210 research outputs found
Chronik für Ohrdruff : Ein Zeit- und Sitten-Gemählde zur Feyer der nachstehenden Jahrhunderte und zur Belehrung der Nachkommen desgleichen ; Ein Geschenk für Ohrdruffs Töchter / von Johann Friedrich Krügelstein M. D. Physikus und Bürgermeister daselbst
No full textAutopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Erfurt, gedruckt bey Johan Philipp Christian Reuß. Zu haben bey dem Buchbinder Meister Stadermann in Ohrdruff
Fotografie KM-F.30
No full textFotografie des Josef M., "Raubmörder und Dieb", rückseitig "Photographisch artistische Anstalt Harald Stadermann
Results of surgical treatment for renovascular hypertension in children : 30 year single centre experience
No full textBackground. We retrospectively reviewed the medical records of all patients who underwent surgery as part of the treatment of renovascular hypertension (RVH) at our centre between 1979 and 2008.Patients. Thirty-seven children (65% male) with a median age of 7.6 (0.4-17.9) years were identified with a median systolic blood pressure (SBP) of 140 (105-300) mm Hg prior to surgery. Bilateral renal artery stenosis and intra-renal disease were present in 19 (51%) patients, mid-aortic syndrome in 15 (40%), involvement of visceral arteries in eight out of 35 (23%) and coexisting cerebral disease in eight out of 30 (26%) investigated patients.Results. Surgical procedures (n = 53) included (i) nephrectomy (18, of which two unplanned and two secondary due to technical failure), (ii) renovascular surgery on the renal arteries (28, of which 18 had autologous surgery and 10 synthetic grafts inserted for revascularisation) and (iii) aortic reconstruction with (6) and without (1) a synthetic graft. Post-operative complications were haemorrhage (5), septicaemia (5) and chylous ascites (1). There were no perioperative deaths; two children died during follow-up. The SBP post-surgery improved to a median value of 116 (range 90-160) mm Hg. Twelve months after surgery, 16 (43%) children had normal blood pressure without treatment, 15 (41%) normal or improved on one to four antihypertensive drugs and four (11%) unchanged; no data were available for two (5%) children.Conclusion. Surgery effectively treated the hypertension of 90% of our children, when performed in conjunction with medical therapy and interventional radiology. In spite of aggressive surgical treatment, RVH is sometimes a progressive disease
ReadXplorer - Visualization and Analysis of Mapped Sequences
No full textHilker R, Stadermann KB, Doppmeier D, et al. ReadXplorer - Visualization and Analysis of Mapped Sequences. Bioinformatics. 2014;30(16):2247-2254.MOTIVATION: Fast algorithms and well-arranged visualizations are required for the comprehensive analysis of the ever-growing size of genomic and transcriptomic next-generation sequencing data.
RESULTS: ReadXplorer is a software offering straightforward visualization and extensive analysis functions for genomic and transcriptomic DNA sequences mapped on a reference. A unique specialty of ReadXplorer is the quality classification of the read mappings. It is incorporated in all analysis functions and displayed in ReadXplorer's various synchronized data viewers for (i) the reference sequence, its base coverage as (ii) normalizable plot and (iii) histogram, (iv) read alignments and (v) read pairs. ReadXplorer's analysis capability covers RNA secondary structure prediction, single nucleotide polymorphism and deletion-insertion polymorphism detection, genomic feature and general coverage analysis. Especially for RNA-Seq data, it offers differential gene expression analysis, transcription start site and operon detection as well as RPKM value and read count calculations. Furthermore, ReadXplorer can combine or superimpose coverage of different datasets.
AVAILABILITY AND IMPLEMENTATION: ReadXplorer is available as open-source software at http://www.readxplorer.org along with a detailed manual.
