71 research outputs found
Sister M. Caroline Ann Gimpl, B.A., M.A., The Correspondant and the Founding of the French Third Republic, 1959
No full textMolette Charles. Sister M. Caroline Ann Gimpl, B.A., M.A., The Correspondant and the Founding of the French Third Republic, 1959. In: Revue des Sciences Religieuses, tome 35, fascicule 2, 1961. pp. 207-213
Skeletal muscle remodeling in response to alpine skiing training in older individuals
No full textThis study investigated whether regular alpine skiing could reverse sarcopenia and muscle weakness in older individuals. Twenty-two older men and women (67 ± 2 yr) underwent 12 weeks of recreational skiing, 2-3 times a week, each session lasting ~3.5 hours. An age-matched, inactive group (n = 20, 67 ± 4 yr) served as control (CTRL). Before and after the training period, knee extensors muscle thickness (Tm),
pennation angle () and fascicle length (Lf) of the vastus lateralis muscle, were measured by ultrasound. Maximum isokinetic knee extensor torque (MIT) at an angular velocity of 60 deg/s was measured by dynamometry. After the training, Tm increased by 7.1% (P<0.001), Lf by 5.4% (P<0.02) and by 3.4% (P<0.05). The increase in Tm was matched by a significant gain in MIT (13.3%, P<0.001). No
significant changes, except for a decrease in (2.1%, P<0.02) were found in the CTRL group. The gain in Tm in the training group significantly correlated with an increase in focal adhesion kinase (FAK) content, pointing to a primary role of this mechano-sensitive protein in sarcomere remodeling with muscle hypertrophy. Overall, the results show that alpine skiing is an effective intervention for combating sarcopenia and weakness in old age
Effect of alpine skiing training on tendon mechanical properties in older men and women
No full textStrain is one of the parameters determining tendon adaptation to mechanical stimuli. The aim of this study was to test whether the patellar tendon strain induced during recreational alpine skiing would affect tendon mechanical properties in older individuals. Twenty-two older males and females (67 ± 2 years) were assigned to a 12-week guided skiing programe (IG) and 20 aged-matched volunteers served as controls (CG). Patellar tendon mechanical properties and cross-sectional area (CSA) were measured before and after training, with combined dynamometry and ultrasonography scanning. None of the variables changed significantly in the CG after training. In the IG, tendon stiffness and Young's modulus were increased (respectively, 14% and 12%, P<0.01), without any significant change in tendon CSA. In addition, changes in tendon stiffness were blunted in women (9%) compared with men (19%). Serum IGF-1 concentration tended to be lower in women (-19%, P=0.07). These results demonstrate that the mechanical stimulus induced by alpine skiing is sufficient to elicit adaptive changes in patellar tendon mechanical and material properties in older subjects. Furthermore, the present sex-specific adaptations are consistent with previous reports of lower collagen metabolic responsiveness in women and may be underpinned by anthropometric and metabolic differences. © 2011 John Wiley & Sons A/S
Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength
No full textWe hypothesized that 3-months of downhill skiing mitigates functional deficits of knee extensor muscles in elderly subjects due to specific recruitment of fast motor
units during forceful turns on the slope.
Downhill skiing lead to a 1.4-fold increase in mean cross sectional area of slow (p=0.04) and fast (p=0.08) type muscle fibres. Fold changes in the structural
component of focal adhesions, gamma-vinculin, correlated with alterations in concentric force (r=0.64). Hypertrophy of fast fibres was more important in women than in men (1.7 vs. 1.1). Gender specific structural-functional adjustments of
extensor muscle and attached patellar tendon were reflected by altered expression of pro- vs. de-adhesive proteins and a number of correlations. The de-adhesive protein tenascin-C was selectively increased in women compared to men (1.7 vs. 1.1) while the content of the adhesive collagen XII was specifically reduced by 39% in women. The pro-adhesive focal adhesion kinase showed a specific increase in men (1.9 vs. 1.1). Our findings identify that quantitatively matched adaptations in slow and fast motor units underlie the preventive effect of skiing against sarcopenia and support that
hypertrophy and reinforcement of fibre adhesion in extensor muscle are two myocellular strategies which operate in the improvement of muscle strength
A felnőttkori kötődés és az élettel való elégedettség vizsgálata az életkor függvényében a párkapcsolatban élők és az egyedülállók körében
No full textDiplomamunkámban elsősorban a kötődéssel és az élettel való elégedettséggel foglalkoztam, de kitértem a további esetleges befolyásoló tényezők vizsgálatára is, mint az életkor és a párkapcsolat típusa, gondolok itt az együttélésre, együtt járásra és a házasságra, mint a leggyakoribb kapcsolati formákra. Elemeztem ezen kívül az egyedülállók csoportját, illetve azokat, akiknek soha sem volt kapcsolata és mindezeket a kötődéssel összefüggésben vizsgáltam. A dolgozatomban főképp a fenti kérdésekre kerestem választ az általam elvégzett statisztikai elemzések alapján. A kutatásom során nagyobb rálátást kaphattam a felvetődött kérdésekre, a statisztikai kiértékelések mentén.KEPszichológiaMSc/M
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The Correspondant and the founding of the French Third Republic ::a dissertation /
