28 research outputs found
Metamorphic history and geodynamic significance of the Early Cretaceous Sabzevar granulites (Sabzevar structural zone, NE Iran)
No full textThe Iranian ophiolites are part of the vast orogenic suture zones that mark the Alpine-Himalayan convergence zone. Few petrological and geochronological data are available from these ophiolitic domains, hampering a full assessment of the timing and regimes of subduction zone metamorphism and orogenic construction in the region. This paper describes texture, geochemistry, and the pressure-temperature path of the Early Cretaceous mafic granulites that occur within the Tertiary Sabzevar ophiolitic suture zone of NE Iran. Whole rock geochemistry indicates that the Sabzevar granulites are likely derived from a MORB-type precursor. They are thus considered as remnants of a dismembered dynamo-thermal sole formed during subduction of a back-arc basin (proto-Sabzevar Ocean) formed in the upper-plate of the Neotethyan slab. The metamorphic history of the granulites suggests an anticlockwise pressure-temperature loop compatible with burial in a hot subduction zone, followed by cooling during exhumation. Transition from a nascent to a mature stage of oceanic subduction is the geodynamic scenario proposed to accomplish for the reconstructed thermobaric evolution. When framed with the regional scenario, results of this study point to diachronous and independent tectonic evolutions of the different ophiolitic domains of central Iran, for which a growing disparity in the timing of metamorphic equilibration and of pressure-temperature paths can be expected to emerge with further investigations
Studies of locomotor network neuroprotection by the selective poly(ADP-ribose) polymerase-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro
No full textelayed neuronal destruction after acute spinal injury is attributed to excitotoxicity mediated by hyperactivation of poly(ADP-ribose) polymerase-1 (PARP-1) that induces 'parthanatos', namely a non-apoptotic cell death mechanism. With an in vitro model of excitotoxicity, we have previously observed parthanatos of rat spinal cord locomotor networks to be decreased by a broad spectrum PARP-1 inhibitor. The present study investigated whether the selective PARP-1 inhibitor N-(6-oxo-5,6-dihydrophenanthridin-2-yl)(N,N-dimethylamino)acetamide center dot HCl (PJ-34) not only protected networks from kainate-evoked excitotoxicity, but also prevented loss of locomotor patterns recorded as fictive locomotion from lumbar (L) ventral roots (VRs) 24 h later. PJ-34 (60 mu m) blocked PARP-1 activation and preserved dorsal, central and ventral gray matter with maintained reflex activity even after a large dose of kainate
Effects of 6(5H)phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord
No full textKainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord
No full textEarly Cretaceous migmatitic mafic granulites from the Sabzevar range (NE Iran): implications for the closure of the Mesozoic peri-Tethyan oceans in central Iran
No full textThe ophiolitic mélange of the Sabzevar Range (northern Iran) is a remnant of the oceanic basins on the northern margin of the Neotethys that were consumed during the Arabia-Eurasia convergence history. Occurrence of km-scale, dismembered mafic HP granulitic slices is reported in this study. Granulites record an episode of amphibole-dehydratation melting and felsic (tonalite/throndhjemite) melt segregation at c. 1.1 GPa and 800 °C. In situ U(-Th)-Pb geochronology of zircon and titanite grains hosted in melt segregations points to an Early Cretaceous (Albian) age for the metamorphic climax. Results of this study (i) impose reconsideration of the current paleotectonic models of the Neothetyan convergent margin during the Early Cretaceous, and (ii) argue that punctuated events of subduction of short-lived back-arc oceanic basins accompanied the long-lasting history of the Neotethyan subduction in the region
Early carboniferous subduction-zone metamorphism preserved within the Palaeo-Tethyan rasht ophiolites (Western Alborz, Iran)
