4,117 research outputs found
The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications
No full textOriginally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare histopathological and molecular findings from experimental models of PD and human studies. We moreover discuss the important role played by astrocytes in compensatory adaptations taking place during presymptomatic disease stages. We finally describe examples of potential therapeutic applications stemming from an increased understanding of the important roles of glia in PD
Data from Burato, M., Tang, S., Vastola, V. and Cenci, S. Organizational system thinking as a cognitive framework to meet climate targets Proc.Natl.Acad.Sci. USA
No full textThe folder includes the code and the derived measure of organisational system thinking, see the ReadMe.pdf file for further detail. Reproducing the results requires access to additional datasets that cannot be shared by us
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A Critical Study of The Cenci
No full textConsciously or unconsciously an author's literary work reflects his experiences and his reaction to these experiences. Because the personal history of the author is inseparable from his works, a study of The Cenci would be incomplete without a review of the background of Shelley's life, some of the philosophies which interested him, and the political and social movements with which he concerned himself
Pucci S., Cenci M., Luly R. (2013), Analysis of the relationship between book value and market value in the bank sector: the impact of information on intangibles presented in financial statements
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Dynamic Portfolio Selection in a Dual Expected Utility Theory Framework
No full textIn this paper the dynamic portfolio selection problem is studied for the first time
in a dual utility theory framework. The Wang transform is used as distortion
function and well diversified optimal portfolios result both with and without
short sales allowed
Numerical analysis of a laboratory centrifugal pump for the training of graduate engineers
No full textThe up-to-date design of turbomachinery involves the use of three dimensional computational fluid dynamic analyses to match the challenge of the ever increasing speed of the product development. Recently, these analyses applied to turbomachinery, which in past years were confined to special fields, have became widespread in many industrial applications. Hence, besides the teachings of traditional methods for turbomachinery design, an important part of modern engineering education is to produce graduates with advanced skills in Computational Fluid Dynamics (CFD) techniques applied to turbomachinery design . Moreover, at this time, these skills should either match the needs of research laboratories or be compatible with industrial needs, since three dimensional numerical calculation is becoming to be seen as a feasible tool also in ordinary applications.
For these reasons, CFD courses for the training of graduated and undergraduated students have been grown. To match the requirements of an as complete as possible knowledge of the main features involved in a numerical analysis, a number of different issues should be addressed and properly treated within the course.
In this paper, the methodology followed and the work carried out by the students of the course of the Fluid Dynamic Design of Turbomachinery held at the University of Ferrara is presented. In particular, three levels of investigation are taken into consideration and presented:
(i) the focus in the fundamentals which should be addressed to achieve a basic knowledge of a design process based on numerical simulation;
(ii) the extension to an higher level of in-depth analyses of the specific models which could be used in every phase of a numerical simulation;
(iii) the insight into the specificity of the main thermodynamic and fluid dynamic characteristics of turbomachinery.
To do this, the numerical analysis of a simple but exhaustive geometry (a laboratory centrifugal pump for which extensive information are available in literature) has been carried out and the results obtained are addressed. In particular, special emphasis is devoted to the comparison among the numerical models which can be chosen throughout the simulations of turbomachinery (turbulence models, rotor/stator interface, etc.) and the analysis of the most important fluid dynamic phenomena inside a centrifugal pump
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