4,574 research outputs found
The sinus endothelial cell architecture in the mouse lymph node. Structural peculiarities and close correlation with the fibroblastic reticular cells
No full textThe mast cell: an active participant or an innocent bystander?
No full textMast cells (MC) are phylogenetically old
cells which are distributed throughout the human
organism and, on the whole, occupy roughly the volume
of the spleen. MC have long been recognized as key
cells of type I hypersensitivity reactions. Several lines of
evidence, however, indicate that they not only express
critical effector functions in classic IgE-associated
allergic disorders, but also play important roles in host
defence against parasites, bacteria and perhaps even
viruses. Indeed, it is now clear that MC can contribute to
host defence in the context of either acquired or innate
immune responses through the release of a myriad of
pro-inflammatory and immunoregulatory molecules and
the expression of a wide spectrum of surface receptors
for cytokines and chemokines. Moreover, there is
growing evidence that MC exert distinct nonimmunological
functions, playing a relevant role in
tissue homeostasis, remodeling and fibrosis as well as in
the processes of tissue angiogenesis. In this review, we
provide a small insight into the biology of human MC
and their potential implications in clinical pathology
Diogenes of Apollonia: a pioneer in vascular anatomy
No full textDiogenes of Apollonia was a pre-Socratic philosopher who lived in the 5th century BC and provided the first systematic
and fairly truthful account of blood vessel architecture in man. This article presents Diogenes’ report and comments
on the most significant passages of his vascular description. It also discusses the magnitude of Diogenes’
contribution to shape early theories regarding blood vessel physiology. What emerges from this portrait is the figure
of an eclectic spirit, who remarkably influenced the development of leading concepts in vascular anatomy and
biology
Recombinant human alpha-2a interferon promotes an atypical process of mast cell secretion with ultrastructural features suggestive for piecemeal degranulation
No full textThe fine architecture of sinus endothelial cells in the mouse lymph node studied by the osmium-zinc iodice procedure
No full textApposition of enteric nerve fibers to plasma cells and immunoblasts in the mouse small bowel.
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Suggestive evidence for a Microanatomical Relationship betweeb Mast Cells and Nerve Fibres Containing Substance P, Calcitonin Gene Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in the rat Mesentery.
No full textGranule changes of human and murine endocrine cells in the gastrointestinal epithelia are characteristic of piecemeal degranulation
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