No full textA polyphase history of oceanic construction and consumption is documented by the distribution of the Tethyan ophiolitic suture zones in Iran. Despite the geodynamic significance of these suture zones, few modern petrological and geochronological data are available from these ophiolitic domains, hampering a full assessment of the timing, thermobaric regimes and palaeotectonic scenarios leading to oceanic suturing and continental assembly in Iran and, more in general, along the southern margin of Eurasia. In this paper, we describe a newly discovered HP ophiolite mélange within the Rasht ophiolites, at the NW termination of the Palaeo-Tethyan suture in Iran. Petrological investigations on the metamorphic units embedded within the ophiolite mélange are integrated with whole-rock geochemistry and Ar-Ar phengite geochronology to constrain the geotectonic setting of formation and to define the associated P-T-t paths.We provide evidence that the Rasht ophiolite domain corresponds to an exhumed subduction complex formed during Early Carboniferous (c. 350 Ma) subduction of a branch of the Palaeo-Tethyan oceanic realm, with peak metamorphism equilibrated under blueschist-to eclogite-facies metamorphic conditions. Implications of these data for the palaeotectonic reconstruction during closure of the Palaeo-Tethyan ocean and the terminal collisional assembly along the southern margin of the Eurasia plate are also discussed
Adakite differentiation and emplacement in a subduction channel: The late paleocene Sabzevar magmatism (NE Iran)
No full textThis study describes the structural setting, petrogenesis, and geochronology of a suite of acidic magmatic rocks that are intruded in the metamorphic core of the Tertiary ophiolitic suture zone of the Sabzevar Range, NE central Iran. These intrusive bodies show tabular geometries with solid-state fabrics documenting syntectonic emplacement during crustal shortening. In the total alkalis-silica (TAS) diagram, their compositions define a medium-K calc-alkaline suite, spanning from basaltic andesite to the dacite and rhyolite fields. They show characteristic low MgO (0.15-0.60 wt%) and Ni (<20 ppm), high Sr contents, a negligible Eu anomaly, and extremely fractionated rare earth element (REEs), with high La/Yb and Sr/Y (up to 900) ratios, but very low Yb and Y contents. They also show zircon Hf isotope compositions compatible with a mid-oceanridge basalt (MORB)-type oceanic crust. Inverse and forward thermobarometry constrains conditions of magma crystallization in the upper-pressure field of the amphibolite facies (ca. 1.2-1.5 GPa and 750 °C). Integrated U-Pb zircon and 40Ar/39Ar white mica and amphibole geochronology constrains the Sabzevar magmatism to the late Paleocene (at ca. 58 Ma). Genesis of the Sabzevar magmatic suite is interpreted in terms of prograde, wet amphibolite melting during oceanic subduction, within a pressure-temperature range between a plagioclase-out and a hornblende-out boundary. Magma differentiation and high-pressure amphibole fractionation of pristine slab melts are proposed as the dominant factors that imparted the adakite signature in the Sabzevar structural zone. Implications in terms of the regional tectonic scenario are discussed and framed within the advancing and retreating evolution of the Neotethyan subduction during the Mesozoic-Tertiary time span. © 2014 Geological Society of America
Tschermak fractionation in calc-alkaline magmas: the Eocene Sabzevar volcanism (NE Iran)
No full textCalc-alkaline arc magmatism at convergent plate margins is volumetrically dominated by metaluminous andesites. Many studies highlighted the importance of differentiation via fractionation processes of arc magmas, but only in the last decades, it has been demonstrated that not all rock-forming minerals may affect the evolution of calc-alkaline suites. In particular, a major role exerted by Al-rich hornblende amphibole as fractionating mineral phase has been documented in many volcanic arc settings. The aim of this work is to understand the role of the Tschermak molecule (CaAlAlSiO6) hosted in the hornblende and plagioclase fractionation assemblage in driving magma differentiation in calc-alkaline magmatic suites. We explore this issue by applying replenishment–fractional crystallization (RFC) and rare earth element–Rayleigh fractional crystallization (REE-FC) modeling to the Sabzevar Eocene (ca. 45–47 Ma) calc-alkaline volcanism of NE Central Iran, where hornblende-controlled