939 research outputs found
The Villa del Pigneto Sacchetti
No full textThe Villa del Pigneto Sacchetti / Jörg M. Merz ; Anthony F. Blunt. - In: Society of Architectural Historians: Journal of the ... 49. 1990. S. 390-40
Sacchetti
No full textBarberini. - Sacchetti. - In: Die großen Familien Italiens / hrsg. von Volker Reinhardt. - Stuttgart : Kröner, 1992. - S. 43-53, 463-467. - (Kröners Taschenausgabe ; 485
Potenziali usi salutistici di droghe amazzoniche e autoctone: fingerprinting, bioattività e sicurezza
No full textLe miscele terpeniche sono il frutto di strategie estrattive associate a particolari droghe di prevalente origine vegetale, come quelle indicate come oggetto del presente progetto nel paragrafo delle Motivazioni dell'aggregazione. Di rilevante interesse farmaceutico sono gli oli essenziali, miscele prevalentemente a carattere mono- e sesquiterpenico, ampiamente utilizzati nel settore del farmaco, parafarmaco e del prodotto erboristico per trattare numerose affezione di blanda e moderata gravità, così come lo sono le droghe da cui essi derivano come documentato anche dall’ampia letteratura etno-farmaco-botanica (Burt S. Essential oils: their antibacterial properties and potential applications in foods—a review. Int. J. Food Microbiol. 94(3): 223-253, 2004; Essential Oil Desk Reference, Essential Science Publishing, 2007).
La ricerca nell’ambito delle miscele terpeniche è sempre stata ricca ed incentrata prevalentemente sulla caratterizzazione chimica e sulla determinazione della bioattività, quest’ultima soprattutto focalizzata su saggi di attività antibiotica ed antiossidante con microrganismi di varia natura (Sacchetti et al. Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chem. 91: 621–632, 2005; ).
Recente sviluppo degli studi su queste miscele è l’individuazione ed isolamento delle principali classi terpeniche responsabili dell’attività e, soprattutto, la caratterizzazione e quantificazione degli aspetti di sinergia tra i diversi componenti che sono alla base dell’efficacia e della sicurezza farmaceutica, anche in relazione ad un più vasto e più inedito spettro di bioattività, come aspetti correlati all’interazione molecola-acidi nucleici e con l’espressione genica (Guerrini et al. Bergamot (Citrus bergamia Risso) Fruit Extracts as γ-Globin Gene Expression Inducers: Phytochemical and Functional Perspectives. J. Agric. Food Chem. 57: 4103–4111, 2009; Borgatti M, Mancini I, Bianchi N, Guerrini A, Lampronti I, Rossi D, Sacchetti G, Gambari R. Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines BCM Biochemistry, 15-27, 2011), o come all'espressione di mutageno-protezione (Bruni et al. Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark. Fitoterapia 77: 538–545, 2006; Guerrini et al. Bioactivities of Piper aduncum L. and Piper obliquum Ruiz & Pavon (Piperaceae) essential oils from Eastern Ecuador. Environmental Toxicology and Pharmacology, 27, 39-48, 2009; Rossi D., Mares D., Romagnoli C., Andreotti E., Manfredini S., Vicentini C.B. Antidermatophytic activity of pyrazolo[3,4-c]isothiazoles: a preliminary approach on 4-chlorophenyl derivative for evaluation of mutagenic and clastogenic effects on bacteria and human chromosomes in vitro Drug and Chemical Toxicology, 34(3), 324-331, 2011)
Nonspecific provocation of target organs in allergic diseases: EAACI-GA(2)LEN consensus report
No full textAllergy. 2007 Jun;62(6):683-94. Nonspecific provocation of target organs in allergic diseases: EAACI-GA(2)LEN consensus report. Bonini S, Rasi G, Brusasco V, Carlsen KH, Crimi E, Popov T, Schultze-Werninghaus G, Gramiccioni C, Bonini M, Passali D, Bachert C, van Cauwenberge PB, Bresciani M, Bonini S, Calonge M, Montan PG, Serapiao Dos Santos M, Belfort R Jr, Lambiase A, Sacchetti M. Source Second University of Naples, Naples, Italy. Abstract It is widely accepted that nonspecific tissue reactivity is a distinct pathophysiological hallmark of allergic diseases, influenced by genetic and environmental factors different from those involved in causing sensitization and allergen response of target organs. This consensus document aims at reviewing procedures currently used for nonspecific provocation of the bronchi, nose and eye and for measuring their responsiveness to nonspecific stimuli. PMID: 17508974 [PubMed - indexed for MEDLINE
La forma del mondo
No full textProgetto per le Latomie dei Cappuccini di Siracusa.
