263 research outputs found
Torcia al plasma
No full textIl presente trovato concerne una torcia al plasma ad arco trasferito per il taglio dei materiali metallici con elevate caratteristiche di durata degli elementi operativi e con innovazioni nella gestione del gas secondario
Differential inflammatory response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae.
No full textNGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation
No full textThe sIgG(+) lymphoblastoid B cell line CESS spontaneously produces a high amount of NGF and expresses both high affinity (p140(Trk-A)) and low affinity (p75(NTR)) NGF receptors. Blocking NGF signals with neutralizing antibodies or specific Trk-A inhibitors induces a rapid phosphorylation of antiapoptotic Bcl-2 protein, followed by caspase activation, and apoptotic death of CESS cells. Bcl-2 phosphorylation in several sites within a approximate to 60 aa "loop" domain of protein is known to regulate its antiapoptotic function. Accordingly, CESS cells expressing the loop deletional mutant cDNA constructs Bcl-2 Delta 40-91 were completely resistant to apoptosis induced by NGF withdrawal, indicating that Bcl-2 phosphorylation is a critical event. NGF withdrawal induces p38 MAPK, but not JNK, activation in CESS cells, and SB203580, a specific inhibitor of p38 MAPK, is able to prevent both Bcl-2 phosphorylation and apoptosis, indicating that p38 MAPK is the enzyme responsible for these events. (C) 2000 Academic Press
Nerve growth factor (NGF) prevents apoptosis of memory B cells: its role in maintaining a correct Bcl-2 structure and function.
No full textNerve growth factor inhibits apoptosis via inactivation of p38MAPK, prevention of Bcl-2 phosphorylation and cytochrome c release.
No full textSpontaneous in utero second-trimester resolution of isolated mild fetal megalourethra
No full textCongenital megalourethra is a rare disorder characterized by the congenital deficiency of the mesodermal tissues of the phallus (corpus spongiosum and corpus cavernosum), leading to enlargement of the penile urethra. We report a case of spontaneous in utero resolution of isolated congenital megalourethra diagnosed in the second trimester. Transabdominal 2- and 3-dimensional sonography showed fusiform cystic dilatation of the penis without any sign of hydronephrosis. The male neonate was delivered at term, and at clinical examination, the penis appeared normal in size and form
Nerve growth factor inhibits apoptosis via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation and cytochrome c release
No full textTunneled central venous catheter exchange : Techniques to improve prevention of air embolism
No full textMalfunctioning tunneled hemodialysis central venous catheters (CVCs), because of thrombotic or infectious complications, are frequently exchanged. During the CVC exchanging procedure, there are several possible technical complications, as in first insertion, including air embolism. Prevention remains the key to the management of air embolism. Herein, we emphasize the technical tricks capable of reducing the risk of air embolism in long-term CVC exchange. In particular, adoption of a 5 to 10 degrees Trendelenburg position, direct puncture of the previous CVC venous lumen for guide-wire insertion, as opposed to guide-wire introduction after cutting the CVC, a light manual compression of the internal jugular vein venotomy site after catheter removal. The Valsalva maneuvre in collaborating patients, valved introducers, and correction of hypovolemia are also useful precautions. Principles of air embolism diagnosis and treatment are also outlined in the article
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