fractionation has been demonstrated. Major element mass balance modeling indicates RFC dominated by a fractionating assemblage made of Hbl52.0–52.5 + Pl44.1–44.2 + Ttn3.3–3.9 (phases are expressed on total crystallized assemblage). REE-FC modeling shows, instead, a lower degree of fractionation with respect to RFC models that is interpreted as due to hornblende and plagioclase resorption by the residual melt. Calculations demonstrate that fractionation of the Tschermak molecule can readily produce dacite and rhyolite magmas starting from a calc-alkaline andesite source (FC = ca. 30 %). In particular, the Tschermak molecule controls both the heavy rare earth elements (HREE) and light rare earth element (LREE) budgets in calc-alkaline differentiation trends
Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake
No full textOveractivity of poly(ADP-ribose) polymerase enzyme 1 (PARP-1) is suggested to be a major contributor to neuronal damage following brain or spinal cord injury, and has led to study the PARP-1 inhibitor 2-(dimethylamino)-N-(5,6-dihydro-6-oxophenanthridin-2yl)acetamide (PJ-34) as a neuroprotective agent. Unexpectedly, electrophysiological recording from the neonatal rat spinal cord in vitro showed that, under control conditions, 1-60 mu M PJ-34 per se strongly increased spontaneous network discharges occurring synchronously on ventral roots, persisting for 24 h even after PJ-34 washout. The PARP-1 inhibitor PHE had no similar effect. The action by PJ-34 was reversibly suppressed by glutamate ionotropic receptor blockers and remained after applying strychnine and bicuculline. Fictive locomotion evoked by neurochemicals or by dorsal root stimulation was present 24 h after PJ-34 application. In accordance with this observation, lumbar neurons and glia were undamaged. Neurochemical experiments showed that PJ-34 produced up to 33% inhibition of synaptosomal glutamate uptake with no effect on GABA uptake. In keeping with this result, the glutamate uptake blocker TBOA (5 mu M) induced long-lasting synchronous discharges without suppressing the ability to produce fictive locomotion after 24 h. The novel inhibition of glutamate uptake by PJ-34 suggested that this effect may compound tests for its neuroprotective activity which cannot be merely attributed to PARP-1 block. Furthermore, the current data indicate that the neonatal rat spinal cord could withstand a strong, long-lasting rise in network excitability without compromising locomotor pattern generation or circuit structure in contrast with the damage to brain circuits known to be readily produced by persistent seizures. (C) 2012 Elsevier Ltd. All rights reserved
The calc-alkaline and adakitic volcanism of the Sabzevar structural zone (NE Iran): Implications for the Eocene magmatic flare-up in Central Iran
No full textA major magmatic flare-up is documented along the Bitlis-Zagros suture zone in Eocene-Oligocene times. The Cenozoic magmatism of intraplate Central Iran is an integrant part of this tectono-magmatic scenario. The Cenozoic magmatism of the Sabzevar structural zone consists of mostly intermediate to felsic intrusions and volcanic products. These igneous rocks have calc-alkaline and adakitic geochemical signatures, with nearly coincident zircon U-Pb and mica Ar-Ar ages of ca. 45 Ma. Adakitic rocks have quite low HREE and high Sr/Y ratio, but share most of their geochemical features with the calc-alkaline rocks. The Sabzevar volcanic rocks have similar initial Sr, Nd and Pb isotope ratios, showing their cogenetic nature. Nd model ages cluster tightly around ~. 0.2-0.3 Ga. The geochemistry of the Sabzevar volcanic rocks, along with their isotopic signatures, might strangle that an upper mantle source, metasomatized by slab-derived melts was involved in generating the Sabzevar calc-alkaline rocks. A bulk rock trace element modeling suggests that amphibole-plagioclase-titanite-dominated replenishment-fractional crystallization (RFC) is further responsible for the formation of the middle Eocene Sabzevar adakitic rocks. Extensional tectonics accompanied by lithospheric delamination, possibly assisted by slab break-off and melting at depth was responsible for the Eocene formation of the Sabzevar magmatic rocks and, more in general, for the magmatic "flare-up" in Iran
