1,145 research outputs found
[Letter from T. N. Carswell to Captain M. D. Whiteside - August 31, 1944]
No full textA letter written to Captain M. D. Whiteside, Air Surgeon's Office, War Department, Pentagon Building, Washington, D. C., from T. N. Carswell, Abilene Chamber of Commerce, Abilene, Texas, dated August 31, 1944. Carswell advises Whiteside that Mr. Collier will carry on the effort to secure the hospital location for Abilene
The Mathematical papers of Isaac Newton, ed. by D. T. Whiteside & M. A. Hoskin, vol. II, 1667-1670
No full textItard Jean. The Mathematical papers of Isaac Newton, ed. by D. T. Whiteside & M. A. Hoskin, vol. II, 1667-1670. In: Revue d'histoire des sciences et de leurs applications, tome 21, n°2, 1968. pp. 188-190
The Mathematical papers of Isaac Newton, ed. by D. T. Whiteside & M. A. Hoskin, vol. II, 1667-1670
No full textItard Jean. The Mathematical papers of Isaac Newton, ed. by D. T. Whiteside & M. A. Hoskin, vol. II, 1667-1670. In: Revue d'histoire des sciences et de leurs applications, tome 21, n°2, 1968. pp. 188-190
The Mathematical Papers of sir Isaac Newton, vol IV : 1674-1684, ed. by D. T. Whiteside with M. A. Hoskin and A. Prag
No full textItard Jean. The Mathematical Papers of sir Isaac Newton, vol IV : 1674-1684, ed. by D. T. Whiteside with M. A. Hoskin and A. Prag. In: Revue d'histoire des sciences, tome 26, n°3, 1973. pp. 269-271
The Mathematical Papers of Isaac Newton, ed. by D. T. Whiteside, M. A. Hoskin and A. Prag, vol. III, 1670-167
No full textItard Jean. The Mathematical Papers of Isaac Newton, ed. by D. T. Whiteside, M. A. Hoskin and A. Prag, vol. III, 1670-167. In: Revue d'histoire des sciences, tome 24, n°3, 1971. pp. 270-272
The Mathematical Papers of Isaac Newton, ed. by D. T. Whiteside, M. A. Hoskin and A. Prag, vol. V : 1683-1684
No full textItard Jean. The Mathematical Papers of Isaac Newton, ed. by D. T. Whiteside, M. A. Hoskin and A. Prag, vol. V : 1683-1684. In: Revue d'histoire des sciences, tome 27, n°1, 1974. pp. 92-94
The Mathematical Papers of Isaac Newton, ed. by D. T. Whiteside, M. A. Hoskin and A. Prag, vol. III, 1670-167
No full textItard Jean. The Mathematical Papers of Isaac Newton, ed. by D. T. Whiteside, M. A. Hoskin and A. Prag, vol. III, 1670-167. In: Revue d'histoire des sciences, tome 24, n°3, 1971. pp. 270-272
Immunologic effector cells in head and neck cancer.
No full textFreshly isolated tumor-infiltrating lymphocytes (TIL) and lymph node lymphocytes (LNL) in patients with head and neck cancer (HNC) often have low or undetectable functional responses. Because impaired ability of these cells to produce cytokines could be responsible for their functional incompetence, spontaneous and in vitro-induced production of interleukin-2 (IL2), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interferon gamma (IFN-gamma) by TIL, LNL from tumor-free as well as tumor-involved lymph nodes (LN), and peripheral blood lymphocytes (PBL) were measured. Although TIL or PBL of patients with HNC produced IL-1 beta and TNF-alpha spontaneously or after in vitro activation, LNL did not produce measurable levels of these cytokines. LNL also produced lower levels of IFN-gamma than PBL. In situ hybridization for cytokine mRNA performed with tumor tissues, and LN of patients with HNC showed that TIL as well as LNL localized in the immediate proximity of the tumor were activated, as evidenced by the expression of mRNA for IL2, IFN-gamma, IL-1 beta, TNF-alpha, and both alpha- and beta-chains of the IL2 receptor. In addition, many LNL located next to the tumor expressed mRNA for transforming growth factor-beta (TGF-beta). In contrast, LNL not adjacent to the tumor in involved LN, as well as those in tumor-uninvolved LN, did not express mRNA for cytokines or IL2 receptor.(ABSTRACT TRUNCATED AT 250 WORDS
Dendritic Cell-Based Melanoma Vaccines
No full textManfred Zierhut (Ed.), Swets and Zeitlinger, Leiden, The Netherlands
Rapid Il-2-induced adherence of human natural killer cells. Expression of mRNA for cytokines and IL-2 receptors in adherent NK cells.
No full textNatural killer (NK) cells selected by IL-2-induced rapid adherence to plastic and called A-NK cells represent a phenotypically and functionally distinct subset of mature peripheral blood NK cells. To further characterize this subset of NK cells functionally, their potential to express mRNA for the IL-2R and various cytokines after IL-2 activation was examined. Highly purified normal human peripheral blood resting NK (R-NK) cells were obtained by negative immunoselection using OKT3 mAb and magnetic beads coated with goat anti-mouse Ig. By two-color flow cytometry, > 90% of these R-NK cells were either CD3-CD56+CD16+ or - or CD3-CD56-CD16+. R-NK cells were activated in the presence of 6000 IU/ml (22 nM) of IL-2 for different periods of time. After 1, 3, 5, or 24 h, plastic-adherent (A) and nonadherent (NA) NK cells were separated and compared for the expression of the IL-2R or cytokine mRNA by in situ hybridization, using 35[S]-cDNA probes. Only low proportions of R-NK cells expressed genes for IL-2Rp55 (16%) or cytokines IL-2 (20%), IFN-gamma (18%), TNF-alpha (16%), and TGF-beta (7%). Thus, the genes for the IL-2Rp55 and these cytokines were not constitutively expressed by most human R-NK cells, and there was no indication that the NK cells used in these experiments were activated in vivo or during the purification procedure. However, larger proportions of R-NK cells showed expression of mRNA for IL-1-beta (35%) and IL-6 (40%), which indicates that genes for these cytokines may be constitutively expressed in a substantial proportion of normal human circulating NK cells. When R-NK cells were incubated in the presence of 22 nM of IL-2 for 1 to 24 h and separated into A-NK cells and NA-NK cells, a large proportion of A-NK cells became positive for IL-2R and cytokine gene expression. In contrast, the proportion of mRNA-positive NA-NK cells was similar or lower than that observed for R-NK cells, with the exception of an increase in TGF-beta.(ABSTRACT TRUNCATED AT 400 WORDS
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