511 research outputs found
Quiescenza e senescenza modulano l'espressione di EDF-1 in cellule endoteliali microvascolari
No full textPreliminary pathological results on chondrodysplastic dwarfism in Tyrolean Grey cattle due to deletion in the EVC2 gene
No full textPreliminary pathological results on chondrodysplastic
dwarfism in Tyrolean Grey cattle due to deletion
in the EVC2 gene
C Benazzi*, KE Dittmer†, KG Thompson†, C Drögemüller‡, A
Gentile*, LV Muscatello*, L Murgiano‡, C Piffer#, M Bolcato*
and B Brunetti*
*Department of Veterinary Medical Sciences, University of Bologna, 40064
Ozzano dell’Emilia, Italy. Email: [email protected]
†Institute of Veterinary, Animal and Biomedical Sciences, Massey University,
Private Bag 11222, Palmerston North 4442, New Zealand
‡Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern,
Switzerland.
#Gesundheitbezirk Bozen, Laura Conti Strasse 4, 39100 Bozen, Italy.
During July–November 2013 breeders reported the birth of
Italian Tyrolean Grey calves with abnormally short limbs. Seven calves, aged 2–5 months, were referred to the Department of Veterinary Medical Sciences, Bologna, Italy. Whole genome resequencing of an affected calf detected a single candidate causal mutation in the Ellis van Creveld syndrome 2 (EVC2) gene. All animals had difficulties in assuming or maintaining a quadrupedal stance, with deterioration in this ability with increased growth.
The limbs were disproportionately short and bulky, variably
rotated and arched in a dumbbell-like position. At necropsy, the limbs (in particular the femur and humerus) were rotated and significantly shortened. Histologically the growth plates of long bones and vertebrae were irregular and prematurely closed. The reserve zone showed variable thickness at the expense of proliferative and hypertrophic zones, which were disorganised with multifocal loss
of the normal columnar arrangement. In one calf reduced development of the heart valves was noted. In three female calves the genital tracts appeared fully mature, with numerous follicle-like structures
on the ovaries. The uteri had multiple polypoid structures
Near‐visible stereolithography of a low shrinkage cationic/free‐radical photopolymer blend and its nanocomposite
No full textIn this work, a newly prepared cationic/free-radical photopolymer, which consists of two epoxies and a tetrafunctional acrylate, is presented for the first time for a visible light stereolithography (SL), showing the advantages of both cationic and free-radical resins. An onium salt, commonly used as a cationic UV initiator, and a photosensitizer make the blend suitable for a near-visible (405 nm) SL. An increase in the polymerization rate and a drop in the induction period are observed for the newly prepared cationic/free-radical blend, compared with either only cationic systems or free-radical resins. This suggests that the combination of cationic and free-radical polymerizations in a single resin has a positive synergistic effect. The addition of silica nanoparticles to the blend provides a reinforcing and toughening effect. Indeed, the resin loaded with silica shows a 31% increase in the elastic modulus, compared with the unfilled resin. Regarding the values of tensile strength and elongation at break, they, respectively, grow by 47 and 15%, when the nanocomposite resin is compared with the neat resin. A very low volumetric shrinkage of 0.7% and a remarkable printing quality of objects obtained with this new photopolymer will enable the 3D printing of microrobots, bioengineering microdevices, and sensors. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48333
Masking level difference before and after surgery in unilateral otosclerosis
No full textThe object of this paper was to evaluate the binaural hearing in 20 patients suffering from unilateral otosclerosis. Binaural performance was assessed at a test frequency of 500 Hz using masking level difference (MLD) before and after surgery. The postsurgical results showed abnormal MLDs in patients in whom stapedotomy had successfully corrected the threshold asymmetry. Three possible hypotheses regarding this phenomenon were investigated: (1) cochlear damage, (2) auditory deprivation and (3) a mechanical middle ear anomaly due to the surgical prosthesis or healing processes. The analyses suggest that the conductive hearing loss may effect central auditory processing resulting in poor binaural hearing (auditory deprivation theory)
Meatotomy by the retrosigmoid approach to the cerebellopontile angle: an anatomo-surgical study].
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