1,315 research outputs found
AUTOIMMUNE HEPATITIS: HALF A CENTURY WITH A CHILDHOOD DISEASE
No full textAutoimmune hepatitis is a severe inflammatory liver disease typical of childhood. This update article illustrate the main novelties on this disorde
Il "fegato grasso" del bambino: malattia o disturbo cosmetico ?
No full textFatty liver disease (FLD) is the term used to describe a spectrum of liver disorders characterized by macrovesicular steatosis. In adults and adolescents alcohol consumption in amounts considered to be harmful to the liver must be excluded. Because of the likehood of having FLD is directly proportional to body mass index, given the increasing prevalence of obesity, non-alcoholic FLD (NAFLD) is an important public health problem. There are two recognized histologic pattern of NAFLD: fatty liver alone and steatohepatitis (NASH). The latter represents a shift from simple steatosis to an inflammatory component. NASH is described by grading that indicates the activity of the inflammatory lesion and by staging that reflects the progressive degree of fibrosis. The presence of fat in the liver can be suggested by various imaging modalities, however no current non invasive methods can distinguish NASH from NAFLD. Liver biopsy remains the gold standard for staging and grading. The presence, degree and pattern of aminotransferase elevation are non specific and do not distinguish between fatty liver alone and NASH. Prevalence of FLD in unselected children is about 10% and it increases with age; in selected population such as obese children it reaches about 50% al cases. Obesity and insulin resistance are key factors in exacerbating hepatic inflammation and fibrogenesis. There is no effective treatment of NAFLD, but there are several approach to this problem including weight reduction by diet and exercise, pharmacologic treatment of insulin resistance and use of drugs such as antioxidant (α-tocopherol) or insulin sensitizer such as metformin
Le epatiti autoimmuni sieronegative in età pediatrica
No full textDiagnosis of autoimmune hepatitis lies in few biochemical and histological features. None of them is essential and absence of conventional autoantibodies(ANA, SMA, LKM) determines the so called seronegative autoimmune hepatitis. This entity is accepted and
well defined in adult patients while descriptions in childhood are rare. Here we propose a first analysis of existing data, matched with our personal experience,and we attempt to draw an initial description of this group of disorders
Autoimmune hepatitis: a childhood disease
No full textAn ivited review on Autoimmune hepatitis in childhoo
Long-term outcome of liver disease-related fibrinogen aguadilla storage disease in a child
No full textThe long-term outcome of liver disease-related fibrinogen Aguadilla storage disease in a child is reported
Autoimmune diseases of the liver and biliary tract
No full textA volume update on liver diseases in childre
Hepatitis B "by proxy" an emerging presentation of chronic hepatitis B in children
No full textSix adopted asymptomatic children in whom chronic HBV infection was identified through the occurrence of an acute hepatitis B in a family member. All of the children had serum HBV-DNA >2000 pg/mL. Acute hepatitis B in a family should alert the physician regarding the possibility of existing chronic HBV infection in other members of the family, especially newly adopted children, leading to a quick evaluation of their HBV status and to an efficacious protection of susceptible family member
The inflammatory bowel disease (IBD) associated to autoimmune sclerosing cholangitis (ASC) in children: clinical endoscopic and histological features in a cohort of 49 patients
No full textSteroid free treatment in autoimmune hepatitis: Is azathioprine monotherapy truly a viable option to obtain remission?
No full textNo abstract availabl
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