13,205 research outputs found
Rationally designed Magnetic Particles enable Capturing and Detection of Bacterial Pathogens
No full textIn this work we highlight magnetic blood purification as possible therapy for blood stream infections [1-2], where circulating pathogens are at first removed from the bodily fluid and subsequently recovered and analyzed. (Fig. 1) This process would result in an immediate therapeutic benefit for the patient, while also considerably shortening the diagnosis process, a critical step which heavily affects the final outcome of the treatment. Finally, the use of a newly developed human IgG1 monoclonal antibody against poly-N-acetylglucosamine (PNAG) as targeting moiety extends this therapy to the majority of the pathogens responsible for the most frequent nosocomial infections. We show an experimental proof-of-concept study along with an optimization of carrier-pathogen interactions based on a mathematical model and an investigations on the process safety [3].
[1] I. K. Herrmann, M. Urner, F. M. Koehler, M. Hasler, B. Roth-Z’Graggen, R. N. Grass, U. Ziegler, B. Beck-Schimmer, and W. J. Stark, Small, 2010, 6, 1388
[2] I. K. Herrmann , M. Urner, S. Graf , C. M. Schumacher , B. Roth-Z’graggen , M. Hasler , W. J. Stark , and B. Beck-Schimmer, Adv. Healthcare Mater., 2013, 2, 829–835
[3] M. Lattuada, Q. Ren, F. Zuber, M. Galli, N. Bohmer, A. Wichser, S. Bertazzo, G. B. Pier and I. K. Herrmann, J. Mater Chem. B, under review
Rosa moschata J. Herrmann
No full text4. R. moschata J. Herrmann, Hiss. Rosa 15 (1762). Vigorous evergreen climber up to 12 m. Prickles sparse, stout, curved. Leaflets 5-7, 25-55 x 20-30 mm, ovate to elliptical, usually acute, serrate, usually pubescent, greyish-green beneath. Inflorescence many-flowered. Pedicels slightly pubescent and glandular. Sepals lanceolate, with a setiform apical appendage, more or less grey-pubescent, the outer with 2-4 lobes. Petals 10-15 mm, creamy-white. Stylar column hairy. Fruit 8-10 mm, ovoid. Cultivated for ornament, mainly in S. & W. Europe; naturalized in the Mediterranean region. [Cr Ga Gr Hs Si.] (Himalaya, Iran.)Published as part of I. Klášterský, 1968, 10. Rosa L., pp. 35-42 in Flora Europaea, Volume 2, Rosaceae to Umbelliferae, Cambrdige :Cambridge University Press on page 27, DOI: 10.5281/zenodo.4706
Child Welfare Practice : A Conversation About Reality
No full textBy Kenneth J. Herrmann, College at Brockport faculty member.
The author\u27s fifty years of practice in social work and child welfare have resulted in this examination and critique of America\u27s treatment of childhood. This advances a radical approach to ensuring the needs of children, an approach based in social justice and human rights.https://digitalcommons.brockport.edu/bookshelf/1345/thumbnail.jp
Natriuretic peptides or psychometric tests? Prognostic markers in congestive heart failure
No full textRosa virginiana J. Herrmann
No full text13. R. virginiana J. Herrmann, Diss. Rosa 19 (1762). Stems up to 2 m, with few or no suckers; bark bluish-green, becoming reddish-brown. Prickles hooked, curved or absent. Leaflets 5-9, 20-60 x 12-25 mm, elliptical to elliptic-obovate, often cuneate at base, acute, serrate, dull green above, glabrous or sparsely hairy beneath; teeth eglandular. Flowers 2-8. Bracts much shorter than the pedicels. Pedicels glandular-hispid. Sepals patent and deciduous after anthesis, glandular-hispid on the back. Petals 15-25(-30) mm, pink or white. Styles lanate. Fruit 10-15 mm, ovoid-globose to globose, glandular-hispid. Cultivated for ornament and locally naturalized. [Au Br Ga.] (E. North America.) Sect, rosa (Sect. Gallicanae DC.). Erect, usually low shrubs. Rhizome long. Stems usually with hooked prickles mixed with acicles. Outer sepals usually pinnatifid, deflexed and deciduous after anthesis. Disc wide, with a narrow orifice. Carpels sessile. Styles free.Published as part of I. Klášterský, 1968, 10. Rosa L., pp. 35-42 in Flora Europaea, Volume 2, Rosaceae to Umbelliferae, Cambrdige :Cambridge University Press on page 28, DOI: 10.5281/zenodo.4706
A new heuristic for the total tardiness problem with parallel machines
No full textBiskup D, Herrmann J. A new heuristic for the total tardiness problem with parallel machines. Discussion paper / Fakultät für Wirtschaftswissenschaften, Universität Bielefeld. Bielefeld: Universität Bielefeld; 2007.Scheduling jobs against due dates is one of the most important and best examined objectives in scheduling theory and practice. In this paper the parallel machine version of the well-known total tardiness problem is considered. The objective is to minimize the total tardiness of the jobs, while for all jobs an individual due date is given. The single machine version has been proven to be NP-hard, hence it is unlikely to find polynomially bounded optimization algorithms. Consequently, we concentrate on developing an efficient heuristic. Our extensive computational results confirm that our new heuristic is capable to deliver near optimal results
Neue Ängste Jugendlicher
No full textMansel J. Neue Ängste Jugendlicher. In: Mansel J, Schweins W, Ulbrich-Herrmann M, eds. Zukunftsperspektiven junger Menschen. Wirtschaftliche und soziale Entwicklungen als Herausforderung und Bedrohung. Weinheim/München: Juventa; 2001: 72-88
Zukunftsperspektiven Jugendlicher: wirtschaftliche und soziale Entwicklungen als Herausforderung und Bedrohung für die Lebensplanung
No full textMansel J, Schweins W, Ulbrich-Herrmann M, eds. Zukunftsperspektiven Jugendlicher: wirtschaftliche und soziale Entwicklungen als Herausforderung und Bedrohung für die Lebensplanung. Jugendforschung. Weinheim, München: Juventa; 2001
Neural networks approach to clustering of activity in fMRI data
No full textClusters of correlated activity in functional magnetic resonance imaging data can identify regions of interest and indicate interacting brain areas. Because the extraction of clusters is computationally complex, we apply an approximative method which is based on artificial neural networks. It allows one to find clusters of various degrees of connectivity ranging between the two extreme cases of cliques and connectivity components. We propose a criterion which allows to evaluate the relevance of such structures based on the robustness with respect to parameter variations. Exploiting the intracluster correlations, we can show that regions of substantial correlation with an external stimulus can be unambiguously separated from other activity
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