156 research outputs found
How to achieve esthetics in compromised sites
No full textSeverely resorbed edentulous ridges represent a challenge for implant-supported dental restorations, both from an esthetic and functional point of view, due to the lack of alveolar bone and unfavorable local conditions which may compromise the final outcome of rehabilitation, such as unfavorable intermaxillary relationship, lack of attached gengiva, excetera. The objective of this presentation is to show the present possibilities in restoring alveolar defects by means of autogenous bone grafts (both standard grafts and revascularized bone transplants), distraction osteogenesis, and osteotomies, in association with or followed by the placement of dental implants, highlighting indications, possibilities, and limits of different surgical options as well as survival and success rates of implants placed in reconstructed site
Reliability of dental calcification compared to hand-wrist X-ray to evaluate skeletal maturation in growing subjects: a systematic review
No full textIl trattamento di pazienti con perdita di di supporto parodontale e/o con atrofie ossee
No full textLo sviluppo delle tecniche di rigenerazione tissutale ha reso possibile il recupero funzionale di molti denti con elevata distruzione parodontale. Il dentista, pertanto, si pone il quesito se cercare di mantenere il dente o sostituirlo con un impianto. Alla base del successo terapeutico c’è sempre un accurato inquadramento diagnostico. Nell’ambito della presentazione verranno mostrati diversi casi per guidare il clinico nel corretto orientamento prognostico. Numerosi studi clinici hanno confermato che la percentuale di successo implantare, anche a lungo termine, è elevata. Tuttavia la presenza di una quantità insufficiente di osso rende impossibile il posizionamento ottimale delle fixtures. Il clinico ha quindi il dovere di eseguire una corretta programmazione preoperatoria per evitare complicanze estetiche e/o funzionali. Nell’ambito della relazione, verranno presentati numerosi casi clinici con particolare attenzione alla corretta scelta della tecnica chirurgica sulla base di diversi fattori quali, ad esempio, il grado di riassorbimento osseo della cresta residua e/o la situazione parodontale dei denti adiacent
Ten-year results of a three-arm prospective cohort study on implants in periodontally compromised patients. Part 1: implant loss and radiographic bone loss
No full textOBJECTIVES: The aim of this study was to compare the long-term outcomes of implants placed in patients treated for periodontitis periodontally compromised patients (PCP) and in periodontally healthy patients (PHP) in relation to adhesion to supportive periodontal therapy (SPT). MATERIAL AND METHODS: One hundred and twelve partially edentulous patients were consecutively enrolled in private specialist practice and divided into three groups according to their initial periodontal condition: PHP, moderate PCP and severe PCP. Perio and implant treatment was carried out as needed. Solid screws (S), hollow screws (HS) and hollow cylinders (HC) were installed to support fixed prostheses, after successful completion of initial periodontal therapy (full-mouth plaque score or =3 mm, was, respectively, 4.7% for PHP, 11.2% for moderate PCP and 15.1% for severe PCP, with a statistically significant difference between PHP and severe PCP (P<0.05). Lack of adhesion to SPT was correlated with a higher incidence of bone loss and implant loss. CONCLUSION: Patients with a history of periodontitis presented a lower survival rate and a statistically significantly higher number of sites with peri-implant bone loss. Furthermore, PCP, who did not completely adhere to the SPT, were found to present a higher implant failure rate. This underlines the value of the SPT in enhancing the long-term outcomes of implant therapy, particularly in subjects affected by periodontitis, in order to control reinfection and limit biological complications
REGULATION OF CHROMOSOME SEGREGATION BY CONSERVED PHOSPHATASE CDC14 AND KINASE CDC5
No full textThe faithful transmission of the replicated genome from the mother to the daughter cell requires the correct establishment of linkages between the duplicated chromosomes (sister chromatids) and their bi-orientation on the mitotic spindle. Chromosome segregation initiates only after each sisters pair is correctly aligned onto the microtubules emanating from the spindle poles. Next, Esp1-mediated cleavage of cohesin is required to trigger anaphase onset while the physical segregation of the separated sisters is next driven by spindle activity. However, this scenario appears to be more complicated involving additional factors driving the sister chromatid segregation process (i.e. the Top2-mediated resolution of replication catenates). In budding yeast, anaphase progression and exit from mitosis require the protein phosphatase Cdc14 whose activation relies on two consecutive protein pathways, the FEAR network and the MEN. As the polo-like kinase Cdc5 is a component of both pathways its activity is essential to Cdc14 release and in its absence Cdc14 is never released.
