149 research outputs found
Cognitive frailty: what is still missing?
No full textIn recent years, the complex relationship between frailty and cognitive functioning has been increasingly investigated. Accordingly, the concept of "cognitive frailty" was recently proposed to describe a clinical condition characterized by the simultaneous occurrence of both physical frailty and cognitive impairment, in absence of overt dementia diagnosis or underlying neurological conditions. This novel construct has several elements of novelty and may delineate a promising target for preventive and therapeutic actions against age-related conditions. In the present paper we discuss the main issues that are still limiting the clinical and research implementation of the cognitive frailty construct. In particular, a) how to operationalize its definition; b) the supporting epidemiological data; and c) the underlying clinical and biological characteristics constitute points that need to be addressed and clarified
Editorial: Dementia, Frailty and Aging
No full text10.3389/fmed.2018.00168Frontiers in Medicine5MAY16
Transcranial direct current stimulation as a therapeutic opportunity in PSP
No full textNo abstract availabl
Migration and dementia in Europe: Towards a culturally competent approach and provision of care
No full textFrailty and cognitive decline: how do they relate
No full textPURPOSE OF REVIEW:
To provide a comprehensive review of the recent literature (published over the last 12 months) exploring the relationship between frailty and cognition.
RECENT FINDINGS:
Fourteen studies were retained for the present review. No randomized controlled trial was found. Overall, the main findings of the selected studies appeared to be mainly confirmatory of the previous evidence. In longitudinal studies, physical frailty was found to predict the incidence of cognitive impairment and dementia. Cross-sectional studies showed that frail individuals have lower cognitive performance compared with nonfrail persons. Interestingly, few studies examined the association between frailty and specific cognitive functions and domains, reporting a significant impairment of attention and executive functions Finally, we found several studies including cognitive measures in the operational definitions of frailty.
SUMMARY:
The present findings are suggestive of an almost complete lack
The sterile controversy on the amyloid cascade hypothesis
No full textIn these last years, several phase III randomized controlled trials testing promising candidates sharing Aβ depots as target of their action have failed, despite showing some reductions of the brain Aβ charge. The announcements of the negative results have heated the discussion in the field and divided the scientific community between the defenders versus the opponents of the Aβ theory. In the present article, we discuss the limits of these drastic, opposite positions and we propose a novel approach to Alzheimer's disease (AD). In particular, a "one-fits-all" approach where a single biomarker/process is able to explain the clinical manifestation seems inadequate for AD (as for other conditions of old age). Accordingly, there is an urgent need to overcome the traditional paradigms of "standalone-diseases" (requiring unimodal interventions) in favor of more comprehensive and multidimensional approaches. Specifically, promoting biomarker modeling procedures based on multivariate statistical methodologies may have important implications and advantages in the field of AD and other neurodegenerative diseases
Baseline assessment of physical frailty in neurological drug development
No full textNo abstract availabl
Providing Simultaneous COVID-19–sensitive and Dementia-Sensitive Care as We Transition from Crisis Care to Ongoing Care
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