1,572 research outputs found
Appunti sulle "Lettere" guittoniane (con una nota su Finfo)
No full textThe essay outlines both the latest philological and critical acquisition of knowledge concerning what is believed to be the set of Letters of Guittone d’Arezzo. It also examines the hypothesis of dealing with texts according to a critical perspective that points to a historical and sociological reconstruction of the Guittonian work. Two notes on Finfo del Buono conclude the essay: one concerning Finfo’s biography, the other concerning the interpretation of the second stanza of Vostr’amoroso dire
Modulation of gene expression in the rat brain by acetyl-l-carnitine
No full textAcetyl-l-carnitine (ALC) has been shown to exhibit many neuromodulatory and neurotrophic actions on neuron activity. It is a molecule of considerable interest for its clinical application in various disorders, including Alzheimer’s disease and painful neuropathies. Studies reported that ALC treatment produces long lasting effects in learning processes, suggesting an involvement of gene modulation. The ALC action on gene expression is recently revealed by suppression subtractive hybridization method studies for the generation of subtracted cDNA libraries and the subsequent identification of differentially expressed transcripts after ALC treatment of rats (Traina et al., Mol. Brain Res, 132, 57-63, 2004). The technique generates an equalized representation of differentially expressed genes and it is based on the construction of forward and reverse cDNA libraries that allow the identification of the genes that are regulated after ALC treatment. We have singled out a multifocal control of ALC: i) an up-regulation of both 14, 3, 3 protein, gamma subunit, and of heat shock protein 72, contributing to establish a cytoprotective state in inflammation, neurodegenerative disorders, and aging; ii) a down-regulation of ATP-synthase lipid-binding protein, and positively increases lysosomal H+ATPase gene expression. The effects have implications in ceroid lipofuscinosis pathology. In addition, ALC treatment up-regulates VDAC1 gene expression that might exert an antiapoptotic role, and seems to have a pivotal role on synaptic plasticity (Traina et al., Neurochem. Int., in press). Finally, ALC down-regulates ferritin-H expression, and myelin basic protein, and up-regulates kinesin1 light chain, responsible for many of the microtubule-dependent transport pathways for fast anterograde axonal transport. It is associated with amyloid precursor proteins. Our data on gene expression, therefore, might be of relevant importance for a human treatment of many clinical malignancies
Gene expression is modulated by acetyl-l-carnitine treatment in the rat brain
No full textAcetyl-l-carnitine (ALC) has been shown to exhibit many neuromodulatory and neurotrophic actions on neuron activity. ALC is also a potential source of acetyl groups for the synthesis of acetylcholine in the mammalian brain. Several investigations reported that ALC treatment produces long lasting effects in learning processes, suggesting an involvement of gene modulation. The ALC action on gene expression is recently revealed by suppression subtractive hybridisation method (SSH) studies. SSH method was applied for the generation of subtracted cDNA libraries and the subsequent identification of differentially expressed transcripts after treatment of rats with ALC. The technique generates an equalized representation of differentially expressed genes irrespective of their relative abundance and it is based on the construction of forward and reverse cDNA libraries that allow the identification of the genes that are regulated after ALC treatment. In recent experiments we have singled out an up-modulation of either 14,3,3 protein or of heat shock protein, contributing to establish a cytoprotective state in inflammation, neurodegenerative disorders, and aging. In addition, we showed that treatment produces a down-regulation on ATP-synthase lipid-binding protein gene expression. This effect has implications in ceroid lipofuscinosis pathology (Traina et al., Mol. Brain Res, 132, 57-63, 2004). More recently, we have observed that ALC treatment positively increases lisosomial H+-ATPase, also involved in lipofuscinosis, and VDAC1 gene expression. VDAC might exert an antiapoptotic role, and, seems to have a pivotal role on synaptic plasticity. In addition, ALC down-regulates ferritin-H expression. This gene seems involved in cell growth and differentiation. Our data on gene expression, therefore, might be of relevant importance for a human treatment of many clinical malignancies
S.Giovanni di Efeso nel V sec. a.C. Note critiche
No full texta cura di G.Cavallo, G. De Gregorio, M. Maniaci, Spolet
Traina, Alfonso (1925-2019)
No full textProfilo biobiliografico di Alfonso Traina, uno dei maggiori latinisti del XX secolo, con discussione dei principali temi di ricerca e degli apporti alla comunità scientifica provenienti dai suoi lavori, sviluppati lungo un arco temporale di quasi un settantennio e dedicati a ogni fase della lingua e letteratura latina, dalle origini al neolatino
The Parthians
No full textStudy on the Parthian period in the ancient region of Margiana (Turkmenistan
Ancora su un (probabile) risponditore di ‘A ciascun alma presa e gentil core’: Terino da Castelfiorentino
No full textQuesto lavoro ha tre obiettivi fondamentali: fornire un’interpretazione generale dei testi di terino da Castelfiorentino; proporre qualche osservazione metodologica sulla questione attributiva di Naturalmente chere ogni amadore e, nella parte più innovativa, ragionare su documenti d’archivio sia noti che inediti sulla base dei quali i critici passati hanno costruito varie ipotesi identificative per il rimatore.this contribution has three main purposes: to provide a general interpretation of terino da Castelfiorentino’s verses; to propose some methodological observations about the issue of Naturalmente chere ogni amadore authorship, and, in the most innovative part, to reason on both known and unpublished archival documents. Based on these, previous critics proposed various hypotheses to identify the poet
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