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Alteration of the Myometrial Plasma Membrane Cholesterol Content with ß-Cyclodextrin Modulates the Binding Affinity of the Oxytocin Receptor
No full textTo investigate the effect of cholesterol on the oxytocin receptor function in myometrial membranes, we developed a new method to alter the membrane cholesterol content. Using a methyl-substituted beta-cyclodextrin, we were able to selectively deplete the myometrial plasma membrane of cholesterol. Vice versa, incubating cholesterol-depleted membranes with a preformed soluble cholesterol-methyl-beta-cyclodextrin complex restored the cholesterol content of the plasma membrane. Binding experiments showed that, with the removal of cholesterol from the membrane, the dissociation constant for [3H]oxytocin is enhanced 87-fold (from Kd = 1.5 nM to Kd = 131 nM), therefore shifting the oxytocin receptor from high to low affinity. Increasing the cholesterol content of the cholesterol-depleted membrane again restored the high-affinity binding (Kd = 1.2 nM). The presence of 0.1 mM GTP gamma S did not significantly change the number of high-affinity binding sites for [3H]oxytocin in native plasma membranes, in membranes depleted of cholesterol, and in plasma membranes with restored cholesterol content. The number of high-affinity binding sites for the oxytocin antagonist [3H]PrOTA was dependent in the same way on the cholesterol content as for [3H]oxytocin. Substitution of the membrane cholesterol with other steroids showed a strong dependence of the oxytocin receptor function on the structure of the cholesterol molecule. The detergent-solubilized oxytocin receptor was not saturable with [3H]oxytocin even at concentrations up to 10-6 M of radioligand. Addition of the cholesterol-methyl-beta-cyclodextrin complex to the detergent-solubilized oxytocin receptor induced a saturation of the solubilized binding sites (Bmax = 0.98 pmol/mg) for oxytocin (Kd = 16 nM
Molecular structure analysis of the pituitary adenylate cyclase activating polypeptide type I receptor from pig brain
No full textIn pig brain a type I receptor for pituitary adenylate cyclase activating polypeptide (PACAP) has been identified and structurally characterized. Scatchard analysis of the equilibrium binding data indicates a single class of binding sites with Kd of 0.50 nM and Bmax of 2.52 pmol/mg. The receptors could be efficiently solubilized with 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1- propanesulfonate (Chapso) without altering their ligand binding parameters (Kd = 0.60 nM; Bmax = 2.46 pmol/mg). In both preparations the ligand-receptor complex was identified as a 68 kDa polypeptide by affinity crosslinking with 125I-PACAP-27 and disuccinimidyl suberate. Employment of nonreducing conditions decreased the electrophoretic mobility of the complex to a 60 kDa species suggesting that the native PACAP receptor exists in a compact conformation stabilized by intramolecular disulfide bridges. Disulfide bonds are also important for the ligand binding activity of the PACAP receptor since pretreatment of the membranes with dithiothreitol led to complete inhibition of PACAP binding and to 61% dissociation of the ligand-receptor complex. Among different sulfhydryl selective reagents tested, p-chloromercuriphenylsulfonic acid was found to inhibit PACAP binding to its receptor in a dose-dependent fashion (IC50 = 0.5 mM) suggesting that one or more sulfhydryl groups are located close to the ligand binding domain of the receptor. Desialylation of the affinity-labeled PACAP receptor with neuraminidase revealed a 61 kDa protein, whereas deglycosylation with N-glycosidase F decreased the M(r) to 52,000. Chromatography on a series of lectin agaroses showed the highest affinity for wheat germ agglutinin (WGA). WGA was also effective in dose-dependent inhibition of PACAP binding activity. Our results characterize the pig PACAP receptor as a tri- or tetraantennary non- or low fucosylated complex type glycoprotein with a protein core of about 49 kDa containing several terminal sialyl residues
Doctoring with the library
No full textMany medicine and dentistry students aspire to continue their research or academic career after graduation, leading them to choose a doctorate. Mainz University Medical School receives around 250 to 300 doctoral thesis submissions annually, and the Departmental Library of Mainz University Medical School (BBUM) plays a crucial part in this process. During the four-year PhD programme, the BBUM provides a variety of indispensable services, courses and resources for doctoral candidates. The poster illustrates how the BBUM endeavours to assist, advise, educate and communicate with its PhD students. Additionally, it outlines the key partnerships, both formal and informal, with other stakeholders.Viele Medizin- und Zahnmedizinstudierende streben nach dem Studium eine weitere Forschungs- oder akademische Karriere an und entscheiden sich daher für eine Promotion. Die Universitätsmedizin Mainz verzeichnet jährlich etwa 250 bis 300 Promotionsarbeiten, wobei die Bereichsbibliothek Universitätsmedizin Mainz (BBUM) eine wichtige Rolle spielt. Während der vierjährigen Promotion stellt die BBUM eine Reihe unverzichtbarer Dienstleistungen, Kurse und Ressourcen für Doktoranden bereit. Das Poster zeigt, wie die BBUM ihre Doktoranden unterstützt, leitet, informiert und zuhört. Außerdem werden die wichtigsten formellen und informellen Kooperationen mit anderen Interessenvertretern präsentiert
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