812 research outputs found
COSCA (Core Outcome Set for Cardiac Arrest) in adults : an advisory statement from the International Liaison Committee on Resuscitation
No full textCardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The Core Outcome Set for Cardiac Arrest (COSCA) initiative, a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation, sought to develop a consensus core outcome set for cardiac arrest for effectiveness trials. Core outcome sets are primarily intended for large, randomized clinical effectiveness trials (sometimes referred to as pragmatic trials, phase III/IV trials) rather than for pilot or efficacy studies.
A systematic review of the literature combined with qualitative interviews among cardiac arrest survivors was used to generate a list of potential outcome domains. This list was prioritized through a Delphi process, which involved clinicians, patients, and their relatives/partners. An international advisory panel narrowed these down to 3 core domains by debate leading to consensus. The writing group refined recommendations for when these outcomes should be measured and further characterized relevant measurement tools.
Consensus emerged that a core outcome set for reporting on effectiveness studies of cardiac arrest (COSCA) in adults should include survival, neurologic function, and health-related quality of life. This should be reported as survival status and modified Rankin Scale score at hospital discharge and / or 30 days. Health-related quality of life should be measured by using 1 or more tools from Health Utilities Index version 3, Short-Form 36-Item Health Survey, EuroQol 5D-5L at 90 days and at periodic intervals up to 1 year after cardiac arrest, if resources allow
Towards the COSCA framework for “COnseptualing Secure CArs”
No full textCyber risks associated with modern cars are often referred to safety. However, modern cars expose a variety of digital services and process a variety of personal data, at least of the driver's. This paper unfolds the argument that car (cyber-)security and drivers' privacy are worthy of additional consideration, and does so by advancing “COSCA”, a framework for “COnceptualising Secure CArs” as interconnected nodes of the Next Generation Internet. COSCA adopts an innovative socio-technical approach. It crowdsources drivers' perceptions on core privacy topics and it classifies the data collected by cars and processed by manufacturers pursuant the General Data Protection Regulation. These steps inform a risk assessment which highlights the more relevant mitigation strategies and cyber security technologies. Finally, COSCA aims at designing novel interfaces to enable drivers to exercise their rights about personal data collection and processing
COSCA (Core Outcome Set for Cardiac Arrest) in Adults : An Advisory Statement From the International Liaison Committee on Resuscitation
No full textCardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation, sought to develop a consensus core outcome set for cardiac arrest for effectiveness trials. Core outcome sets are primarily intended for large, randomised clinical effectiveness trials (sometimes referred to as pragmatic trials or phase III/IV trials) rather than for pilot or efficacy studies. A systematic review of the literature combined with qualitative interviews among cardiac arrest survivors was used to generate a list of potential outcome domains. This list was prioritised through a Delphi process, which involved clinicians, patients, and their relatives/partners. An international advisory panel narrowed these down to 3 core domains by debate that led to consensus. The writing group refined recommendations for when these outcomes should be measured and further characterised relevant measurement tools. Consensus emerged that a core outcome set for reporting on effectiveness studies of cardiac arrest (COSCA) in adults should include survival, neurological function, and health-related quality of life. This should be reported as survival status and modified Rankin scale score at hospital discharge, at 30 days, or both. Health-related quality of life should be measured with >= 1 tools from Health Utilities Index version 3, Short-Form 36-Item Health Survey, and EuroQol 5D-5L at 90 days and at periodic intervals up to 1 year after cardiac arrest, if resources allow. (C) 2018 European Resuscitation Council and American Heart Association, Inc. Published by Elsevier B.V. All rights reserved.Peer reviewe
The northernmost CAMP: Ar/Ar age, petrology and Sr-Nd-Pb isotope geochemistry of the Kerforne dike, Brittany, France
No full textP-COSCA (Pediatric Core Outcome Set for Cardiac Arrest) in children : an advisory statement from the International Liaison Committee on Resuscitation
