1,721,089 research outputs found
Intestinal Anti-tissue Transglutaminase2 Autoantibodies: Pathogenic and Clinical Implications for Celiac Disease
No full textCeliac disease (CD) is a systemic disease that primarily affects the small intestine. The presence of anti-tissue transglutaminase 2 (anti-TG2) antibodies in the serum, as well as the presence of autoimmune phenomena, account for the inclusion of CD among autoimmune diseases. Anti-TG2 autoantibodies are produced at intestinal level, where they are deposited even before they appear in circulation. The pathogenic events that lead to their production are still not completely defined, but a central role seems to be played by gliadin-specific T cells. Interestingly, limited somatic mutations have been observed in VH and VL genes in TG2-specific plasma cells, another important aspect being the biased use of a heavy chain encoded by the VH5 gene. Conflicting data have been produced over the years on the effect of anti-TG2 antibodies on TG2 function. Although the presence of anti-TG2 antibodies in serum is considered a hallmark of CD and relevant from a clinical viewpoint, the role of these autoantibodies in the development of the celiac lesion remains to be defined. In the years, different technical approaches have been implemented to detect and measure intestinal CD-associated autoantibody production. Two aspects can make intestinal anti-TG2 antibodies relevant: from a clinical viewpoint: the first is their proposed ability in potential coeliac patients to predict the development of a full-blown enteropathy; the second is their possible role in revealing a condition of reactivity to gluten in patients with no circulating CD-associated autoantibodies. In fact, the detection of CD-specific autoantibodies production in the intestine, in the absence of serum positivity for the same antibodies, could be suggestive of a very early condition of gluten reactivity; alternatively, it could be not specific for CD and merely attributable to intestinal inflammation. In conclusion, the role of mucosal anti-TG2 antibodies in pathogenesis of CD is unknown. Their presence, the modalities of their production, their gluten dependence render them a unique model to study autoimmunity
An immunocytochemical study of intrapancreatic ganglia, nerve fibres and neuroglandular junctions in Brockmann bodies of the tompot blenny (Blennius gattoruggine), a marine teleost. Histochem. J, 32, 607-616, 2000
No full textParity-violating CFT and the gravitational chiral anomaly
Full text linkWe illustrate how the conformal Ward identities (CWI) and the gravitational chiral anomaly completely determine the structure of the (TTJ5) (graviton -graviton -chiral gauge current) correlator in momentum space. This analysis extends our previous results on the anomaly vertices (AVV) and (AAA), as well as the (TJJ) parity -odd conformal anomaly vertex in general CFTs. The (TTJ5) plays a fundamental role in the analysis of the conformal backreaction in early Universe cosmology, affecting the particle content and the evolution of the primordial plasma. Our approach is nonperturbative and not Lagrangian based, requiring the inclusion of a single anomaly pole in the solution of the anomaly constraint. The pole and its residue, along with the CWIs, determine the entire correlator in all of its sectors (longitudinal/transverse), all of which are proportional to the same anomaly coefficient. The method does not rely on a specific expression of the CP-odd anomalous current, which in free field theory can be represented either by a bilinear fermion current or by a gauge -dependent Chern-Simons current; it relies solely on the symmetry constraints. We compute the correlator perturbatively at one loop in free field theory and verify its exact agreement with the nonperturbative result. A comparison with the perturbative analysis confirms the presence of a sum rule satisfied by the correlator, similar to the parity -even (TJJ) and the chiral (AVV)
An immunocytochemical study of intrapancreatic ganglia, nerve fibres and neuroglandular junctions in Brockmann bodies of the tompot blenny (Blennius gattoruggine), a marine teleost. Histochem. J, 32, 607-616, 2000
No full textParity-odd 3-point functions from CFT in momentum space and the chiral anomaly
Full text linkWe illustrate how the Conformal Ward Identities (CWI) in momentum space for parity-odd correlators determine the structure of a chiral anomaly interaction, taking the example of the VVA (vector/vector/axial-vector) and AAA correlators in momentum space. Only the conservation and the anomalous WIs, together with the Bose symmetry, are imposed from the outset for the determination of the correlators. We use a longitudinal/transverse decomposition of tensor structures and form factors. The longitudinal (L) component is fixed by the anomaly content and the anomaly pole, while in the transverse (T) sector we define a new parameterization. We relate the latter both to the Rosenberg original representation of the VVA and to the longitudinal/transverse (L/T) one, first introduced in the analysis of g- 2 of the muon in the investigation of the diagram in the chiral limit of QCD. The correlators are completely identified by the conformal constraints whose solutions are fixed only by the anomaly coefficient, the residue of the anomaly pole. In both cases, our CFT result matches the one-loop perturbative expression, as expected. The CWIs for correlators of mixed chirality JLJJR generate solutions in agreement with the all-orders nonrenormalization theorems of perturbative QCD and in the chiral limit
