589 research outputs found
L’immagine dell’oceano tra epica e Kavya: leggendo il VI libro del Ramayana (G.)
No full textThis paper mainly focuses on the typology of sea images spotted out in the Yuddhakanda of Ramayana. It aims to outline some sea imagery features in Indian pre-kāvya literature by the way of comparison with analogous images quoted from the Mahabharata and from some Kavya works. The war context is prevailing in the selected epic book. Therefore the ocean is quite regularly a second term of comparison for single warriors or for armies
Endosomal receptor trafficking and signal transduction in Schwann cells: regulation of the Nrg1-induced PI3-kinase pathway
No full textNeuregulin1-ErbB signaling is important for various functions during Schwann cell development and myelination. Activation of the ErbB receptors also triggers myelin breakdown in mature myelinating Schwann cells. The mechanism by which the activated ErbB receptor complex elicits multiple biological functions in Schwann cells is unclear. In Charcot-Marie-Tooth (CMT) disease - the most common demyelinating neuropathy in the peripheral nervous system - many proteins involved in regulating intracellular vesicular trafficking and sorting through the endocytic pathway are found mutated. Endocytic pathways are also strongly implicated in the regulation of signal transduction by cell surface receptors. It is possible that aberrant regulation of the ErbB receptors and downstream signal activation by the impaired endocytic components contribute to the disease manifestation. The function of ErbB receptor trafficking and signal modulation in Schwann cells is largely unknown. We hypothesized that Nrg1-induced ErbB2 and ErbB3 receptor trafficking can differentially regulate signaling by spatially and temporally localizing receptors in different endocytic compartments. In this study, we show that following treatment with soluble Nrg1, internalized ErbB receptors are sorted into the late endosome/lysosome for degradation or transported to the recycling endosome and reappear on the cell surface. ErbB receptor recycling is also regulated by Nrg1 dose. Inhibition of receptor endocytosis by impairing dynamin activity blocked the Nrg1-induced Akt activation and abrogated the pro-myelinating effect in co-cultures. Interestingly, allowing receptor endocytosis but inhibiting the subsequent recycling from the early endosome enhanced Akt activation, indicating the importance of the early endosomal signaling for the Nrg1-induced Akt activity. Supporting this, sub-cellular fractionation showed that active Akt was enriched in the endosomal fraction in Schwann cells. We also investigated the mechanism by which membrane-bound Nrg1 Type III regulates ErbB receptor trafficking in Schwann cells. Binding of the axonal Nrg1 induced both ErbB2 and ErbB3 downregulation indicating receptor internalization. The membrane-bound Nrg1 Type III was also internalized into the Schwann cells, appearing in Rab5-positive early endosomes. The Nrg1-induced Akt activation, which is necessary for myelination was abrogated when receptor endocytosis in Schwann cells was blocked. Our results show that endocytic trafficking is important for the pro-myelinating function of Nrg1. The results also suggest that impaired endocytic pathways may contribute to the development of demyelinating neuropathy by resulting in aberrant regulation of the Nrg1-ErbB signaling in Schwann cells.Ph. D.Includes bibliographical referencesIncludes vitaby Kavya Redd
sj-docx-1-han-10.1177_15589447211064365 – Supplemental material for Prescription Opioids and Patient-Reported Outcomes and Satisfaction After Carpal Tunnel Release Surgery
No full textSupplemental material, sj-docx-1-han-10.1177_15589447211064365 for Prescription Opioids and Patient-Reported Outcomes and Satisfaction After Carpal Tunnel Release Surgery by Pragna N. Shetty, Kavya K. Sanghavi, Mihriye Mete and Aviram M. Giladi in HAND</p
sj-docx-2-han-10.1177_15589447211064365 – Supplemental material for Prescription Opioids and Patient-Reported Outcomes and Satisfaction After Carpal Tunnel Release Surgery
No full textSupplemental material, sj-docx-2-han-10.1177_15589447211064365 for Prescription Opioids and Patient-Reported Outcomes and Satisfaction After Carpal Tunnel Release Surgery by Pragna N. Shetty, Kavya K. Sanghavi, Mihriye Mete and Aviram M. Giladi in HAND</p
Buddhaghosa
