14 research outputs found
Ovarian function recovery in breast cancer patients receiving adjuvant anastrozole treatment:updated results from the phase 3 DATA trial
No full textPURPOSE: Patients with chemotherapy-induced ovarian function failure (CIOFF) may experience ovarian function recovery (OFR). Earlier, we showed that OFR during treatment with anastrozole impacted the prognosis of hormone receptor-positive (HR+) breast cancer (BC) patients with CIOFF. Here, we present the long-term follow-up results. METHODS: Postmenopausal women with HR+ BC who were 45-57 years of age and received chemotherapy were identified from the phase 3 DATA study (NCT00301457) on the extended use of anastrozole. Eligible patients were categorised into two groups: patients with CIOFF and definitely postmenopausal patients. Patients with CIOFF were monitored for OFR. Disease-free survival (DFS), distant recurrence-free survival (DRFS), and overall survival (OS) were compared between patients with OFR and patients without OFR using multivariable Cox regression analyses, including OFR as a time-dependent covariate. BC-specific mortality (BCSM) was compared between groups using the Fine and Gray method. RESULTS: This study included 656 patients: 395 patients with CIOFF and 261 definitely postmenopausal patients. OFR occurred in 39 (12%) of 329 patients with CIOFF who were monitored for OFR. The median follow-up time was 13.3 years. Patients with OFR experienced a deterioration in DFS (hazard ratio (HR) = 1.54; 95% confidence interval (CI) 0.85-2.81), DRFS (HR = 1.51; 95% CI 0.73-3.11), OS (HR = 1.64; 95% CI 0.75-3.55), and BCSM (subdistribution HR = 1.98; 95% CI 0.84-4.63) when compared with patients without OFR. CONCLUSION: In patients with CIOFF, OFR during treatment with anastrozole was associated with a deterioration in BC outcomes. These findings underscore the importance of adequate ovarian function suppression in this subgroup of patients
Efficacy of anastrozole after tamoxifen in early breast cancer patients with chemotherapy-induced ovarian function failure
No full textThe DATA study (NCT00301457) compared 6 and 3 years of anastrozole in postmenopausal women with hormone receptorpositive early breast cancer after 2–3 years of tamoxifen. Patients with chemotherapy-induced ovarian function failure (CIOFF)
were also eligible, but could be at risk of ovarian function recovery (OFR). The current analysis compared the survival of women
with CIOFF with definitely postmenopausal women and examined the influence of OFR on survival. Therefore, we selected
patients from the DATA study aged 45–57 years at randomization who had received (neo)adjuvant chemotherapy. They were
classified by reversibility of postmenopausal status: possibly reversible in case of CIOFF (n = 395) versus definitely
postmenopausal (n = 261). The former were monitored by E2 measurements for OFR. The occurrence of OFR was incorporated
as a time-dependent covariate in a Cox-regression model for calculating the hazard ratio (HR). We used the landmark method
to calculate residual 5-year survival rates. When comparing CIOFF women with definitely postmenopausal women, the survival
was not different. Among CIOFF women with available E2 follow-up values (n = 329), experiencing OFR (n = 39) had an
unfavorable impact on distant recurrence-free survival (HR 2.27 [95% confidence interval [CI] 0.98–5.25; p = 0.05] and overall
survival (HR 2.61 [95% CI 1.11–6.13; p = 0.03]). After adjusting for tumor features, the HRs became 2.11 (95% CI 0.89–5.02;
p = 0.09) and 2.24 (95% CI 0.92–5.45; p = 0.07), respectively. The residual 5-year rate for distant recurrence-free survival was
76.9% for women with OFR and 92.1% for women without OFR, and for 5-year overall survival 80.8% and 94.4%, respectively.
