30,323 research outputs found
Prefazione
No full textPrefazione dedicata allo stile comunicativo di Vincenzo De Luca e alle sua caratteristiche più o meno adeguate al nuovo ecosistema dei media digitali
Labelled Deduction
No full textPreface - D. Basin, M. D'Agostino, D. M. Gabbay, S. Matthews, L. Viganò.
Labelled Proof Systems for Intuitionistic Provability - V. Balat, D. Galmiche.
Normal Multimodal Logics with Interaction Axioms - M. Baldoni.
The SAT Problem of Signed CNF Formulas - B. Beckert, R. Hähnle, F. Manyà.
Discipline as Logic: Treating Labels as First Class Citizens - P. Blackburn.
Labelled Abduction (I) - K. Broda, D.M. Gabbay.
Labelled Tableaux for Propositional Linear Time Logic over Finite Frames - S. Cerrito, M. Cialdea Mayer.
Fibred Modal Tableaux - D.M. Gabbay, G. Governatori.
Labelled Deduction for the Guarded Fragment - M. Marx, S. Mikulás, S. Schlobach.
Semantics for Temporal Annotated Constraint Logic Programming - A. Raffaetà, T. Frühwirth.
The Logic of Reusable Propositional Output with the Fulfilment Constraint - L. van der Torre
Timing cue reliability
No full textDi Luca M, Knill D, Ernst MO. Timing cue reliability. In: Cue combination - Unifying Perceptual Theory. 2008
How long does it take to adjust a weight?
No full textErnst MO, Di Luca M, Knill D. How long does it take to adjust a weight? Journal of Vision. 2007;7(9):92
Testing the specificity of predictors of reading, spelling and maths: a new model of the association among learning skills based on competence, performance and acquisition.
No full textSummary of the Workshop Legal Information Retrieval meets Artificial Intelligence (LIRAI’23)
No full textPotential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic
No full textVitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide and displaying a broad spectrum of implications on cardiovascular and inflammatory disorders. Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-CoV-2 infection. We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic
Process intensification of the polishing step of a bioactive peptide through Multicolumn Countercurrent Solvent Gradient Purification
No full textPharmaceutical products, including peptides, must satisfy very strict purity specifications, because of quality and safety reasons. Therefore, the necessity to operate one or more purification steps to obtain high quality drugs is indisputable. Critical impurities chemically very similar to the target product are generated during the synthesis and are generally removed by means of preparative single-column chromatographic techniques (=batch methods) [1,2]. Batch methods struggle to separate completely the peptide of interest from other groups of impurities, because of their similarity and of high loading of sample processed in preparative conditions, which cause peaks overlapping [3]. The typical situation encountered in these cases is the so-called center-cut separation, where the target elutes as intermediate between two other groups of impurities less and more retained respectively. The direct consequence of this apparently insurmountable overlapping is a yield-purity trade-off, a limit intrinsic to batch chromatography according to which it is possible to obtain either high purity or high recovery of the peptide of interest, depending on whether the overlapping windows are collected or not [4]. This trade-off leads to drawbacks in the overall economy of the process. Multicolumn chromatographic processes, operating in continuous and countercurrent mode, can alleviate this limitation by performing internal recycling of the overlapping portions of the chromatogram [5]. The technique used in the frame of this research is twin-column Multicolumn Countercurrent Solvent Gradient Purification (MCSGP), which has been applied to the purification of an industrial crude of a bioactive decapeptide. It has been demonstrated that MCSGP leads to promising results, including a remarkable improvement in process performance (up to 6 times higher) from the point of view of recovery, productivity and solvent consumption, with respect to the corresponding batch run. The automation of the process on industrial scale would lead to great reproducibility which would reflect in improved consistency in product quality.
References
[1] De Luca, C.; Felletti, S.; Lievore, G.; Buratti, A.; Vogg, S.; Morbidelli, M.; Cavazzini, A.; Catani, M.; Macis, M.; Ricci, A.; Cabri, W. J Chromatogr A 2020, 1625, 1-7.
[2] De Luca, C.; Felletti, S.; Lievore, G.; Chenet, T.; Morbidelli, M.; Sponchioni, M.; Cavazzini, A.; Catani, M. Trends Analyt Chem 2020, 132, 1-8.
[3] Vogg, S.; Ulmer, N.; Souquet, J.; Broly, H.; Morbidelli, M. Biotechnol J 2019, 1800732, 1-8.
[4] Müller-Späth, T.; Ströhlein, G.; Lyngberg, O.; Maclean, D. Chem Today 2013, 31, 56-60.
[5] Steinebach, F.; Müller-Späth, T.; Morbidelli, M. Biotechnol J 2016, 11, 1126-1141
Luca Matranga e il suo tempo storico
No full textProfilo storico e biografico di Luca Matranga, primo autore in lingua arbëreshe. I dati archivistici recuperati permettono una ricostruzione accurata del profilo di questo papas di rito greco, che eseguì la traduzione nel dialetto albanese della "Piana dell'Arcivescovo" su richiesta del card. Ludovico II Torres, arcivescovo di Monreale
Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process for the intensification of the polishing step of a bioactive peptide mixture
No full textPharmaceutical products, including peptides, must satisfy very strict purity specifications, because
of quality and safety reasons. Therefore, the necessity to operate one or more purification steps to
obtain high quality drugs is indisputable. Critical impurities chemically very similar to the target
product are generated during the synthesis and are generally removed by means of preparative
single-column chromatographic techniques (=batch methods) [1,2]. Batch methods struggle to
separate completely the peptide of interest from other groups of impurities, because of their
similarity and of high loading of sample processed in preparative conditions, which cause peaks
overlapping [3]. The typical situation encountered in these cases is the so-called center-cut
separation, where the target elutes as intermediate between two other groups of impurities less and
more retained respectively. The direct consequence of this apparently insurmountable overlapping
is a yield-purity trade-off, a limit intrinsic to batch chromatography according to which it is possible
to obtain either high purity or high recovery of the peptide of interest, depending on whether the
overlapping windows are collected or not [4]. This trade-off leads to drawbacks in the overall
economy of the process. Multicolumn chromatographic processes, operating in continuous and
countercurrent mode, can alleviate this limitation by performing internal recycling of the
overlapping portions of the chromatogram [5]. The technique used in the frame of this research is
twin-column Multicolumn Countercurrent Solvent Gradient Purification (MCSGP), which has been
applied to the purification of an industrial crude of a bioactive decapeptide. It has been
demonstrated that MCSGP leads to promising results, including a remarkable improvement in
process performance (up to 6 times higher) from the point of view of recovery, productivity and
solvent consumption, with respect to the corresponding batch run. The automation of the process on
industrial scale would lead to great reproducibility which would reflect in improved consistency in
product quality.
[1] C. De Luca; S. Felletti; G. Lievore; A. Buratti; S. Vogg; M. Morbidelli; A. Cavazzini; M.
Catani; M. Macis; A. Ricci; W. Cabri, J Chromatogr A 2020, 1625, 1-7.
[2] C. De Luca; S. Felletti; G. Lievore; T. Chenet; M. Morbidelli; M. Sponchioni; A. Cavazzini; M.
Catani, Trends Analyt Chem 2020, 132, 1-8.
[3] S. Vogg; N. Ulmer; J. Souquet; H. Broly; M. Morbidelli, Biotechnol J 2019, 1800732, 1-8.
[4] T. Müller-Späth; G. Ströhlein; O. Lyngberg; D. Maclean, Chem Today 2013, 31, 56-60.
[5] F. Steinebach; T. Müller-Späth; M. Morbidelli, Biotechnol J 2016, 11, 1126-1141
- …
