1,154 research outputs found
Il Centri culturali delle donne
No full textPresentazione di iniziative culturali di donne (comunità Diotima, Libreria delle donne di Milano, Ipazia ecc.), e loro formativita
In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cells
No full textThe effect of oleanolic acid on the growth of human immunodeficiency virus-1 (HIV-1) in cultures of human peripheral mononuclear cells (PBMC) and of monocyte/macrophages (M/M) is described. The inhibitory activity was also evaluated on PBMC obtained from HIV-1 infected patients. Oleanolic acid inhibited the HIV-1 replication in all the cellular systems used. As regards the mechanism of action, oleanolic acid inhibited the HIV-1 protease activity in vitr
Diagnosi immunologica dell'infezione da M. tuberculosis in pazienti pediatrici e HIV positivi: Quantiferon (QF)-TB Gold
No full textAnti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain
No full textTreatment with drugs designed to inhibit the HIV protease ameliorates immune functions in AIDS patients, reducing cell deletion by apoptosis even in the absence of inhibition of viral spread. This suggests that they interact with the intrinsic apoptotic signaling. We found that caspases, the main executioner of the apoptotic process, are not directly inhibited. In search for the mechanism responsible for their anti-apoptotic effect, we have found that indinavir and ritonavir are able to inhibit apoptosis only in those cell systems where apoptosis involves the activation of calpains. They directly inhibit a calpain-like activity expressed in lysates from apoptotic cells, to the same extent as commercially available calpain inhibitor 1. In in vitro assays with purified calpains, indinavir and ritonavir strongly inhibit m-calpain, and moderately mu-calpain. These results have great therapeutic implications, going beyond AIDS treatment, since many degenerative disorders involve abnormal calpain activation, indicating calpain as an ideal pharmacological target. Indinavir and ritonavir, potent m-calpain inhibitors, largely used since several years on humans without important negative side effects, may become powerful tools against those pathologies
Test immunologici nello screening di infezione da M. tuberculosis in pazienti hiv positivi
No full text
Utilità clinica del QUANTIFERON –TB GOLD nel monitoraggio terapeutico in corso di tubercolosi
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