Il progetto è stato elaborato nell’ambito delle attività disciplinari del Dottorato di Ricerca in Composizione Architettonica – Scuola di Dottorato in Ingegneria Civile ed Architettura – XXI ciclo – attivato presso la Facoltà di Architettura “Aldo Rossi” (docenti del gruppo di progettazione: Francesco Gulinello, Elena Mucelli, Stefania Rossl, Annalisa Trentin; dottorandi: Claudia Cagneschi, Roberto Fabbri, Giovanni Poletti, Raffaella Sacchetti. Hanno partecipato alla redazione degli elaborati per la mostra: Letizia Biondi, Valentina Graziani, Lorena Pulelli, Antonella Salvatori)
Time to reconsider how ventilation is regulated above the respiratory compensation point during incremental exercise
No full textThe regulation of ventilation during incremental exercise beyond the respiratory compensation point (RCP) has traditionally been attributed to metabolic acidosis-driven stimulation of chemoreceptors. However, emerging evidence suggests that this explanation may be incomplete. In this review, we analyze the ventilatory response above RCP, emphasizing the disproportionate increase in minute ventilation () relative to carbon dioxide output (). We propose that this response is primarily driven by a nonlinear increase in respiratory frequency (), rather than tidal volume (). This distinction challenges conventional models of ventilatory control and suggests that mechanisms beyond metabolic acidosis, such as cortical drive and sensory feedback, may play a more significant role in modulating ventilation during high-intensity exercise. A re-evaluation of ventilatory regulation incorporating these factors could enhance our understanding of exercise physiology and improve interpretations of ventilatory thresholds in both research and clinical settings
Social regeneration and local development: Cooperation, social economy and public participation
No full text
The ARPAL atmospheric operational modeling chain and its applications: description and validation
No full textThe paper describes the model chain operational at the Meteo-Hydrological Center of the Liguria Region (ARPAL) based on the CNR-ISAC models BOLAM (BOlogna Limited Area Model) and MOLOCH (MOdello LOCale in Hybrid coordinates). Some of the chain applications and a statistical verification of its most recent implementation are also shown. The first operational run of the BOLAM numerical weather prediction (NWP) model at ARPAL was launched in September 1999, in correspondence with the beginning of the Mesoscale Alpine Programme Special Observing Period field campaign. Since then, the collaboration between CNR-ISAC and ARPAL has allowed to maintain and update the operational chain, also thanks to a continuous upgrade of the computational resources available at ARPAL. Since 2005, the non-hydrostatic model MOLOCH has been added to the forecasting chain.
In the present operational setup, BOLAM is run over a European domain at the horizontal resolution of about 8 km, using ECMWF-IFS analysis and forecasts as initial and boundary conditions. MOLOCH model is nested in BOLAM, and it runs over a domain including the entire Italian territory, on a 1.5-km horizontal resolution grid. The forecast products, consisting in 72-h BOLAM and 48-h MOLOCH predictions, are available in 1.5 h after the reception of the ECMWF-IFS data. Four runs every day are performed.
Other modeling systems in cascade are driven by NWP models. For several years, wind fields obtained from the atmospheric modeling chain have been used to force the wave model WAVEWATCH III, implemented at different resolutions over the Mediterranean basin. Other applications in cascade consist in hydrological prediction for the basins of the Liguria Region, wildfire, and ocean circulation modeling. Moreover, the different ini- tializations of the BOLAM and MOLOCH models provide an important contribution to the ARPAL operational Poor Man’s Ensemble prediction system.
A verification based on 3 years of data available from the ARPAL ground observing net- work shows a general capability of the high-resolution models in better forecasting heavy precipitation events, due to a better description of convective phenomena, while a less marked improvement with respect to large-scale models is shown for low precipitation thresholds. Results also show an improvement of model performance for all monitored variables, precipitation, 2-m temperature, and 10-m winds, when resolution increases and when model domains are enlarged
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