Women with CIOFF receiving anastrozole may be at increased risk of disease recurrence if experiencing OFR
Efficacy of anastrozole after tamoxifen in early breast cancer patients with chemotherapy-induced ovarian function failure
No full textThe DATA study (NCT00301457) compared 6 and 3 years of anastrozole in postmenopausal women with hormone receptor-positive early breast cancer after 2-3 years of tamoxifen. Patients with chemotherapy-induced ovarian function failure (CIOFF) were also eligible, but could be at risk of ovarian function recovery (OFR). The current analysis compared the survival of women with CIOFF with definitely postmenopausal women and examined the influence of OFR on survival. Therefore, we selected patients from the DATA study aged 45-57 years at randomization who had received (neo)adjuvant chemotherapy. They were classified by reversibility of postmenopausal status: possibly reversible in case of CIOFF (n = 395) versus definitely postmenopausal (n = 261). The former were monitored by E2 measurements for OFR. The occurrence of OFR was incorporated as a time-dependent covariate in a Cox-regression model for calculating the hazard ratio (HR). We used the landmark method to calculate residual 5-year survival rates. When comparing CIOFF women with definitely postmenopausal women, the survival was not different. Among CIOFF women with available E2 follow-up values (n = 329), experiencing OFR (n = 39) had an unfavorable impact on distant recurrence-free survival (HR 2.27 [95% confidence interval [CI] 0.98-5.25; p = 0.05] and overall survival (HR 2.61 [95% CI 1.11-6.13; p = 0.03]). After adjusting for tumor features, the HRs became 2.11 (95% CI 0.89-5.02; p = 0.09) and 2.24 (95% CI 0.92-5.45; p = 0.07), respectively. The residual 5-year rate for distant recurrence-free survival was 76.9% for women with OFR and 92.1% for women without OFR, and for 5-year overall survival 80.8% and 94.4%, respectively. Women with CIOFF receiving anastrozole may be at increased risk of disease recurrence if experiencing OFR
The effect of previous performance on ratings of present performance : examintaion of order effects in an integrative setting
No full textThe occurrence of order effects in performance ratings is documented in both interviewing and performance appraisal literature. Studies have found evidence for both assimilation and contrast effects, but inconsistently. The thesis of the present study was that the major type of comparison required in the setting (comparisons within- or between-ratee) determines whether assimilation, contrast, or no effect occurs. To test this thesis, the study examined the existence of order effects in a setting which integrated both types of comparisons. Two ratees, each with inconsistent performance levels, were rated. Undergraduates (N = 200) read and rated behavioral diaries of two instructors, each including two descriptions of a consistent poor or good performance level, followed by one description of an inconsistent average performance level, or including three descriptions of a consistent average performance level. The consistent performance levels of the two instructors were either similar (Similar CP) or different (Different CP). The integrative setting produced contrast effects in ratings of the first rate and contrast and assimilation effects in ratings of the second ratee (unlike the within-ratee setting). For the second ratee, contrast effects occurred in the Similar CP conditions, while assimilation effects occurred in the Different CP conditions. In addition, overall evaluations and pay and promotion recommendations generally reflected the consistent performance level. Within-ratee order effects had only minor influence on these measures. Finally, between ratee contrast effects occurred in overall evaluations and recommendations. Theoretical, practical, and research implications of these results were discussed.Psychology, Department o
Ressenyes Caplletra 45
No full textLluís Gimeno Betí, ressenya de Joan Coba Femenia, Els adjectius possessius; teoria i alguns problemes d'ús, Barcelona, Publicacions de l'Abadia de Montserrat («Textos i Estudis de Cultura Catalana», 101), 2005, 237 pp.Joaquim Martí Mestre, ressenya d'Antoni Ferrando & Miquel Nicolás, Història de la llengua catalana, Barcelona, Pòrtic Editorial / UOC, 2005, 540 pp.Àngels Campos, ressenya de Teresa Cabré & Josefa Gómez de Enterría, La enseñanza de los lenguajes de especialidad. La simulación global, Madrid, Gredos, 2006, 164 pp.Joan Castaño, ressenya de Francesc Massip & Lenke Kovács, El baile: conjuro ante la muerte. Presencia de lo macabro en la Danza y la Fiesta Popular, Ciudad Real, CIOFF España, 2004, 210 pp., més il·lustracions.Josep M. Castellà Lidon, M. Josep Cuenca, La connexió i els connectors. Perspectiva oracional i textual, Vic, Eumo, 2006, 222 pp.Maria Bayarri, ressenya de Franceesco Ardolino, Una literatura entre el dogma i l'heretgia. Les influències de Dante en l'obra de Joan Maragall, Barcelona, Editorial Cruïlla / Fundació Joan Maragall Cristianisme i Cultura, 2006, 139 pp.