An immunocytochemical study of intrapancreatic ganglia, nerve fibres and neuroglandular junctions in Brockmann bodies of the tompot blenny (Blennius gattoruggine), a marine teleost. Histochem. J, 32, 607-616, 2000
No full textTopological corrections and conformal backreaction in the Einstein Gauss–Bonnet/Weyl theories of gravity at D= 4
Full text linkWe investigate the gravitational backreaction, generated by coupling a general conformal sector to external, classical gravity, as described by a conformal anomaly effective action. We address the issues raised by the regularization of the topological Gauss–Bonnet and Weyl terms in these actions and the use of dimensional regularization (DR). We discuss both their local and nonlocal expressions, as possible IR and UV descriptions of conformal theories, below and above the conformal breaking scale. Our discussion overlaps with several recent studies of dilaton gravities – obtained via a certain singular limit of the Einstein–Gauss–Bonnet (EGB) theory – originally introduced as a way to bypass Lovelock’s theorem. We show that nonlocal, purely gravitational realizations of such EGB theories, quadratic in the dilaton field, beside their local quartic forms, are possible, by a finite renormalization of the Euler density. Such nonlocal versions, which are deprived of any scale, can be expanded, at least around flat space, in terms of the combination R□ - 1 times multiple variations of the anomaly functional, as pointed out in recent studies at d= 4. Similar conclusions can be drawn for the proposed nonlocal EGB theory. The expansion emerges from previous investigations of the anomalous conformal Ward identities that constrain such theories around the flat spacetime limit in momentum space
Exact correlators from conformal Ward identities in momentum space and the perturbative TJJ vertex
Full text linkWe present a general study of 3-point functions of conformal field theory in momentum space, following a reconstruction method for tensor correlators, based on the solution of the conformal Ward identities (CWI's), introduced in recent works by Bzowski, McFadden and Skenderis (BMS). We investigate and detail the structure of the CWI's, their non-perturbative solutions and the transition to momentum space, comparing them to perturbation theory by taking QED as an example. We then proceed with an analysis of the TJJ correlator, presenting independent and detailed re-derivations of the conformal equations in the reconstruction method of BMS, originally formulated using a minimal tensor basis in the transverse traceless sector. A careful comparison with a second basis introduced in previous studies shows that this correlator is affected by one anomaly pole in the graviton (T) line, induced by renormalization. The result shows that the origin of the anomaly, in this correlator, should be necessarily attributed to the exchange of a massless effective degree of freedom. Our results are then exemplified in massless QED at one-loop in d-dimensions, expressed in terms of perturbative master integrals. An independent analysis of the Fuchsian character of the solutions, which bypasses the 3K integrals, is also presented. We show that the combination of field theories at one-loop – with a specific field content of degenerate massless scalar and fermions – is sufficient to generate the complete non-perturbative solution, in agreement with a previous study in coordinate space. The result shows that free conformal field theories, in specific dimensions, arrested at one-loop, reproduce the general result for the TJJ. Analytical checks of this correspondence are presented in d=3,4 and 5 spacetime dimensions. This implies that the generalized 3K integrals of the BMS solution can be expressed in terms of the two single master integrals B0 and C0 of 2- and 3-point functions, with significant simplifications
Renormalization, conformal ward identities and the origin of a conformal anomaly pole
Full text linkWe investigate the emergence of a conformal anomaly pole in conformal field theories in the case of the TJJ correlator. We show how it comes to be generated in dimensional renormalization, using a basis of 13 form factors (the F-basis), where only one of them requires renormalization (F13), extending previous studies. We then combine recent results on the structure of the non-perturbative solutions of the conformal Ward identities (CWI's) for the TJJ in momentum space, expressed in terms of a minimal set of 4 form factors (A-basis), with the properties of the F-basis, and show how the singular behaviour of the corresponding form factors in both basis can be related. The result proves the centrality of such massless effective interactions induced by the anomaly, which have recently found realization in solid state, in the theory of topological insulators and of Weyl semimetals. This pattern is confirmed in massless abelian and nonabelian theories (QED and QCD) investigated at one-loop
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