2,465 research outputs found
Extracting vital signs with smartphone camera
No full textDesarrollo de una app para sistema operativo Android. Hallar mediante la cámara de un dispositivo móvil el pulso de un paciente. Se utilizarán técnicas de procesado de imagen y la librería openCV.García Plo, M. (2016). Extracting vital signs with smartphone camera. https://riunet.upv.es/handle/10251/80419.TFG
The PLO reforms and outcomes for children
No full textAn overview for children's guardians of the Establishing Outcomes of care proceedings for children before and after care proceedings reform Study. The PLO reduced use of experts and halved case duration, compared with a random sample of cases brought by the same 6 Local Authorities in 2009-10. Final orders also differed, largely due to the case of Re B-S (2013). Fewer children remained in care after the end of care proceedings because of the greater use of SGOs and SOs but return to court after SOs was high - at least 25% of cases in the samples taken together
AMČR - dokument M-TX-202300045
No full textStav: 3Označení: Žarošice RD Kubín plotPopis: Žarošice RD plo
The PLO reforms and outcomes for children
No full textAn overview for children's guardians of the Establishing Outcomes of care proceedings for children before and after care proceedings reform Study. The PLO reduced use of experts and halved case duration, compared with a random sample of cases brought by the same 6 Local Authorities in 2009-10. Final orders also differed, largely due to the case of Re B-S (2013). Fewer children remained in care after the end of care proceedings because of the greater use of SGOs and SOs but return to court after SOs was high - at least 25% of cases in the samples taken together
The Legal Effects of the Israeli-PLO Declaration of Principles: Steps Toward Statehood for Palestine
No full textThis Comment argues that the Declaration of Principles falls short of establishing a state of Palestine during the interim period provided for in the Declaration. However, this Comment presents the possibility that a state of Palestine will be established after the interim period. If a state of Palestine is established, it will have an effect on current United States law regarding Palestine and the PLO\u27s sovereign immunity and standing to sue. The Declaration of Principles presents an opportunity to reevaluate the traditional view of Palestine. This Comment examines the Israeli-PLO Declaration of Principles and its effect on the changing legal status of Palestine. Although the provisions of the Declaration do provide steps toward establishing the requirements of statehood for Palestine, the Declaration does not establish a state of Palestine during the five-year interim period of autonomy. However, it is possible that a state of Palestine could exist after the interim period
Vehicle effects on in vitro transdermal absorption of sevoflurane in the bullfrog, Rana catesbeiana
No full textThe experimental objectives were to identify a vehicle which produces a homogenous formulation when combined with the anesthetic solution sevoflurane and understand the dermal absorption of sevoflurane in silastic membranes and amphibian skin in vitro utilizing a flow-through diffusion system. Seven vehicles were evaluated in varying ratios with 5 formulations resulting in the desired homogenous consistency for practical application. Sevoflurane diffusion across silastic membranes was influenced by pluronic/lecithin organogel (PLO), pluronic F 127 20% gel, and sterile lube. Flux and permeability across silastic membranes were significantly greater in sterile lube than in the other formulations. While no significant vehicle effects were observed in bullfrog skin, the flux-time profiles suggest that sevoflurane diffusion in bullfrog skin may be positively influenced by PLO. Future in vivo studies are required to assess sevoflurane retention after removal of these formulations to more accurately control the plane of anesthesia in amphibians
From the river to the sea? : honour, identity and politics in historical and contemporary Palestinian rejectionism
No full textThe present thesis seeks to understand and explain the rhetoric and
behaviour of the rejectionist 'current' within the Palestinian national
movement. It proceeds from the view that extant scholarship, primarily from
within the fields of terrorism and security studies, has profoundly
misunderstood rejectionist speech and behaviour by ignoring the
explanatory capacity of Emic - the research subject's perception - as well as
the influence of the sociocultural milieu within which rejectionism exists.
The thesis proceeds to set up a 'socioculturally sensitive' analytical
framework drawn from social identity theory, a heuristic, non-reductionist
model for understanding group interaction and conflict. Emphasizing
cultural norms and cues identified by anthropologists as salient in the
eastern Mediterranean, the thesis suggests that the social value of honour,
patron-client dynamics and a firmly entrenched group orientation must be
significant elements of a model for understanding rejectionist behaviour.
