12 research outputs found
Comparative evaluation of effect of laser on shear bond strength of ceramic bonded with two base metal alloys: An in-vitro study
No full textThe most common clinical failure in metal ceramic restoration is at the ceramo-metal interface. For the clinical longevity, metal-ceramic prostheses must have satisfactory bond strength between metal and ceramic.
Aim and Objective: The aim of this study is to evaluate the effect of Laser etching on shear bond strength between base metal alloys and ceramic.
Materials and Methods: A total of 60 specimens were made (Base 5 mm diameter and 1 mm thickness, step with 4 mm diameter and 4 mm in length). They were divided into three groups. Group A-control, Group B-sand blasting, and Group C-laser etching. The Surface morphology, surface roughness, and wettability of the specimens were observed under scanning electron microscope (SEM) Ceramic application was carried out layer by layer for an optimal height of 4 mm. The shear bond strength test was performed using a universal testing machine and the nature of the fracture was examined under SEM.
Results: The mean shear bond strength values for laser etched (Group C) Nickel-chromium (Ni-Cr) alloy bonded with ceramic was (49.12 ± 7.12 MPa) and ceramic bonded with Cobalt-chromium (Co-Cr) was (50.04 ± 4.27 MPa), sand blasted (Group B) Ni-Cr alloy bonded with ceramic was (26.00 ± 5.22 MPa), and ceramic bonded with Co-Cr was 24.54 ± 4.78 MPa. The SEM image after debonding showed 10% of adhesive failure and 70% cohesive failure and 20% of both adhesive and cohesive failure for Laser etching. However, there was no significant difference in the values of shear bond strength between the two base metal alloys in Group C.
Conclusion: The s hear bond strength between ceramic bonded with Ni-Cr alloys using the Laser etching as surface treatment was 49.12 ± 7.12 MPa and for Co-Cr alloys 50.04 ± 4.27 MPa. Laser surface treatment produces an excellent surface roughness and achieved good shear bond strength values and aid in achieving a better bond strength between metals and ceramic
Conformational structure of propranolol: A β-adrenergic blocking drug studied by NMR and PCILO methods
No full textConformational structure of propranolol: A β-adrenergic blocking drug studied by NMR and PCILO methods
No full textThe conformational structure of propranolol, a β-adrenergic blocking drug, has been investigated by pcilo calculations and 270-MHz proton nuclear magnetic resonance in D2O solution. The molecules coexist in at least two conformational states in solution with a low energy barrier. Both preferred conformations have extended structures which allow a three-point drug-receptor binding involving the aromatic moiety, the β-hydroxyl group, and -NH+2 groups of propranolol. The previously postulated "rigid" bicyclic structure does not exist to an appreciable extent in D2O solution
Role of <i>a</i>-substituent on the oxidation of <i>a</i>-amino acids by bromine in acid medium
No full text696-700The kinetics of oxidation of amino acids by bromine in aqueous, perchloric acid medium at 35°C has been studied. Based on the experimental results, a reaction scheme is proposed in which the active oxidants are bromine and HOBr. The electrophilic attack of bromine occurs at the carboxylate (- COO -) group. HOBr reacts with the amino acids through the a-hydrogen atom via hydride ion transfer or abstraction. The a-substituent plays a vital role in accelerating the rate limiting step
Towards Sustainable Abundance: The Advancements in Tamarind Production Technology
No full textTamarind, a tropical fruit-bearing tree, is essential for food, pharmaceutical, and industrial applications. Advancements in tamarind production technology are needed to ensure sustainable cultivation and efficient processing. This review focuses on innovative cultivation practices, breeding strategies, pest management, post-harvest practices, and value addition. It explores intercropping, agroforestry, and water-efficient irrigation systems to maximize land utilization and water resources. Integrated pest management strategies, such as biological control and organic pesticides, are proposed to reduce chemical dependency, minimize environmental impact, and maintain ecological balance. Post-harvest technology, including innovative harvesting, cleaning, storage, and processing techniques, is evaluated to maintain product quality and shelf life. The review also examines the economic viability and value addition opportunities within the tamarind industry, identifying potential product diversification and reducing the carbon footprint
Dielectric Behavior and A. C. Conductivity Studies on Cobalt Nanoferrites Synthesized Using Combustion Method
