78 research outputs found
La moderna Anestesia Generale:cenni storici e descrizione delle tecniche di applicazione più corrente
No full textAll'inizio sono brevemente elencati i primi passi della moderna anestesia in Italia e si parla poi del dualismo tra scuola Anglo -Americana e scuola Europea per le diverse tendenze nella scelta dei farmaci anestetici.Vengono poi esposte in maniera sintetica, le metodiche usate in epoca attuale
Modificazioni respiratorie indotte nell'uomo da dosi equipotenti di tre diverse Benzodiazepine
No full textDopo un breve cenno alle più moderne teorie relative al meccanismo di azione delle benzodiazepine,vengono esposti i risultati ottenuti in trenta individui di ambo i sessi, tra i 18 e i 50 anni, somministrando in ciascun gruppo di 10 soggetti diazepam,flunitrazepam e midazolam per via endovenosa
Il naloxone nell'overdose da etanolo successiva ad alcolizzazione di metastasi epatiche
No full textGli aurtori descrivono un caso di coma prolungato successivo ad intossicazione da etanolo dopo alcolizzazione di una metastasi epatica trattato con successo con naloxone
A screening of antineoplastic drugs for acute myeloid leukemia reveals contrasting immunogenic effects of etoposide and fludarabine
No full textBackground: Recent evidence demonstrated that the treatment of acute myeloid leukemia (AML) cells with daunorubicin (DNR) but not cytarabine (Ara-C) results in immunogenic cell death (ICD). In the clinical setting, chemotherapy including anthracyclines and Ara-C remains a gold standard for AML treatment. In the last decade, etoposide (Eto) and fludarabine (Flu) have been added to the standard treatment for AML to potentiate its therapeutic effect and have been tested in many trials. Very little data are available about the ability of these drugs to induce ICD. Methods: AML cells were treated with all four drugs. Calreticulin and heat shock protein 70/90 translocation, non-histone chromatin-binding protein high mobility group box 1 and adenosine triphosphate release were evaluated. The treated cells were pulsed into dendritic cells (DCs) and used for in vitro immunological tests. Results: Flu and Ara-C had no capacity to induce ICD-related events. Interestingly, Eto was comparable to DNR in inducing all ICD events, resulting in DC maturation. Moreover, Flu was significantly more potent in inducing suppressive T regulatory cells compared to other drugs. Conclusions: Our results indicate a novel and until now poorly investigated feature of antineoplastic drugs commonly used for AML treatment, based on their different immunogenic potential
The use of di-hydroxypropylphenol (Propophol) in endoscopic procedures
No full textThe authors illustrate different endoscopic procedures that may require anaesthesiological assistance through analgo-sedation procedures. Analgo- sedation is useful to the patient and to the endoscopist that can carry out the exam more rapidly and in optimal conditions. The technique employed consists in the administration of propophol, starting with an initial bolus of the drug followed by a continuous perfusion to maintain the hypnotic state. Monitoring of cardiovascular and respiratory parameters shows a great reliability of the drug and effectiveness of the method
Midazolam e Remifentanil in infusione continua negli interventi di adenomectomia trans-vescicale
No full textLe peculiari caratteristiche farmacocinetiche e farmacodinamiche di composti a breve durata d'azione come il midazolam ed il remifentanil producono come risultato il raggiungimento di un adeguato piano di anestesia,il suo stabile mantenimento ed un rapido recupero al termine dell'atto chirurgico
Variation of acid-base balance, glycemia, electrolytes and ETCO2 after fast i.v. infusion of 5% fructose and/or glucose
No full textIntraoperative fluid infusion has precise goals and the rapid infusion of some solutions can induce important modifications of homeostatic parameters, which must be known. Rapid infusion of fructose and glucose 5% solutions has been carried out and modifications of acid-base balance, glycemia, serum electrolytes, ETCO2 have been registered. The administration of fructose 5% determines a mixed acidosis while the administration of glucose does not cause this phenomenon; the administration of both carbohydrates reduces serum chloride and sodium, while serum potassium rises only after fructose infusion and glycemia only after glucose infusion. All the variations described reach significant levels
Analgesia and sedation with propofol-NSAIDs for day-hospital extracorporeal shock wave lithotripsy (ESWL)
No full textAfter a brief history of extracorporeal therapies for calculosis, with particular attention devoluted to renal calculosis and to the instruments that consent these therapeutic alternatives, the authors report the results obtained with a technique of analgesia and sedation. The drugs employed are two NSAIDs, ketoprophene and ketorolac tromethamine associated with propofol. The main advantages consist in the limited cardiovascular and respiratory depression, typical of the first minutes of administration of propofol and the rapid return of a complete functional autonomy in relative brief time intervals, with possibility of dismissing the patient after 4 hours from the end of treatment
Variazioni della irrorazione Sanguigna Periferica valutate mediante flussimetria "Strain-Gage" in corso di Anestesia Endovenosa Bilanciata
No full textDopo aver fatto un breve richiamo all'importanza del normale circolo capillare durante l'anestesia e l'intervento chirurgico,vengono esposti i risultati ottenuti esplorando il comportamento del pletismogramma " straingage" durante interventi di varia chirurgia di elezione in corso di anestesia endovenosa bilanciata
Side effects and complication of Port-A-Cath.
No full textCentral venous catheter techniques find at present use for administering of NPT, for the drug injection ( especially chemiotherapeutic drugs) because of the possible damage of a few substances when perfused in a peripheral way. At present port-a-cath find their most extensive use: these are systems which can be set up and tolerated for many months. For the access to subclavian vein must be necessary put in supine decubitus, with light Trendelenburg position, with the opposite arm along the body and the head turned on the opposite side. In this way the clavicle is in perpendicular position with regard to the sternal handlebar, except for patient affected with bpco, kypho-scoliosis, scapular-homeral arthrosis. In these patients the clavicle can put on a particular course, oblique and upper as to the sternal articular face. So there is a serious obstacle to the passage to the metal needle under the clavicle. KEY WORDS: Chemiotherapy, CVC, NPT, Port-a-Cath
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