1,721,026 research outputs found
Thyroid state-dependent effect of retinoic acid on thyroid hormone and retinoic acid receptors
No full textThyroid state-dependent effect of retinoic acid on thyroid hormone and retinoic acid receptors
A new case of Marine-Lenhart syndrome with a papillary thyroid carcinoma
No full textWe report the case of a patient with the coexistence of Graves’ disease and autonomously functioning thyroid nodules. Because of the suspicious ultrasound pattern, he was submitted to fine-needle aspiration of the hot nodule and cytology revealed a papillary thyroid cancer. After total thyroidectomy a papillary thyroid cancer was found
Thyroid hormone receptor (alpha) distribution in hamster and sheep brain:colocalization in gonadotropin-releasing hormone and other identified neurons
No full textA sensitive method for assaying thyroid stimulating immunoglobulins of Graves\' disease: use of the guanyl nucleotide-amplified thyroid adenylate cyclase assay
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Can the inibition of prostaglandin synthesis affect the adenylate cyclase response to thyroi stimulating antibodies?
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Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description
Full text linkThe molecular basis of thyroid hormone action
No full textDuring the 1950s and 60s, thyroid hormone was believed to control
metabolic
action by
uncoupling
oxidative
phosphorylation
(1, 2), despite obser-
vations that oxidative
phosphorylation
in muscle of
thyrotoxic
humans and animals was normally cou-
pled to generation of
high-energy
phosphate bonds
(3). In 1967 Tata
andWilliams-Ashman
(4) showed
that thyroid hormone caused prompt changes in
mRNA and protein synthesis, thereby shifting inte-
rest to a
nuclear
site of act ion for the hormone .
Following recogn ition of
nuclear
receptors for estro-
gen and
glucocorticoid
(5, 6), Schad low et al. and
Oppenheimer
et al. reported in 1972 the
presence
of
thyroid hormone binding
substances
, putative re-
ceptors, in pituitary, kidney, and liver (7,8) . Since that
time, the
concept
that thyroid hormone carries out its
action through nuclear receptors has dominated re-
search in this field, although there is evidence for entirely separate actions of thyroid hormone at the
cell membrane (9) and on
mitochondria
(10)
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