769 research outputs found
Digging In: Which Dementia Symptoms Are Most Burdensome to Caregivers?
No full textAbstract
Date Presented 3/31/2017
Despite much reporting on the association between neuropsychiatric symptoms (NPS) of dementia and caregiver burden, little preparatory work has informed whether the type of NPS influences burden level. This exploratory factor analysis with 569 dyads reports clinically meaningful findings.
Primary Author and Speaker: Paul Arthur
Contributing Authors: John Kairalla, William C. Mann, Laura Gitlin</jats:p
Sixties Author to Appear for UD\u27s Distinguished Speaker Series
No full textNews release announces that Todd Gitlin, author of the acclaimed book The Sixties: Years of Hope, Days of Rage and director of mass communication at the University of California at Berkeley, will appear at the University of Dayton as part of the Distinguished Speaker Series
Economically Disadvantaged Youths Say \u27No\u27 to Drugs as Part of National Youth Sports Program at UD; \u27Sixties\u27 Author to Appear for UD\u27s Distinguished Speaker Series
No full textMedia tip sheet: A drug education specialist will speak as an extension of the National Youth Sports Program; author Todd Gitlin will give a lecture as part of the Distinguished Speaker Series
Results of indirect and mixed treatment comparison of fracture efficacy for osteoporosis treatments: a meta-analysis
No full textSummaryNetwork meta-analysis techniques (meta-analysis, adjusted indirect comparison, and mixed treatment comparison [MTC]) allow for treatment comparisons in the absence of head-to-head trials. In this study, conditional estimates of relative treatment efficacy derived through these techniques show important differences in the fracture risk reduction profiles of marketed pharmacologic therapies for postmenopausal osteoporosis.IntroductionThis study illustrates how network meta-analysis techniques (meta-analysis, adjusted indirect comparison, and MTC) can provide comparisons of the relative efficacy of postmenopausal osteoporosis therapies in the absence of comprehensive head-to-head trials.MethodsSource articles were identified in MEDLINE; EMBASE; Cochrane Central Register of Controlled Trials (CENTRAL) via Wiley Interscience; and Cumulative Index to Nursing and Allied Health Literature (CINAHL) between April 28, 2009 and November 4, 2009. Two reviewers identified English-language articles reporting randomized controlled trials (RCTs) with on-label dosing of marketed osteoporosis agents and fracture endpoints. Trial design, population characteristics, intervention and comparator, fracture outcomes, and adverse events were abstracted for analysis. Primary analyses included data from RCTs with fracture endpoints. Sensitivity analyses also included studies with fractures reported through adverse event reports. Meta-analysis compared fracture outcomes for pharmacological therapies vs. placebo (fixed and random effects models); adjusted indirect comparisons and MTC assessed fracture risk in postmenopausal women treated with denosumab vs. other agents.ResultsUsing data from 34 studies, random effects meta-analysis showed that all agents except etidronate significantly reduced the risk of new vertebral fractures compared with placebo; denosumab, risedronate, and zoledronic acid significantly reduced the risk for nonvertebral and hip fracture, while alendronate, strontium ranelate, and teriparatide significantly reduced the risk for nonvertebral fractures. MTC showed denosumab to be more effective than strontium ranelate, raloxifene, alendronate, and risedronate in preventing new vertebral fractures.ConclusionsThe conditional estimates of relative treatment efficacy indicate that there are important differences in fracture risk reduction profiles for marketed pharmacological therapies for postmenopausal osteoporosis
Supplemental Material - Economic Analysis of the Tailored Activity Program: A Nonpharmacological Approach to Improve Quality of Life in People Living With Dementia and their Caregivers
No full textSupplemental Material for Economic Analysis of the Tailored Activity Program: A Nonpharmacological Approach to Improve Quality of Life in People Living With Dementia and their Caregivers by Laura T. Pizzi, Katherine M. Prioli, Eric Jutkowitz, Catherine V. Piersol, Constantine G. Lyketsos, Ilze Abersone, Katherine A. Marx, and Laura N. Gitlin in Journal of Applied Gerontology</p
Supplemental Material - Evidence Map of Non-Pharmacological Dementia Care Partner Interventions Implemented in the US: Gaps and Impact Opportunities
No full textSupplemental Material for Evidence Map of Non-Pharmacological Dementia Care Partner Interventions Implemented in the US: Gaps and Impact Opportunities by Zachary G. Baker, Maria Dellapina, Allison M. Gustavson, Justine S. Sefcik, Sokha Koeuth, Joseph E. Gaugler, Kimberly Van Haitsma, and Laura N. Gitlin in Journal of Applied Gerontology</p
Patterns of bovine plasma luteinizing hormone and pituitary luteinizing hormone response to gonadotropin-releasing hormone during gestation and early postpartum
No full textDue to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Bibliography: leaves 34-38.Not availabl
T follicular helper cell dynamics in germinal centers
No full textT follicular helper (T(FH)) cells are a specialized subset of effector T cells that provide help to and thereby select high-affinity B cells in germinal centers (GCs). To examine the dynamic behavior of T(FH) cells in GCs in mice, we used two-photon microscopy in combination with a photoactivatable fluorescent reporter. Unlike GC B cells, which are clonally restricted, T(FH) cells distributed among all GCs in lymph nodes and continually emigrated into the follicle and neighboring GCs. Moreover, newly activated T(FH) cells invaded preexisting GCs, where they contributed to B cell selection and plasmablast differentiation. Our data suggest that the dynamic exchange of T(FH) cells between GCs ensures maximal diversification of T cell help and that their ability to enter ongoing GCs accommodates antigenic variation during the immune response
Interrupting the institutional, narrative on teacher training: The potential of school-based teacher education
No full textCurrently, teacher education is at the crossroads. Stimulated by a plethora of government reports and inquiries there are cries for reform, restructuring and change. As teacher educators we have grappled with the complexities, contradictions and tensions emanating from these reform efforts on two fronts. At the institutional level, we have suffered the alienating consequences of restructuring through budget cuts, staff sackings, 'efficiencies', and the casualisation of academic work. At the collegial level, we have struggled to make sense of the "teacher training business" and what it means to be a teacher and teacher educator in this increasingly hostile environment (Bullough & Gitlin, 1994; Knight, Bartlett & McWilliam, 1993)
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