lesions. Adjuvant therapy for advanced stage of borderline ovarian tumors remains controversial.
CONCLUSION:
Conservative management of borderline ovarian tumors is an appropriate therapeutic option for young women with early-stage lesions who wish to preserve their childbearing potential. Available data indicate that in these patients fertility, pregnancy outcome and survival remain excellent.
PMID: 16216320 [PubMed - indexed for MEDLINE
Is it time for midwives to do intrapartum ultrasound in the delivery ward?
Full text linkIn the last 40 years, intrapartum ultrasound (IU) has been a technique often used in the delivery ward. Many studies are reported in literature about it. According to literature, the IU improves especially the diagnosis of fetal head position (FHP) during the labor, in comparison with traditional digital vaginal examination (DVE). ISUOG practice guidelines highlighted high levels of evidence and grades of recommendation, in particular for the sonographic confirmation of FHP in the pelvis before OVD.
IU is currently used in the delivery room for FHP labor diagnosis with VE. The caput succedaneum in labor limits the DVE of FHP diagnosis because reduces the digital examinations of sutures and fontanels. Some authors demonstrate that angle of progression (AOP), head-perineal distance (HPD), and head-symphysis distance (HSD) are important to determine fetal head station during labor.
It is time for IU use by midwives together with obstetricians because it improves the traditional VE in the FHP diagnosis
Semeiotica Ostetrica.
No full text“Semeiotica” è un termine di derivazione greca e significa “segno”, che resta il cardine di qualsiasi processo diagnostico.
Alla Semeiotica Ostetrica, a differenza di quella Medica e Chirurgica, non è stato riservato uno spazio specifico nell’editoria, neanche in tempi moderni dove l’introduzione di nuove e diverse tecnologie ha ampliato il corredo sintomatologico e le possibilità diagnostiche in Ostetricia.
Anzi l’editoria degli ultimi decenni ha prodotto diversi testi su tecniche e metodologie specifiche, che pur meritando l’attenzione dovuta, restano una parte dell’intero processo diagnostico.
Nel processo diagnostico, oggi ancor più, appare importante coniugare i sintomi ed i segni classici della semeiotica ostetrica con i segni che più recentemente sono venuti affermandosi con l’utilizzo delle tecniche strumentali, come, ad esempio, l’ecografia e la cardiotocografia, per far riferimento a due metodologie comunemente impiegate nella pratica clinica quotidiana.
La ricerca dei segni va praticata sulla gestante nel feto, come processo unitario, evitando, quando possibile, di assegnare eccessiva importanza ad una tecnica in particolare nell’intero processo diagnostico.
Le metodologie diagnostiche restano comunque un mezzo da impiegare opportunamente nei casi richiesti e partecipano, con la semeiotica clinica, al fine comune che è rappresentato dal processo diagnostico.
Questo testo si propone l’obiettivo di sintetizzare ed unificare il processo diagnostico, rendendendolo accessibile allo studente, allo specializzando, alle ostetriche e a quanti specailisti riterranno di usufruirne, considerando la rapida e semplice fruibilità del testo reso ancor più accessibile dalla presenza di un gran numero di immagini.
Infatti la formula dell’illustrazione, che spesso manca nell’editoria italiana, si propone l’obiettivo di rendere il testo di facile consultazione e di attirare l’attenzione del lettore sul processo diagnostico, sperando che questo testo abbia l’attenzione che merita
The role of hysteroscopy with eye-directed biopsy in postmenopausal women with uterine bleeding and endometrial atrophy
No full textL'analgesia epidurale a lungo termine: un nuovo approccio terapeutico nella gestione della sindrome preeclamptica
No full text
Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma
No full textMolecular Human Reproduction
Volume 20, Issue 10, 2014, Pages 1009-1015
Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma (Article)
Di Tommaso, S.a,
Tinelli, A.b,
Malvasi, A.c,
Massari, S.a
a Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
b Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Department of Gynecology and Obstetrics, Vito Fazzi Hospital, Lecce, Italy
c Department of Obstetrics and Gynecology, Santa Maria Hospital, Bari, Italy
View references (36)
Abstract
Uterine leiomyoma (UL), the most common benign tumour found in females, is associated with many recurrent genetic aberrations, such as translocations, interstitial deletions and specific germline mutations. Among these, mutations affecting exon 2 of the mediator complex subunit 12 (MED12) gene are commonly detected in the majority of ULs. Mutational analysis of the MED12 gene, performed on 36 UL samples, revealed that 12 leiomyomas (33.4%) exhibited heterozygous missense mutations in codon 44 of exon 2 of the MED12 gene, four leiomyomas (11.1%) showedinternal in-frame deletions, and two leiomyomas (5.5%) exhibited deletions involving intron 1-exon 2 junction, which caused a predicted loss of the splice acceptor.Nomutations were detected in uterinemyometrium (UM) and pseudocapsule (PC) samples, including those from women with a MED12 mutation in UL. These data showed that the PC is a healthy tissue that surrounds the UL to maintain UM integrity. Analysis of insulin-like growth factor 2 (IGF-2) and collagen type IV alpha 2(COL4A2)mRNAexpression levels in the same set of ULs revealed that only those with MED12 missense mutations expressed significantly higher levels of IGF-2 mRNA. In contrast, MED12 gene status does not appear to affect mRNA expression levels of the COL4A2 gene. On the basis of this finding, we suggest that the MED12 status stratifies the ULs into two mutually exclusive pathways of leiomyoma genesis, one with IGF-2 overexpression and the other with no IGF-2 activation. The occurrence of IGF-2 overexpression could be therapeutically targeted for the non-surgical treatment of leiomyoma
Efficacy of a dermoxen lenitiva for pruritus genitalis in a randomized, double blind trial.
No full textBACKGROUND: Pruritus can be defined as an unpleasant cutaneous sensation associated with the immediate desire to scratch. In particular external intimate zone could be hit by pruritus genitalis because of several reasons (bacterial infection, fungal infection, stress, bad intimate behavior, synthetic intimate clothes).
AIM: The aim of the study was to compare the efficacy of Dermoxen® Lenitiva cream versus a methylprednisolone aceponate 0.1% based cream in treating pruritus of the external genitalia.
PATIENTS AND METHODS: Independent, randomized, double-blind, controlled trial in two University affiliated Italian Hospitals. 80 women, affected by aspecific pruritus genitalis with negative vaginal swab for bacterial or fungal infections or other pathogenic causes of itching, were selected and blindly treated by Dermoxen® Lenitiva cream or methylprednisolone aceponate 0.1% based cream. The main outcome measures were: the reduction of sensation of pruritus, evaluated by a visual analog scale (VAS) pain score, and improvement of intimate wellness sensation, and comfort during sexual intercourse, frequency and severity of adverse reactions.
RESULTS: Significant reduction of itching sensation was verified for each treatment.
CONCLUSIONS: Based on our results, DermoXen® Lenitiva vaginal cream showed efficacy so as methylprednisolone aceponate 0.1% based cream for itching treatment on external female genitalia and improved intimate comfort and comfort in sexual intercourse
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