654 research outputs found
On protocols for immediate implant placement and loading: A synthesis of relevant University of Genoa publications and their current clinical relevance
No full textInput-output decoupling for m-inputs m-outputs linear mechanical systems through interconnection
No full textThis paper deals with the input-output decoupling problem with asymptotic stability for a class of m-inputs m-outputs linear mechanical systems, through parallel connection with another mechanical system, called the controller. The paper gives a procedure for the design of a controller, which solves the above problem under some mild sufficient conditions, thus extending [1] where only 2-inputs 2-outputs linear mechanical systems were considered. © 2005 IEEE
On the first non vanishing local cohomology module
No full textLet M be a finitely generated module of depth n over a commutative local noetherian ring. We give an elementary description of the n-th local cohomology module of M. © 1981 Università degli Studi di Ferrara
The modulation of the ionic selectivity of the light-sensitive current in isolated rods of the tiger salamander.
No full text1. By using the method of Hodgkin, McNaughton & Nunn (1985) for rapidly changing the extracellular medium, we analysed the effect of the organic compound IBMX (3-isobutyl-1-methylxanthine) on the movement of divalent cations through the light-sensitive channels of isolated retinal rods of the tiger salamander. 2. When the rod is treated with 0.5 mM-IBMX it is possible to observe photocurrents larger than 50 pA carried by Ba2+, Sr2+, Ca2+, Mg2+ and Mn2+. Under these conditions Ca2+, Mg2+ and Mn2+ carry photocurrents of similar amplitude, while Ba2+ and Sr2+ usually carry larger photocurrents. 3. The movement of Mn2+ through the light-sensitive channel, which is hardly detected under normal conditions, can also be observed after treating the rod for a few seconds with a solution containing 35 mM[Na+]o and 10(-7) M[Ca2+]o. Under these conditions the photocurrent carried by Mn2+ is fully saturated in the presence of 1 mM-extracellular Mn2+. 4. When the rod is pre-treated with an extracellular solution containing 0.5 mM-IBMX the maximal photocurrent which can be carried by 10 mM [Ca2+]o increases from about 10 pA to approximately 200 pA. In these conditions the half-activation of the Ca2+ current is between 1 and 10 mM, that is 20-50 times higher than in normal conditions (Menini, Rispoli & Torre, 1988). 5. When the rod is pre-treated with an extracellular solution containing 0.5 mM-IBMX the half-activation of the photocurrent which can be carried by Mg2+, Ba2+ and Sr2+ is equivalent to or greater than 10 mM. In the absence of pre-treatment with IBMX the half-activation of the photocurrent carried by Mg2+, Ba2+ and Sr2+ is less than 5 mM. 6. We conclude that the light-sensitive channel can exist in at least two distinct open states. The selectivity of the channel in the first open state is as described in a previous paper (Menini et al. 1988). Mn2+, which is hardly permeable through the light-sensitive channel in the first open state, can move through the light-sensitive channel in the second open state. Ca2+, Mg2+, Ba2+ and Sr2+ permeate more freely through the light-sensitive channel in the second open state, probably because the electrostatic interactions between these ions and the channel are less strong
The blocking effect of l-cis-diltiazem on the light-sensitive current of isolated rods of the tiger salamander.
