2,949 research outputs found
Some comments about A Bayesian criterion for singular models by M. Drton and M. Plummer
No full textThese are written comments about the Read Paper A Bayesian criterion for singular models by M. Drton and M. Plummer, read to the Royal Statistical Society on October 5, 2016. The discussion was delivered by Judith Rousseau
Some comments about A Bayesian criterion for singular models by M. Drton and M. Plummer
No full textThese are written comments about the Read Paper A Bayesian criterion for singular models by M. Drton and M. Plummer, read to the Royal Statistical Society on October 5, 2016. The discussion was delivered by Judith Rousseau
Stress ulceration: prevalence, pathology and association with adverse outcomes
No full textMark P Plummer, Annika Reintam Blaser, Adam M Dean
A Bayesian hierarchical framework to integrate dietary exposure and biomarker measurements into aetiological models
No full textIn nutritional epidemiology, self-reported assessments of dietary exposure are prone to measurement errors, which is responsible for bias in the association between dietary factors and risk of disease. In this study, self-reported dietary assessments were complemented by biomarkers of dietary intake. Dietary and serum measurements of folate and vitamin-B6 from two nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC) study were integrated in a Bayesian model to explore the measurement error structure of the data, and relate dietary exposures to risk of site-specific cancer. A Bayesian hierarchical model was developed, which included: 1) an exposure model, to define the distribution of unknown true exposure (X); 2) a measurement model, to relate observed assessments, in turn, dietary questionnaires (Q), 24-hour recalls (R) and biomarkers (M) to X measurements; 3) a disease model, to estimate exposures/cancer relationships. The marginal posterior distribution of model parameters was obtained from the joint posterior distribution, using Markov Chain Monte Carlo (MCMC) sampling techniques in JAGS. The study included 554 and 882 case/control pairs for kidney and lung cancer, respectively. In the measurement error component, the error correlation between Q measurements of vitamin-B6 and folate was estimated to be equal to 0.82 (95% CI: 0.76, 0.87). After adjustment for age, center, sex, BMI and smoking status, the kidney cancer odds ratios (OR) were 0.55 (0.16, 1.31) and 1.07 (0.33, 3.44) for one standard deviation increase of vitamin-B6 and folate, respectively. For lung cancer ORs were 0.85 (0.27, 2.42) for vitamin-B6 and 0.55 (0.14, 1.39) for folate. Bayesian models offer powerful solutions to handle complex data structures. After accounting for the role of measurement error, folate and vitamin-B6 were not associated to the risk of kidney and lung cancer
Economic Development in China and Its Implications for East Asia
No full textEconomic development in China, East Asia, trade adjustment
On the physical aspects that control mechanical deformation in bulk metallic glasses
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Dysglycemia and glucose control during sepsis
No full textSepsis predisposes to disordered metabolism and dysglycemia; the latter is a broad term that includes hyperglycemia, hypoglycemia, and glycemic variability. Dysglycemia is a marker of illness severity. Large randomized controlled trials have provided considerable insight into the optimal blood glucose targets for critically ill patients with sepsis. However, it may be that the pathophysiologic consequences of dysglycemia are dynamic throughout the course of a septic insult and also altered by premorbid glycemia. This review highlights the relevance of hyperglycemia, hypoglycemia, and glycemic variability in patients with sepsis with an emphasis on a rational approach to management.Mark P. Plummer, Adam M. Dean
Bulletin, geologic series 21
No full textThe work of establishing additional bench marks throughout the State for the use of engineers and others was confirmed during the field season of 1919. It was in immediate charge of Mr. Loren P. Plummer, Jr., who, under the direction of Mr. C. C. Vermeule, had in previous years run many of the lines described in Bulletin 17 and 19. The work was done with the same degree of accuracy as obtained in the earlier levels and as set forth in detail in these bulletins
Synthesis, structure, and optical properties of Pt(II) and Pd(II) complexes with oxazolyl- and pyridyl-functionalized DPPM-type ligands : a combined experimental and theoretical study
No full textNew square-planar complexes [Pt(1-H)2] (2a) [1-H = (oxazolin-2-yl)bis(diphenylphosphino)methanide] and [Pd(1-H)2] (2b), of general formula [M{(Ph2P)2C - -C - -NCH2CH2O}2] (M = Pt, 2a; M = Pd, 2b), result from deprotonation of 2-{bis(diphenylphosphino)methyl}oxazoline (1) at the PCHP site. The new, functionalized dppm-type ligand 4-{bis(diphenylphosphino)methyl}pyridine, (Ph2P)2CH(4-C5H4N) (4), was prepared by double lithiation and phosphorylation of 4-picoline. In the presence of NEt3, the reactions of 2 equiv of 4 with [PtCl2(NCPh)2] and [Pd(acac)2] (acac = acetylacetonate) afforded [Pt(4-H)2] (5a) [4-H = bis(diphenylphosphino)(pyridin-4-yl)methanide] and [Pd(4-H)2] (5b), of general formula [M{(Ph2P)2C(4-C5H4N)}2] (M = Pt, 5a; M = Pd, 5b), respectively. In the absence of base, the reactions of 2 equiv of 4 with [PtCl2(NCPh)2] and [PdCl2(NCPh)2] afforded (5a·2HCl) (6a) and (5b·2HCl) (6b), respectively, in which the PCHP proton of 4 has migrated from carbon to nitrogen to give a pyridinium derivative of general formula [M{(Ph2P)2C(4-C5H4NH)}2]Cl2 (M = Pt, 6a; M = Pd, 6b). The complexes 3a, 5a·2MeOH, and 6b·4CH2Cl2 have been structurally characterized by X-ray diffraction. The absorption/emission properties of the Pt(II) complexes 2a and 5a and the Pd(II) complexes 2b and 5b have been investigated by UV-vis spectroscopy and theoretical analysis based on density functional theory. The UV-vis absorption spectra of the neutral complexes recorded in dilute N,N′-dimethylformamide solutions are dominated by intense spin-allowed intraligand transitions in the region below 350 nm. The complexes exhibit charge-transfer bands between 350 and 500 nm. The experimental and theoretical absorption spectra agree qualitatively and point to two low-lying ligand-to-metal charge transfer states that contribute to the bands observed between 350 and 500 nm. The complexes are emissive in frozen solutions at 77 K, in the pure solid state, and when doped into films of poly(methyl methacrylate) but are nonemissive in solution. A red shift is observed when Pt(II) is replaced by Pd(II)
The Plummer system of genealogical enumeration : lineage of Mr. Francis Plumer, Newbury, Massachusetts, 1635.
No full text64 p.
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