1,721,192 research outputs found
Monitoring anti-p53 antibodies in patients with laryngeal squamous cell carcinoma: response to surgical treatment
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Matrix metalloproteinases as biomarkers of disease : updates and new insights
No full textMatrix metalloproteinases (MMPs) play a pivotal role in remodeling the extracellular matrix (ECM) and are therefore of interest for new diagnostic tools for the clinical management of diseases involving ECM disruption. This setting ranges from the classical areas of MMP studies, such as vascular disease, cancer progression or bone disorders, to new emerging fields of application, such as neurodegenerative disease or sepsis. Increasing the knowledge about the role of MMPs in the pathogenesis of diseases where a clear diagnostic panel is still lacking could provide new insight and improve the identification and the clinical treatment of these human diseases. This review focuses on the latest descriptions of the clinical use of MMP as biomarkers in the diagnosis, prognosis and monitoring of different diseases, such as diabetes, cardiovascular diseases, cancer and metastasis, neurodegenerative disorders and sepsis
Platelet rich plasma therapy: inflammatory molecules involved in tissue healing
No full textInflammation represents a fundamental aspect of the healing process. Besides their primary role in hemostasis, platelets play an active role in the immunological and inflammatory aspect of tissue healing. Indeed , they can be directly involved in the inflammatory response by the production and release of several inflammatory mediators, including a variety of cytokines, such as TGF-beta, IL-1 beta, CD40L, and chemokines, such as CXCL7, CXCL4, CXCL4L1, CCl5, CXCL1, CXCL8, CXCL5, CXCL12, CCL2, CCL3. Platelet are not only a source of several chemokine involved in the inflammatory response and tissue healing, but they also express chemokine receptors, in particular CCR1 CCR3 CCR4 and CXCR4, thus being able to being able to regulate the inflammatory response associated to the healing process. However, this local inflammation must be taken under control, and platelets can prevent the excess of leukocytes recruitment by anti-inflammatory cytokines, such as TGF-beta. For this biological properties of platelets, platelet rich plasma therapy (PRP) is considered an innovative and promising approach that has been extended to many field of medicine, ranging from non-union defects, bone fractures, spinal fusion, bone implant and osteointegration, joint arthroplasty, to the treatment of several traumatic or degenerative pathologies of tendons, cartilage and ligaments
Could platelet rich plasma have effects on systemic circulating growth factors and cytokine release in orthopaedic applications?
No full textThe use of platelet rich plasma (PRP) has been proposed for tendon and ligament healing, because platelets release growth factors and cytokine/chemokines which aid the regeneration of the tissues. We applied PRP in tendinopathies of professional athletes and we measured, from the time of PRP application until 24 hours later, a series of cytokines and growth factors in serum obtained from peripheral blood in five male subjects for studying possible systemic effect of the therapy. We did not observe modifications of these parameters: interleukin 4, interleukin 6, interleukin 10, interleukin 1a, interleukin 1b, tumor necrosis factor a (TNFa) and interferon g. We observed modifications of vascular endothelial growth factor (VEGF), endothelial growth factor (EGF), and chemokine (C-C motif) ligand 2 (CCL2)
Osteoprotegerin, RANK and RANKL are not modified by acute exercise in elite rugby players
No full textAIM: The OPG-RANK-RANKL system is a new family of bone metabolism biomarkers belonging to the immune system. In this study, were evaluated these biomarkers in professional rugby players after a single-bout of training session.
METHODS: The study has been performed on 30 professional male rugby players during a training camp of the Italian National Team, in July, before the start of the competitive season. Blood drawings were performed before and after training in the same day. Levels of soluble OPG, RANKL RANK in serum specimens were measured by commercially available according to the manufacturers’ protocols.
RESULTS: All the bone markers examined displayed no significative changes after training session.
CONCLUSION: Short exercise is insufficient for modifying serum concentrations of these osteoimmunologic markers, as previously indicated for commonly used bone metabolism markers. Future studies will be conducted over an entire competition season in order to define a common profile of bone markers in rugby players
Chemokines and their receptors : roles in specific clinical conditions and measurement in the clinical laboratory
No full textConsiderable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. A large body of literature has been published describing various assays for the measurement of chemokines in biologic fluids and tissues. We review information available on the role of chemokines in selected human diseases and provide examples of clinical situations in which chemokine determination might be of practical value, and we describe the currently available assays for their measurement
Interplay of inflammation, immunity, and organ-specific adiposity with cardiovascular risk
Full text linkChemokines as pharmacological targets
No full textChemokines play a key role in immune processes by controlling leukocyte recruitment in physiological and pathological condition. This review discusses the regulation of the chemokine system, its role in human diseases, and its potential relevance as a new pharmacological target
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