720 research outputs found
Study of radiation damage and substrate resistivity effects from beam test of silicon microstrip detectors using LHC readout electronics
No full textWe present the beam test results of single-sided silicon microstrip detectors, with different substrate resistivities. The effects of radiation damage are studied for a detector irradiated to a fluence of 2.4 x 10(14) n/cm(2). The detectors are read out with the APV6 chip, which is compatible with the 40 MHz LHC clock, The performance of different detectors and readout modes are studied in terms of signal-to-noise ratio and efficiency. (C) 2002 Elsevier Science B.V. All rights reserved
Drug injection in jugular veins: a new risk factor for vascular diseases in HIV-infected patients?
No full textComparison of three enzyme-linked immunosorbent assays suitable for the detection of antibodies to rotaviruses in epidemiological studies
No full textFattori aspecifici e placebo in psicofarmacoterapia
No full textFattori aspecifici e placebo in psicofarmacoterapi
Psychoeducatlon in binge eating disorder: Factors predicting efficacy
No full textObjective: The aim of this study is to identify the factors that influence the effectiveness of group psychoeducation, defined as absence of binge eating, at the end and one year after therapy, in subjects with binge eating disorder (BED). Also was evaluated the correlation between binge eating and obesity, assessing which factors may be predictors for satisfyingly weight loss. Methods: A total of 26 patients were included in the study (Table I). Subjects who continued binge eating at the end of the therapy (t1) were defined as non-responsive patients (NR); those who continued binge eating one year after therapy (t2) were defined as non-abstinent patients (NA) (Fig. 1). The predictor factors were divided into clinical and psychometric variables. The following clinical data were considered: years of dieting and binge eating, body mass index (BMI) and the frequency of binge eating at the beginning of therapy (t0). The psychometric data analysed were: eating aptitude and behaviour (EDI-2), alexithymia (TAS-20), family support (FA), anxiety and depression (HADS). These data were estimated at t0 and t1. Results: The NR (n = 6; 23.1%) were attributed higher scores in the anxiety subclassification (HADS) at t0. The NA (n = 7; 26.9%) presented a higher rate and a higher number of years of binge eating, furthermore they had a lower level of family support at t0. No patients had a satisfactory weight loss at t1; 19.2% of the patients lost weight at t2 (Table II). Conclusions: The present study confirms, as observed in other studies, that clinical parameters, like the rate and number of years of binge eating at the beginning of therapy, are predictor factors for maintenance of effectiveness one year after treatment. Furthermore, anxiety before therapy results in a lower response to treatment and poor family support is associated with inadequate results of maintenance one year after therapy. No association between weight loss and disappearance of binge eating was observed. Thus, these parameters may be used by the clinician to identify a population of patients who need another therapeutic approach, with integrated and long interventions
Letter: chronic hepatitis C genotype 3 infection - still a hurdle toward a direct-acting anti-viral-induced HCV cure?
No full textLetter: chronic hepatitis C genotype 3
infection – still a hurdle toward a
direct-acting anti-viral-induced HCV cur
Indagine sulla presenza di positività al test TPHA in una popolazione di soggetti anti-HIV sieropositivi
No full textApparent selection against trasmission of zidovudine resistant human immunodeficiency virus type 1 variants
No full text
Neutralizing antibodies to recombinant alpha-interferon and response to therapy in chronic hepatitis C virus infection
No full textForty-seven patients with chronic hepatitis C were treated with recombinant interferon alpha-2a (rIFNalpha2a) given subcutaneously in a standard dose of 3 MU thrice weekly for 12 months. Stored baseline sera and monthly samples during treatment were assayed for anti-interferon neutralizing antibodies using the antiviral neutralization bioassay against 5 IU of rIFNalpha2a. During therapy, 15 of 47 patients (31.9%) developed detectable levels of neutralizing antibodies within 2-8 months after starting treatment. After 12 months of therapy, 26 of 32 antibody-negative patients (81.3%) showed normalization or marked reduction of ALT levels compared to 4 of 15 (26.6%) who developed anti-IFN neutralizing antibodies (p=0.0009). Four patients demonstrated antiviral response during treatment even in the presence of low levels or late occurrence of neutralizing antibodies. Six of the seven patients who had disease reactivation after an initial response developed high titers of neutralizing antibodies. Our results suggest that reactivation of chronic hepatitis C before completion of therapy seems to be an obvious consequence of anti-IFN neutralizing antibody formation
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