No full textThe effect of the organic compound l-cis-diltiazem on the light-sensitive current of isolated rods of the tiger salamander was analysed by rapidly changing the extracellular medium using the method of Hodgkin et al. (1985). Addition to the extracellular medium of small amounts of l-cis-diltiazem rapidly inhibits the photocurrent. Complete suppression of the current was observed with 1 m M l-cis-diltiazem. Half blockage of the photocurrent occurred with about 150 μM l-cis-diltiazem. The blocking effect of l-cis-diltiazem was enhanced by light and by a reduction of extracellular Na. A concentration of l-cis-diltiazem of 140 μM, which suppresses one third of the photocurrent, was able to completely suppress the photocurrent carried by Ba. It is suggested that l-cis-diltiazem blocks the light-sensitive channel, possibly competing with cyclic guanosine-3′-5′-monophosphate (cGMP) for an internal regulatory site
Between Baroque and (Neo)Gothic: Andrea Menini and the Renovation of Zagreb Cathedral around 1800
No full textNa temelju arhivskih izvora autor sagledava preinake u unutrašnjosti zagrebačke katedrale između 1799. i 1801. godine, koje su obuhvatile uklanjanje središnjeg dijela korske pregrade i premještanje oltara Sv. Križa. Radove, inicirane od strane biskupa Maksimilijana Vrhovca, vodio je kanonik Emerik Karlo Raffay, a izvodio ih je arhitekt Andrea Menini sa suradnicima. Rekonstrukcija izgubljenih elemenata otkriva rane oblike neogotičkoga izraza.Based on archival sources, the author examines the alterations made to the interior of Zagreb Cathedral between 1799 and 1801, which included the removal of the central section of the choir screen and the relocation of the Altar of the Holy Cross. The works, initiated by Bishop Maksimilijan Vrhovac, were supervised by Canon Emerik Karlo Raffay and carried out by architect Andrea Menini and his associates. The reconstruction of the lost elements reveals early forms of Neo-Gothic expression
Some Remarks on Connected Coalgebras
No full textIn this paper we introduce the notions of connected, 0-connected and strictly graded coalgebra in the framework of an abelian monoidal category M and we investigate the relations between these concepts. We recover several results, involving these notions, which are well known in the case when M is the category of vector spaces over a field K. In particular we characterize when a 0-connected graded bialgebra is a bialgebra of type one
Carbon fibre versus metal framework in full-arch immediate loading rehabilitations of the maxilla - a cohort clinical study
No full textFrameworks made of carbon fibre-reinforced composites (CFRC) seem to be a viable alternative to traditional metal frameworks in implant prosthodontics. CFRC provide stiffness, rigidity and optimal biocompatibility. The aim of the present prospective study was to compare carbon fibre frameworks versus metal frameworks used to rigidly splint implants in full-arch immediate loading rehabilitations. Forty-two patients (test group) were rehabilitated with full-arch immediate loading rehabilitations of the upper jaw (total: 170 implants) following the Columbus Bridge Protocol with four to six implants with distal tilted implants. All patients were treated with resin screw-retained full-arch prostheses endowed with carbon fibre frameworks. The mean follow-up was 22 months (range: 18â24). Differences in the absolute change of bone resorption over time between the two implant sides (mesial and distal) were assessed performing a MannâWhitney U-test. The outcomes were statistically compared with those of patients rehabilitated following the same protocol but using metal frameworks (control group: 34 patients with 163 implants â data reported in Tealdo, Menini, Bevilacqua, Pera, Pesce, Signori, Pera, Int J Prosthodont, 27, 2014, 207). Ten implants failed in the control group (6·1%); none failed in the test group (P = 0·002). A statistically significant difference in the absolute change of bone resorption around the implants was found between the two groups (P = 0·004), with greater mean peri-implant bone resorption in the control group (1 mm) compared to the test group (0·8 mm). Carbon fibre frameworks may be considered as a viable alternative to the metal ones and showed less marginal bone loss around implants and a greater implant survival rate during the observation period
TMEM16B induces chloride currents activated by calcium in mammalian cells
No full textCa(2+)-activated Cl(-) channels play important physiological roles in various cell types, but their molecular identity is still unclear. Recently, members of the protein family named transmembrane 16 (TMEM16) have been suggested to function as Ca(2+)-activated Cl(-) channels. Here, we report the functional properties of mouse TMEM16B (mTMEM16B) expressed in human embryonic kidney (HEK) 293T cells, measured both in the whole-cell configuration and in inside-out excised patches. In whole cell, a current induced by mTMEM16B was activated by intracellular Ca(2+) diffusing from the patch pipette, released from intracellular stores through activation of a G-protein-coupled receptor, or photoreleased from caged Ca(2+) inside the cell. In inside-out membrane patches, a current was rapidly activated by bath application of controlled Ca(2+) concentrations, indicating that mTMEM16B is directly gated by Ca(2+). Both in the whole-cell and in the inside-out configurations, the Ca(2+)-induced current was anion selective, blocked by the Cl(-) channel blocker niflumic acid, and displayed a Ca(2+)-dependent rectification. In inside-out patches, Ca(2+) concentration for half-maximal current activation decreased from 4.9 microM at -50 mV to 3.3 microM at +50 mV, while the Hill coefficient was >2. In inside-out patches, currents showed a reversible current decrease at -50 mV in the presence of a constant high Ca(2+) concentration and, moreover, an irreversible rundown, not observed in whole-cell recordings, indicating that some unknown modulator was lost upon patch excision. Our results demonstrate that mTMEM16B functions as a Ca(2+)-activated Cl(-) channel when expressed in HEK 293T cells
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