No full textStudies of pediatric cardiac arrest use inconsistent outcomes, including return of spontaneous circulation and short-term survival, and basic assessments of functional and neurological status. In 2018, the International Liaison Committee on Resuscitation sponsored the COSCA initiative (Core Outcome Set After Cardiac Arrest) to improve consistency in reported outcomes of clinical trials of adult cardiac arrest survivors and supported this P-COSCA initiative (pediatric COSCA). The P-COSCA Steering Committee generated a list of potential survival, life impact, and economic impact outcomes and assessment time points that were prioritized by a multidisciplinary group of healthcare providers, researchers, and parents/caregivers of children who survived cardiac arrest. Then, expert panel discussions achieved consensus regarding the core outcomes, the methods to measure those core outcomes, and the timing of the measurements. The P-COSCA includes assessment of survival, brain function, cognitive function, physical function, and basic daily life skills. Survival and brain function were assessed at discharge or 30 days (or both if possible) and between 6 and 12 months postarrest. Cognitive function, physical function, and basic daily life skills were assessed between 6 and 12 months after cardiac arrest. Because many children have prearrest comorbidities, the P-COSCA also includes documentation of baseline (ie, prearrest) brain function and calculation of changes after cardiac arrest. Supplementary outcomes of survival, brain function, cognitive function, physical function, and basic daily life skills are assessed at 3 months and beyond 1 year after cardiac arrest if resources are available
Exhumation history of eastern Ladakh revealed by Ar-40/Ar-39 and fission-track ages: the Indus River-Tso Morari transect, NW Himalaya
No full textFission-track and Ar-40/Ar-39 ages place time constraints on the exhumation of the North Himalayan nappe stack, the Indus Suture Zone and Molasse, and the Transhimalayan Batholith in eastern Ladakh (NW India). Results from this and previous studies on a north-south transect passing near Tso Morari Lake suggest that the SW-directed North Himalayan nappe stack (comprising the Mata, Tetraogal and Tso Morari nappes) was emplaced and metamorphosed by c. 50-45 Ma, and exhumed to moderately shallow depths (c. 10 km) by c. 45-40 Ma. From the mid-Eocene to the present, exhumation continued at a steady and slow rate except for the root zone of the Tso Morari nappe, which cooled faster than the rest of the nappe stack. Rapid cooling occurred at c. 20 Ma and is linked to brittle deformation along the normal Ribil-Zildat Fault concomitant with extrusion of the Crystalline nappe in the south. Data from the Indus Molasse suggest that sediments were still being deposited during the Miocene
The northernmost CAMP: Ar/Ar age, petrology and Sr-Nd-Pb isotope geochemistry of the Kerforne dike, Brittany, France
No full textCOMPARING THE PROFITABILITY OF CASSAVA-BASED PRODUCTION SYSTEMS IN THREE WEST AFRICAN COUNTRIES: COTE D'IVOIRE, GHANA AND NIGERIA
No full textSub-Saharan Africa (SSA) cassava-producing countries such as Nigeria, Ghana, and Côte d'Ivoire have developed, in recent years, a renewed interest in cassava as an alternative food crop. This has led to a major expansion in cassava-based production systems in Nigeria and Ghana, whereas there has been a slower growth in Côte d'Ivoire (Nweke et al., 1998). This paper is based on the argument that the difference in various factors such as agricultural policies (i.e., trade and price policies, domestic production taxes or subsidies), location and technologies (production and processing) between Nigeria, Ghana and Côte d'Ivoire the difference in the level of growth in cassava-based production systems. The paper examines, using the Policy Analysis Matrix (PAM), the magnitude of the impact of these factors on the private and social profitability of cassava production and post-production processing in Côte d'Ivoire, Ghana and Nigeria. The topic has not been examined in previous studies. The paper relies primarily on data for Côte d'Ivoire, Ghana and Nigeria from the Collaborative Study of Cassava in Africa (COSCA) survey. The baseline results demonstrate the similarity in efficiencies of production in these West African countries. The simulation findings indicated that, in Côte d'Ivoire, farmers benefited from the depreciation of the equilibrium exchange rate while farmers in Ghana and Nigeria suffered losses. Simulation results also indicated that Ivorian and Ghanaian cassava/maize farmers could benefit from growing IITA's improved variety and adopting mechanized processing methods.Crop Production/Industries,
Integrated stratigraphy of lower Miocene sections in the Emilian Apennines (Italy): Biostratigraphy and geochronology.
No full textMicrostructural controls on intragranular argon diffusion in naturally deformed muscovites
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