Femtosecond laser ablation synthesis of hybrid copper chitosan nanoantimicrobials
No full textFemtosecond laser ablation for copper particles is describe
Synthesis and characterizations of melamine-based epoxy resins
No full textA new, easy and cost-effective synthetic procedure for the preparation of thermosetting melamine-based epoxy resins is reported. By this innovative synthetic method, different kinds of resins can be obtained just by mixing the reagents in the presence of a catalyst without solvent and with mild curing conditions. Two types of resins were synthesized using melamine and a glycidyl derivative (resins I) or by adding a silane derivative (resin II). The resins were characterized by means of chemical-physical and thermal techniques. Experimental results show that all the prepared resins have a good thermal stability, but differ for their mechanical properties: resin I exhibits remarkable stiffness with a storage modulus value up to 830 MPa at room temperature, while lower storage moduli were found for resin II, indicating that the presence of silane groups could enhance the flexibility of these materials. The resins show a pot life higher than 30 min, which makes these resins good candidates for practical applications. The functionalization with silane terminations can be exploited in the formulation of hybrid organic-inorganic composite materials
Intracochlear auditory nerve monitoring and cochlear implantation after total resection of a vestibular schwannoma : case report
No full textAbstract: The aim is to present a case of cochlear implantation (CI) after vestibular schwannoma (VS) resection and intracochlear auditory nerve monitoring. The case of a 53-year-old man with left -sided iatrogenic dehiscence of the posterior semicircular canal after VS resection using the retrosigmoid approach is reported. Because of third mobile window symptoms, transmastoid plugging of the posterior and superior semicircular canal was carried out. In the following 3 years, ipsilateral hearing problems and tinnitus loudness increased, and therefore CI was considered. To investigate the electrophysiological status of the left cochlear nerve, intraoperative auditory nerve monitoring was performed using the Auditory Nerve Test System (ANTS). Audiological assessments included tinnitus evaluation, speech perception in noise, and sound localization. Because reliable electrical auditory brainstem response waveforms were found during intracochlear ANTS testing, supporting the integrity of cochlear nerve function, CI was performed during the same surgery using a flexible 34 -mm electrode array. Audiological evaluation 3 months after CI activation showed a significant positive effect of CI usage on tinnitus loudness (8/10 in the CIOFF condition going to 0/10 in the CION condition). Moreover, speech perception in noise and localization testing showed restored binaural hearing in the CION condition. Cochlear implantation was found to be successful in a single -sided deaf case with iatrogenic dehiscence of the posterior semicircular canal after VS resection. Prior to implantation, intraoperative ANTS measurement proved integrity of the cochlear nerve function and therefore has the ability to guide the decision of placing a CI after VS resection in case of preservation of cochlear nerve function
Полиморфизм вставки/делеции гена АПФ связан с глиобластомой у населения Ирана: исследование случай-контроль
No full textBackground. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been reported to be associated with the pathogenesis and development of human cancers.This study aimed to assess the potential association between ACE (I/D) polymorphism and glioblastoma in an Iranian population.Material and Methods. This case-control study was conducted on 80 patients with glioblastoma and 80 healthy blood donors as controls. Gap-polymerase chain reaction (Gap-PCR) was used to determine the ACE (I/D) genotypes. PCR products were separated and measured by electrophoresis on a 2 % agarose gel.Results. Analysis of demographic data showed a significant difference in the family history of cancer between the case and control groups (p=0.03). The distribution of ACE gene variants including II, ID, and DD genotypes was also calculated, and significant differences were seen in the DD genotype (p=0.03) and D allele (p=0.04) between the glioblastoma cases and controls.Conclusion. ACE gene polymorphism was associated with glioblastoma in the study population. Further studies are needed to approve this finding.Актуальность. Недавно сообщалось, что инсерционно-делеционный (I/D) полиморфизм гена ангиотензин-превращающего фермента (АПФ) связан с патогенезом и развитием рака человека.Целью исследования была оценка потенциальной связи между I/D полиморфизмом гена АПФ и глиобластомой у населения Ирана.Материал и методы. В исследовании случай-контроль участвовали 80 пациентов с глиобластомой и 80 здоровых доноров в качестве группы контроля. Полимеразная цепная реакция (Gap-PCR) использовалась для определения генотипов I/D полиморфизма гена AПФ. ПЦР-продукты разделяли и измеряли электрофорезом в 2 % агарозном геле.Результаты. Анализ демографических данных показал значительную разницу в семейной истории рака между основной и контрольной группами (p=0,03). Было рассчитано распределение вариантов гена АПФ, включая генотипы II, ID и DD, и были обнаружены значительные различия в генотипе DD (p=0,03) и аллеле D (p=0,04) между группой больных с глиобластомой и контрольной группой.Заключение. Полиморфизм гена AПФ был связан с глиобластомой в исследуемой популяции. Необходимы дальнейшие исследования, чтобы подтвердить эти данные