By combining loss-of-function alleles of Cdc5 and Cdc14 we obtained double mutant cells that had cohesin cleaved but still arrested with undivided nuclei and short bipolar spindles. Anaphase spindle elongation initiates quickly after cohesin removal (anaphase A) and then switches to a slower elongation rate (anaphase B) due to changes in spindle behaviour mediated by motor proteins and microtubule-associated enzymes. Although some residual cohesion between sister chromatids seems to contribute to the terminal phenotype of cdc14 cdc5 cells, our data indicate that anaphase B is the main mitotic defect of these cells.
We conclude that Cdc5 and Cdc14 are redundantly involved in activating spindle activity following cohesion resolution, suggesting the existence of a regulatory network that coordinates sister chromatid separation with spindle elongation after cohesin cleavage. Importantly, we identified the motor protein Cin8 as a (direct or indirect) target of Cdc5 in the regulation of spindle elongation
Type i collagen-based devices to treat nerve injuries after oral surgery procedures. A systematic review
No full textThe regeneration of nerve injuries after oral surgery procedures is a quite often attempted procedure in dental medicine. Despite several proposed technical approaches, there is still a lack of consensus on which should be considered the gold standard procedure, even-though in the last decades, the use of collagen-based devices allowing a tension-free direct neurorrhaphy has been used. A systematic search of multiple electronic databases and hand searching was conducted to assess the level of evidence behind the use of type I collagen devices to treat nerve injuries after oral surgery procedures. After screening, four articles (one case series and three retrospective studies) including overall 65 patients suffering from inferior alveolar (IAN)/lingual nerve (LN) injury after mandibular wisdom tooth extraction, met the inclusion criteria and could be included. The Oxford Centre for evidence-based medicine (OCEBM) scaling system was used to evaluate the quality of the included studies. Positive clinical results in terms of sensorial improvements were recorded at least 3 months after surgery, even-though the overall level of evidence is low. The use of collagen membranes to enhance nerve regeneration in oral surgery results in promising results. Nevertheless, additional clinical comparative trials with larger sample sizes are needed
Osservazioni archeo-topografiche sull’insediamento d’altura nel territorio ibleo (Sicilia sud-orientale): il caso di Monte Casasia
No full textM. Casasia as a case study. New data from reconnaissance surveys and remote sensing - Paper’s aim is to demonstrate how the integrated use of remote and proximal sensing improves the reconstruction of ancient uplands settlements’ topography. For this purpose, the case study is the territory of the western sector of the Hyblean Plateau (Southeastern Sicily), where a sector of the cultural frontier-land between indigenous people and Greeks was located. The field surveys carried out were integrated with the synoptic analysis of remotely (aerial photographs, DTM, satellite images) and proximally sensed data, with the systematic coverage by drone footage of one case study, Monte Casasia (Monterosso Almo), key site in the Hyblean settlement system in the Greek era that was not urbanised in later periods
Subepithelial connective tissue graft for treatment of gingival recessions with and without enamel matrix derivative: a multicenter, randomized controlled clinical trial
No full textThe aim of this multicenter, randomized controlled trial was to compare the clinical outcomes of a connective tissue graft (CTG) alone or in combination with enamel matrix derivative (CTG + EMD) in the treatment of Miller Class I and II gingival recessions. The 56 selected defects were evaluated for probing depth, recession depth, keratinized tissue width, and probing attachment level, and were measured at baseline and 12 months after treatment. The mean recession reduction was 3.9 ± 0.8 mm for EMD-treated sites (test) and 3.6 ± 1.5 mm for the control group (P = .22), corresponding to a mean root coverage of 90% and 80% for test and control groups, respectively (P = .05). Complete root coverage was obtained in 62% of test sites compared to 47% in the control group (P = .27). Both procedures provided good soft tissue coverage. The better results of the test group did not achieve a statistically significant level
Sub-Epithelial Connective Tissue Graft for Treatment of Gingival Recessions with and without Enamel Matrix Derivative. A multicentre, randomized controlled clinical trial
No full textThe aim of this multi-centre, randomized controlled trial was to compare the clinical outcomes of Connective Tissue Graft alone (CTG) or in combination with Enamel Matrix Derivative (CTG+EMD) in the treatment of Miller Class I and II gingival recessions. The 56 selected defects were evaluated for probing depth (PD), recession depth (RD), keratinized tissue width (KT) and probing attachment level (PAL) and were measured at baseline and 12 months after treatment. The mean recession reduction was 3.9 ± 0.8 mm for the EMD-treated sites (test) and 3.6 ± 1.5 mm for the control group (p=0.22), corresponding to a mean root coverage of 90% and 80% for the test and control respectively (p=0.05). Complete root coverage could be obtained in 62% of the test sites versus 47% in the control (p=0.27). In conclusion, both procedures provided good soft tissue coverage. The better results of the test group did not achieve a statistical significance leve
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