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Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers?
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Do Meta-Analyses of Association Studies of Endothelial Nitric Oxide Synthase (eNOS) Variants and Ischaemic Heart Disease Provide Conclusive Answers?
No full textNOX4: the good side of NADPH oxidase for cardiovascular system. Re: "Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling" Gray, et al.
No full textAngiotensin II type 1 and type 2 receptor interplay in hypertension: lesson from a human model of vascular hyporeactivity.
No full textMechanistic approach to the pathophysiology of target organ damage in hypertension from studies in a human model with characteristics opposite to hypertension: Bartter's and Gitelman's syndromes.
No full textIntroduction: Extensive studies using Bartter's/Gitelman's syndrome patients have provided insights into the angiotensin II (Ang II) signaling pathways involved in the regulation of vascular tone and cardiovascular-renal remodeling. The renin-angiotensin-aldosterone system is activated in these syndromes, however, patients do not develop hypertension and cardiovascular remodeling and clinically manifest conditions opposite to hypertension. The short- and the long-term signaling of Ang II remains an important matter of investigation to shed light on mechanisms responsible for the pathophysiology of hypertension and its long-term complications. The long-term signaling of Ang II is involved in the pathophysiology of cardiovascular-renal remodeling and inflammatory responses in which the balance between RhoA/Rho kinase pathway and NO system plays a crucial role. Methods and results: In this brief review, the results of our studies in Bartter's and Gitelman's syndromes are reported on these..
Hypomagnesaemia, cardiovascular-renal negative effects and Gitelman's syndrome: A paradox awaiting resolution.
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