The main analytical narrative suggests that for reasons derived from
ideology, patron-client relations and group dynamics, what has distinguished
the rejectionists from the mainstream have been a qualitatively different set
of preconditions for, and objectives of diplomatic negotiations. To the main
rejectionist factions the goal of liberating Palestine has always been
inextricably intertwined with the goal of restoring national honour; one
without the other has been impossible and to claim otherwise would mean a
depletion of factional and personal honour. To the rejectionists, there has
never been any question of deviating from the fundamental goals - national
recognition, repatriation, self-determination and independent statehood, not
even for tactical reasons. This 'higher standard' likely derives from their
structurally and politically subordinate position within the national
movement, and the need to creatively enhance their own social status and
appeal
Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes
No full textThe virulence of many Gram-positive bacteria depends on cholesterol-dependent cytolysins (CDCs), which form pores in eukaryotic cell plasma membranes. Pyolysin (PLO) from Trueperella pyogenes provided a unique opportunity to explore cellular responses to CDCs because it does not require thiol activation. Sublytic concentrations of PLO stimulated phosphorylation of MAPK ERK and p38 in primary stromal cells, and induced autophagy as determined by protein light-chain 3B cleavage. Although, inhibitors of MAPK or autophagy did not affect PLO-induced cytolysis. However, 10 μM 3-hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide (Dynasore), a dynamin guanosine 5′-triphosphatase inhibitor, protected stromal cells against PLO-induced cytolysis as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (85 ± 17% versus 50 ± 9% cell viability), measuring extracellular ATP, and kinetic assays. This was a generalized mechanism because Dynasore also protected HeLa cells against streptolysin O. Furthermore, the effect was reversible, with stromal cell sensitivity to PLO restored within 30 minutes of Dynasore removal. The protective effect of Dynasore was not conferred by dynamin inhibition, induction of ERK phosphorylation, or Dynasore binding to PLO. Rather, Dynasore reduced cellular cholesterol and disrupted plasma membrane lipid rafts, similar to positive control methyl-β-cyclodextrin. Dynasore is a tractable tool to explore the complexity of cholesterol homeostasis in eukaryotic cells and to develop strategies to counter CDCs.—Preta, G., Lotti, V., Cronin, J. G., and Sheldon, I. M. Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes
Pharmacokinetics of cyclosporine A in normal and carrier dogs for Alport Syndrome and transdermal absorption of cyclosporine A in normal dogs
No full textDue to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references (leaves 58-66).Issued also on microfiche from Lange Micrographics.Cyclosporine A is a fungal 11 amino acid cyclic polypeptide characterized by potent immunosuppressive activity. CsA selectively inhibits T lymphocytes, without any direct effect on B lymphocytes. Allograft and patient survival rates for all solid organ transplant recipients have improved significantly since CsA was introduced for clinical use. CsA is also effective in the treatment of autoimmune diseases. After oral administration, CsA is extensively metabolized by the cytochrome P-450IIIA enzyme systems in the small intestines and the liver and then excreted in the bile. Oral bioavailability of CsA is markedly variable among patients, necessitating drug monitoring. CsA has a narrow therapeutic window, whereas low concentrations are ineffective, slightly high concentrations can be nephrotoxic or hepatotoxic. The pharmacokinetics of CsA changes in some disease states due to alterations in blood binding properties of CsA. One objective of this study was to determine the pharmacokinetics of CsA in apparently healthy normal dogs and in carrier dogs for Alport syndrome, and to compare the pharmacokinetics of CsA between the two groups after single oral administration. There were no differences in CsA pharmacokinetics between apparently normal dogs and carrier female dogs for Alport syndrome. Hematocrit, serum cholesterol and plasma protein concentrations in dogs with Alport syndrome were within normal ranges, which was consistent with the finding that CsA pharmacokinetics were unchanged. Topical administration of CsA in dermatologic disorders may be more convenient than oral administration. Its large molecular weight, ring structure, and high lipophilicity make its transdermal absorption difficult. The objectives of this study were; 1) to determine availability of transdermal CsA when applied topically in pleuronic lecithine gel (PLO); 2) to determine the dose and formulation of CsA in the transdermal gel system necessary to achieve therapeutic concentrations; 3) to determine the relative (compared with oral) bioavailability of CsA PLO gel in dogs. In this study CsA PLO gel failed to provide transdermal absorption of CsA
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