No full textToxicological evaluation of an antilithiatic polyherbal Siddha formulation-Sirupeellai Samoola Kudineer in experimental rats
No full text Sirupeellai samoola kudineer (SK), a polyherbal decoction, has been used in Siddha system of medicine for the management of Urolithiasis. Since, there exists no documentation of preclinical toxicological evaluation of SK earlier, in the present study, acute and subacute toxicity of SK was assessed in Sprague Dawley rats as per OECD guideline 423 and 407, respectively. In the acute toxicity study, SK did not produce any toxic signs at a dose level of 50 ml/kg b.wt/p.o. Three doses of SK (4.5, 9.0, 18.0 ml/kg b.wt) were administered and observed for various behavioral, physiological, biochemical, and haematological changes for 28 days in the subacute toxicity study. Low and mid dose of SK (4.5 and 9.0 ml/kg b.wt) did not exhibit any significant physiological and haematological alterations. Whereas, high dose (18.0 ml/kg bw) treatment exhibited significant changes in creatinine, gamma glutamyl transferase (GGT) and acid phosphatase (ACP) levels in serum. Further, histopathological examinations of brain, heart, liver, kidney and sex organs revealed normal architecture signifying no morphological changes upto a dose of 9.0 ml/kg. However, 18.0 ml/kg of SK administration showed few histopathological changes as compared to the control. Based on these results, it can be concluded that Sirupeellai samoola kudineer is safe and non-toxic upto 9.0 ml/kg for 28 days in experimental rats. </jats:p
A study to assess the burden among caregivers of schizophrenic clients
No full textSchizophrenia characterized by a breakdown in thinking and poor emotional responses. Schizophrenia causes significant social and work problems. The aim of this study is to find out the association of burden among caregivers with their selected demographical variables and with Persons with schizophrenia demographical variables. A cross sectional descriptive research design was employed by using non-probability convenient sampling technique. Data was collected by using a BASS standardized interview questionnaire from 210 caregivers of schizophrenic clients on a psychiatric ward and outpatient department, SVRRGGH, Tirupati. Majority (37.6%) had mild burden followed by 31.9% had moderate burden, and 30.5% had severe burden. There is a significant relationship between knowledge with caregivers variables like age, marital status, type of family at the level of p<0.05 and occupation, residence, monthly income and relationship to patient at the levels of p<0.01
In silico docking studies of α‑amylase inhibitors from the anti‑diabetic plant Leucas ciliata Benth. and an endophyte, Streptomyces longisporofavus
No full textIn this investigation, potential inhibitors of α-amylase, one of the key regulatory enzymes in diabetes were characterized from the methanolic extract of Leucas ciliata Benth. (Lamiaceae), a traditional medicinal plant of the Western Ghats, southern India and the ethyl acetate extract of Streptomyces longisporoflavus (JX965948), an endophytic actinomycete isolated from the stem fragments of L. ciliata, by Gas Chromatography and Mass Spectroscopy (GC–MS) technique followed by molecular docking studies. Forty-four compounds were detected in the solvent extracts of the host plant and the endophyte, respectively. These compounds were selected as ligands for the receptor α-amylase in the molecular docking studies using PyRx software (0.8 V) for the inhibition of α-amylase activity. The ligands were ranked based on the binding energies ranging between − 3.1 and − 10.1 kcal/mol. Three ligands from the host plant extract, viz., Topotecan (PNo_7), Cathine (PNo_17) and 2,5-dimethoxy-4-(methylsulfonyl)amphetamine (PNo_18), depicted good binding energies of − 5.2 to − 7.8, respectively, whereas seven compounds from the endophyte extract showed binding energies in the range of − 4.7 to − 10.1, respectively. The standard α-amylase inhibitor Acarbose™ depicted binding energy of − 9.2 kcal/mol. All ligands were subjected to lead-likeliness property using Lipinski’s rule of five. On the basis of the hydrogen bonding interactions with the receptor, and chemoinformatics analysis for drug-likeliness, one ligand, Topotecan (PNo_7) from the host plant was identified as the potential α-amylase inhibitor. This is the first attempt to identify alkaloid and flavonoid compounds as the α-amylase inhibitors from the host plant and its endophyte simultaneously. The molecular docking analyses presented in this study could lead to the development of potent α-amylase inhibitors helpful in the treatment of diabetes