No full textThis entriy is about Buddhaghosa or Buddhaghosacarya, a poet of unknown date known for being the author of the Padyacudamani (The Crest-Jewel of Verses), a Sanskrit mahakavya (great kavya) or sargabandha (canto composition) poem
sj-docx-1-han-10.1177_15589447221077367 – Supplemental material for Billing and Utilization Trends for Hand Surgery Indicate Worsening Barriers to Accessing Care
No full textSupplemental material, sj-docx-1-han-10.1177_15589447221077367 for Billing and Utilization Trends for Hand Surgery Indicate Worsening Barriers to Accessing Care by Jung Ho Gong, Chao Long, Adam E. M. Eltorai, Kavya K. Sanghavi and Aviram M. Giladi in HAND</p
sj-docx-2-han-10.1177_15589447221077367 – Supplemental material for Billing and Utilization Trends for Hand Surgery Indicate Worsening Barriers to Accessing Care
No full textSupplemental material, sj-docx-2-han-10.1177_15589447221077367 for Billing and Utilization Trends for Hand Surgery Indicate Worsening Barriers to Accessing Care by Jung Ho Gong, Chao Long, Adam E. M. Eltorai, Kavya K. Sanghavi and Aviram M. Giladi in HAND</p
Speculative execution framework to make Linux services fault tolerant
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 47-48).Cabala is a speculative execution framework that enables server programs in Linux to be fault tolerant. The errors it targets are run-time errors that are due to program bugs, and which cause program exit; in particular, it provides resilience to errors triggered by requests. The Cabala framework is implemented as a user-space library, and enforces per-request checkpoint/rollback semantics to provide fault-tolerance. It provides facilities for checkpointing the state of the server program just before request processing starts, executing the processing in an isolated environment, detecting tolerated run-time errors before they cause program exit, and committing or discarding the modifications made during processing. Cabala addresses the fault tolerance needs of server programs in the context of supported errors. It enables the services provided by a server program to be highly available and ensures that a program which is correct and satisfies Cabala's requirements remains correct despite tolerated errors; it also ensures that the system's state remains consistent. In addition, Cabala is easy to use; the only changes required to the server program's source code are the inclusion of the Cabala library and the addition of three library function calls. Cabala was evaluated with two Linux server programs, the Apache2 web server and the DHCP4 DHCP server; it detected the tolerated errors and correctly recovered the server programs in both cases.by Kavya Joshi.M. Eng
sj-docx-1-han-10.1177_15589447221141482 – Supplemental material for Pain Control and Satisfaction With Peripheral Nerve Blocks for Upper Extremity Surgery
No full textSupplemental material, sj-docx-1-han-10.1177_15589447221141482 for Pain Control and Satisfaction With Peripheral Nerve Blocks for Upper Extremity Surgery by Caroline M. Wu, Cyril S. Gary, Kristin E. Karim, Kavya K. Sanghavi, Michael S. Murphy, J. Todd Hobelmann and Aviram M. Giladi in HAND</p
Concrete particle characterization using impedance cytometry
No full textWe demonstrate a novel method to detect and characterize the size and number of Wollastonite particles using microfluidic impedance cytometry. The fabricated device which consists of gold electrodes micro-fabricated in a microchannel is capable of detecting particles >1 micron. Particle characterization is often carried out across a wide range of industries and is a critical parameter in the manufacture of various products to help improve the characteristics, performance or quality of powders or particles. There are a number of commercially available particle characterization techniques like laser diffraction, dynamic light scattering, electrophoretic light scattering, automated imaging, sedimentation etc that can be used to measure particulate samples and each has its relative strengths and limitations-there is no universally applicable technique for all samples. Our approach uses electrical impedance spectroscopy which measures the change in impedance as the particles in suspension pass through the sensor. It is a highly precise, low cost alternative for particle size characterization with a smaller footprint offering quick analysis time and is suitable for relatively broad range of particle sizes.M.S.Includes bibliographical referencesby Kavya Vasudevamurth
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