CONTACT: [email protected]
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
The Author 2014. Published by Oxford University Press
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Investigation into Igneous Lithologies and Impact Processes in the Earth-Moon System
No full textIn this dissertation, I work to characterize igneous lithologies and understand how impact processes produce and alter material on rocky surfaces. I investigate these topics to answer long-standing questions about volcanism and impact cratering on the Moon. I identify two new basalt types from the Moon: a potentially young, Th-enriched mare basalt from the previously unsampled region of the Moon, western Oceanus Procellarum; and evidence for an Mg-rich, spinel-bearing basalt that may represent extrusive Mg-suite magmatism. For the mare basalt, I conducted petrologic experiments that showed the sample is representative of the lava flow it originated from and showed that the sample likely underwent a late-stage, enigmatic processes known as silicate liquid immiscibility. We provide hypotheses for the provenance of this sample. The Mg-rich samples occur as clasts, some of which we determine to be of impact melt origin. However, a subset of the clasts have very similar texture and mineral chemistry. We propose that this subset of clasts may be volcanic in origin, and call for further investigations of these samples. The samples in both of these studies were impact-modified. The former came from a soil sample, likely delivered to the Apollo 12 site by a young impact event. The latter involves clasts embedded in an impact melt breccia. For the final portion of my dissertation, I characterize a polymict, impact melt-bearing rock (known as suevite) from Ries Crater in Germany to constrain the pressures and temperatures involved informing such a rock and constrain formation mechanisms. I identify zircon grains that have experienced a variety of pressure and temperature conditions, ranging from unshocked and unheated, to highly shocked, to heated, to both highly shocked and heated. The diversity of grains identified in this single sample provide insights into the formation of the suevite as a lateral flow. This terrestrial study is crucial to better understanding the impact cratering process, which produces knowledge that can be extended to more heavily impacted surfaces like the Moon’s. All of these studies, of impact altered rocks, of new igneous lithologies, and of impact cratering effects on target material, combine to set the stage for upcoming sample return missions from the Moon. The proposed Artemis missions, return humans to the Moon, will land near the lunar south pole, a heavily cratered and ancient surface. This dissertation lays some of the groundwork on how to best characterize the impact modified samples likely to be returned from the Moon. I have structured the document to begin with an introduction to lunar science and lunar rocks, followed by a description of the methods I used to conduct my research. Next, I will discuss the Th-enriched mare basalt found at Apollo 12, the Apollo 16 samples that may represent extrusive Mg-suite magmatism, and an investigation of pressures and temperatures recorded zircons in a sample from Ries Crater, Germany. Finally, I will close with a brief summary of my findings, their implications, and potential directions for future research
Why and how teachers use nature of science in teaching quantum physics:Research on the use of an ecological teaching intervention in upper secondary schools
No full textStudents at upper secondary and college level in many countries are introduced to quantum physics (QP) in a mostly math-less course. Research shows that addressing epistemological and philosophical aspects would be beneficial for novice students’ conceptual understanding. However, physics teachers seldom address these Nature of Science (NOS) aspects in their lessons. We take the view that teachers only implement these aspects if this serves their goals. This study explores whether experienced Dutch high school teachers, who are not trained for NOS teaching, address NOS in their QP lessons when provided with NOS-infused teaching resources. We based our framework on literature about pedagogic content knowledge and on the principles of the practicality of educational innovations. Teacher interviews (N=10) supported by classroom observations provided insights into how and why teachers use specific elements from the resources. Our research reveals teachers’ perspectives on teaching QP in secondary schools and why they think NOS aspects can be helpful to reach their teaching goals. Our findings support the view that conceptual QP is valuable for all students because an informed NOS view is vital for everybody in today’s society. Additionally, we expect that an ecological intervention that supports teachers and at the same time recognizes their professionality and environment has potential implications for other fields of science education and could have a significant positive impact in classrooms
The core of secondary level quantum education: a multi-stakeholder perspective
No full textQuantum physics (QP) education at the secondary school level is still in its infancy. Not only is there ongoing discussion about how to teach this subject, but there is also a lack of coherence in the selection of concepts to be taught, both across countries and over time. To contribute to this discussion, we investigated the perspectives of N=39 high school teachers, university-level physics educators, and physics education researchers regarding the essential concepts in QP and the corresponding illustrations that should be introduced at the secondary school level. We examined the prominence of different key concepts and illustrations, as well as the level of consensus among the various professional groups. Our analysis revealed that certain key concepts are universally valued across all professional groups, while others are specific to particular groups. Additionally, we explored the relationships between these key concepts and their corresponding illustrations. Overall, our study offers valuable insights into the perspectives of different stakeholders, emphasizing the essential concepts and visualizations that should be considered when designing and implementing the teaching of QP at the secondary school level.</p
A method to correct defocused element distribution maps in electron probe microanalysis
No full textElement distribution maps obtained on electron microprobes via the beam scan method with wavelength-dispersive spectrometers reveal a defocusing effect if they are taken at sufficiently small magnification. This effect, which occurs where the Bragg condition of the spectrometer is not adequately met, can be avoided or corrected by various methods. A method is presented here to correct defocused element distribution maps with the help of corresponding maps obtained on homogeneous standards
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