236 research outputs found
Dispositivi cardiaci e possibili interferenze elettromagnetiche in ambito odontoiatrico
No full textObjectives: Many electromagnetic fields emitting equipments can potentially interfere with the activity of implantable heart-assist devices. The purpose of this work is to summarize data available in the literature about the possible interferences of common dental equipments with these devices. Materials and methods: PubMed database was searched using the following keywords: "cardiac devices", "electromagnetic interferences". Results and conclusions: Possible risks in hospitals, daily life and dental offices are reported. The most part of equipments analyzed are safe
I loop recorder impiantabili di nuova generazione possono essere gestiti in maniera sicura ed efficace da personale infermieristico formato
No full textIntroduction. Im-plantable plantable loop recorders (ILR) are recommended for several cardiac disorders: the recent miniaturization processes eased their implant and management. Aim. To describe the advantages of the ILR implant, patients' education and remote control performed by expert certified nurses. Methods. Retrospective analysis of consecutive ILR implants of our centre, preformed between May and December 2016: the complications occurred in patients implanted by doctors and nurses were described. Nurses were certified after a two days course and 3 implants assisted by a medical doctor. Results. 157 patients were implanted with a ICM Reveal LINQ (Med-tronic): 74 (47%) by physicians electrophysiologists and 83 (53%) out of the electrophysiology room, by certified nurses. The two groups of patients were not fully comparable because more complex patients were implanted by the physician. All the loop recorders were easily implanted adverse without events during the procedure and after 30 days. Two minor bleedings occurred 24 hours after the implant: 1 in a patient implanted by a physician and the other by a nurse. Both were rapidly solved by finger pressure. Conclusions. The ILR implants can be safely performed by trained nurses, out of the elettrophysiology room, with benefits for the patients and the hospital
Epigenetic Mechanisms of Epidermal Differentiation
No full textKeratinocyte differentiation is an essential process for epidermal stratification and stratum corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start their differentiation by changing their functional or phenotypical type; this process is regulated via induction or repression of epidermal differentiation complex (EDC) genes that play a pivotal role in epidermal development. Epidermal development and the keratinocyte differentiation program are orchestrated by several transcription factors, signaling pathways, and epigenetic regulators. The latter exhibits both activating and repressive effects on chromatin in keratinocytes via the ATP-dependent chromatin remodelers, histone demethylases, and genome organizers that promote terminal keratinocyte differentiation, and the DNA methyltransferases, histone deacetylases, and Polycomb components that stimulate proliferation of progenitor cells and inhibit premature activation of terminal differentiation-associated genes. In addition, microRNAs are involved in different processes between proliferation and differentiation during the program of epidermal development. Here, we bring together current knowledge of the mechanisms controlling gene expression during keratinocyte differentiation. An awareness of epigenetic mechanisms and their alterations in health and disease will help to bridge the gap between our current knowledge and potential applications for epigenetic regulators in clinical practice to pave the way for promising target therapies
NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: From cryopyrin function to targeted therapies
No full textThe NLRP3 inflammasome is one of the NOD-like receptor family members with the most functional characterization and acts as a key player in innate immune system, participating in several physiological processes including, among others, the modulation of the immune system response and the coordination of host defences. Activation of the inflammasome is a crucial signaling mechanism that promotes both an acute and a chronic inflammatory response, which can accelerate the production of pro-inflammatory cytokines, mainly Interleukin (IL)-1β and IL-18, leading to an exacerbated inflammatory network. Cryopyrin associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder, clinically characterized by cutaneous and systemic, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 gene are causative of signs and inflammatory symptoms in CAPS patients, in which an abnormal activation of the NLRP3 inflammasome, resulting in an inappropriate release of IL-1β and gasdermin-D-dependent pyroptosis, has been demonstrated both in in vitro and in ex vivo studies. During recent years, two new hereditary NLRP3-related disorders have been described, deafness autosomal dominant 34 (DFN34) and keratitis fugax hereditaria (KFH), with an exclusive cochlear- and anterior eye- restricted autoinflammation, respectively, and caused by mutations in NLRP3 gene, thus expanding the clinical and genetic spectrum of NLRP3-associated autoinflammatory diseases. Several crucial mechanisms involved in the control of activation and regulation of the NLRP3 inflammasome have been identified and researchers took advantage of this to develop novel target therapies with a significant improvement of clinical signs and symptoms of NLRP3-associated diseases. This review provides a broad overview of NLRP3 inflammasome biology with particular emphasis on CAPS, whose clinical, genetic, and therapeutic aspects will be explored in depth. The latest evidence on two “new” diseases, DFN34 and KFH, caused by mutations in NLRP3 is also described
Coexistence of steatocystoma multiplex and hidradenitis suppurativa : assessment of this unique association by means of ultrasonography and Color Doppler
No full textBackground: Steatocystoma multiplex (SM) is an uncommon skin disease manifesting as multiple sebum-containing cysts arising in pilosebaceous unit-rich body areas. Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory disease affecting the apocrine gland-bearing skin and presenting with both pseudocystic and inflammatory nodules, abscesses and fistulas. Considering that genetics has been reported to play a role in both entities, the albeit rare association between them suggests a shared genetic background. Although histology remains the gold standard for the diagnosis of SM, ultrasonography can be an useful diagnostic tool. This method is largely used in combination with Color Doppler for assessing disease severity in HS. Materials and Methods: We report three cases of coexisting SM and HS and describe the ultrasonography and Color Doppler features of the two entities. Results: SM lesions appeared on ultrasonography as hypoechoic nodules with well-defined hyperechoic borders and posterior acoustic enhancement, in the absence of Color Doppler signal. HS lesions had the ultrasonographic features of the fistulas, abscesses and pseudocystic nodules, some of which including hair fragments, with an intense Color Doppler signal within or around inflamed lesions. Conclusion: The combination of ultrasonography and Color Doppler proved to be a reliable instrument for differentiating between SM and HS lesions, particularly distinguishing HS pseudocystic nodules from true cysts of SM
Alti e veloci. La rapidità nella pallacanestro
No full textL’ipotesi di partenza di questo studio è stata quella di verificare se l’allenamento per uno sport nel quale la rapidità è molto importante, quale è la pallacanestro, possa modificare il risultato ottenibile in un test da campo comunemente impiegato per verificare la rapidità, ovvero la capacità di eseguire gesti corretti nel minor tempo possibile. Nello studio sono stati confrontati i risultati ottenuti nel test da un gruppo di ragazzi di età compresa tra i 14-16 anni praticanti pallacanestro a livello agonistico e un gruppo di coetanei sedentari. Sono stati considerati anche i dati antropometrici. I dati dei due gruppi sono stati confrontati con test t di Student ed è risultato che il livello prestativo dei soggetti sportivi è significativamente migliore di quelli sedentari (mentre i dati antropometrici sono sovrapponibili)
First-in-Man Surgical ERxtravascular-ICD Implanation:Suturing the defibrillation lead to the Heart Wall Post device-related endocarditis
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