2,001 research outputs found
Actomyosin Pulsing in Tissue Integrity Maintenance during Morphogenesis
No full textThe actomyosin cytoskeleton is responsible for many changes in cell and tissue shape. For a long time, the actomyosin cytoskeleton has been known to exhibit dynamic contractile behavior. Recently, discrete actomyosin assembly/disassembly cycles have also been observed in cells. These so-called actomyosin pulses have been observed in a variety of contexts, including cell polarization and division, and in epithelia, where they occur during tissue contraction, folding, and extension. In epithelia, evidence suggests that actomyosin pulsing, and more generally, actomyosin turnover, is required to maintain tissue integrity during contractile processes. This review explores possible functions for pulsing in the many instances during which pulsing has been observed, and also highlights proposed molecular mechanisms that drive pulsing
Dataset and code supporting Cornelis et al. 2023. Stuck in the weeds: Invasive grasses reduce tiger snake movement
No full textData and code used in the publication:
Cornelis, J., Cooper, C. E., Lettoof, D. C., Mayer, M., Marshall, B. M. 2023 Stuck in the weeds: Invasive grasses reduce tiger snake movement. bioRxiv 2023.03.06.531246; doi: https://doi.org/10.1101/2023.03.06.531246
Includes telemetry data, aKDE, dBBMM, and Bayesian model specification and results, code to reproduce analysis and generate figure
High quality testing of grid style power gating
No full textThis paper shows that existing delay-based testing techniques for power gating exhibit fault coverage loss due to unconsidered delays introduced by the structure of the virtual voltage power-distribution-network (VPDN). To restore this loss, which could reach up to 70.3% on stuck-open faults, we propose a design-for-testability (DFT) logic that considers the impact of VPDN on fault coverage in order to constitute the proper interface between the VPDN and the DFT. The proposed logic can be easily implemented on-top of existing DFT solutions and its overhead is optimized by an algorithm that offers trade-off flexibility between test-application-time and hardware overhead. Through physical layout SPICE simulations, we show complete fault coverage recovery on stuck-open faults and 43.2% test-application-time improvement compared to a previously proposed DFT technique. To the best of our knowledge, this paper presents the first analysis of the VPDN impact on test qualit
The relationship between pain intensity and severity and depression in older people: exploratory study
No full textBackground: Pain and depression are known to be associated in later life, and both have a negative effect on physical performance both separately and in combination. The nature of the relationships between pain intensity and depression in elderly persons experiencing pain is less clear. The objectives of this study were to explore which factors are associated with depressed mood in older people experiencing pain, and to test the hypothesis that older people experiencing pain are at risk of depressed mood according to the severity or frequency of their pain. In addition we explored whether other potentially modifiable factors might increase the risk of depressed mood in these persons.Methods: The study is a secondary analysis of baseline data for four hundred and six community-dwelling non-disabled people aged 65 and over registered with three group practices in suburban London who had experienced pain in the past 4 weeks. Intensity and frequency of pain was measured using 24 item Geriatric Pain Measure (GPM) and the presence of depressive symptoms using the 5 item Mental Health Inventory. Risk for social isolation was measured using the 6 item Lubben Social Network scale and instrumental activities of daily living (IADL) were also measured.Results: Overall 76 (19%) had depressed mood. Pain frequency and severity were not statistically significantly associated with depressed mood in this population. In multivariate analyses, significant predictors of the presence of depressive symptoms were difficulties with basic ADLs (OR 2.8, 95% CI 1.1.7.8), risk for social isolation (OR 4.1, 95% CI 1.8-9.3), and basic education only (OR 2.2, 95% CI 1.1-4.4).Conclusion: Older people experiencing pain are also likely to experience depression. Among those experiencing pain, social network and functional status seem to be more important predictors of depressive symptoms than the severity of pain. Further studies should evaluate whether improvement of social network and functional status might reduce depressive symptoms in older patients
Design of CMOS Checkers with Improved Testability of Bridging and Transistor Stuck-on Faults
No full textThis work presents a design technique for CMOS static and dynamic checkers (to be used in self-checking circuits), that allows the detection of all internal single transistor stuck-on and bridging faults causing unacceptable degradations of the circuit dynamic performance (but not logical errors). Such a technique exploits simple voltage detector circuits to make sure that the intermediate faulty voltages inevitably produced by the faults of interest are always propagated at the checker output as logic errors. With the use of our technique, the main disadvantages of static checkers, so far preventing their use in practical applications, are overcome. The method has been applied to the particular case of two-rail (static as well as dynamic) checkers and its validity has been verified by means of electrical level simulations. © 1995 Kluwer Academic Publishers
Thétis et Pélée
No full textSeconde éd., conformé aux dernières représentationsPrinted from movable type, except p. 81-96 which are from engraved platesText by B. de FontenelleOriginally composed in 1689 ; this is the revised version of 1708, with additional Airs by J.-B. Stuck and A. CampraTable. Airs a jouer and Airs a chanter prelim p. 3-4Signatures: 2 leaves unsigned, A-Qq² (continues through engraved section)This copy has manuscript initial B [Ballard] at head of titleThis copy from the Collection of Louise Hanson-Dye
MIL-M-38510/470 test vectors: Fault detection efficiency measurement via hardware fault simulation
No full textThe stuck fault detection efficiency of the test vectors developed for the MIL-M-38510/470 NASA was measured using a hardware stuck fault simulator for the 1802 microprocessor. Thirty-nine stuck faults were not detected out of a total of 874 injected into the combinatorial and sequential parts of the microprocessor. Since undetected faults can create catastrophic errors in equipment designed for high reliability applications, it is recommended that the MIL-M-38510/470 NASA be enhanced with additional test vectors so as to achieve 100% stuck fault detection efficiency
Pesticide residues and stuck fermentation in wine: New evidences indicate the urgent need of tailored regulations
No full textFor three consecutive years, an Italian winery in Apulia has dealt with sudden alcoholic stuck fermentation in the early stages of vinification process, i.e., typical defects addressable to bacterial spoilage. After a prescreening trial, we assessed, for the first time, the influence of the commercial fungicide preparation Ridomil Gold ® (Combi Pepite), containing Metalaxyl-M (4.85%) and Folpet (40%) as active principles, on the growth of several yeasts (Saccharomyces cerevisiae and non-Saccharomyces spp.) and lactic acid bacteria of oenological interest. We also tested, separately and in combination, the effects of Metalaxyl-M and Folpet molecules on microbial growth both in culture media and in grape must. We recalled the attention on Folpet negative effect on yeasts, extending its inhibitory spectrum on non-Saccharomyces (e.g., Candida spp.). Moreover, we highlighted a synergic effect of Metalaxyl-M and Folpet used together and a possible inhibitory role of the fungicide excipients. Interestingly, we identified the autochthonous S. cerevisiae strain E4 as moderately resistant to the Folpet toxicity. Our findings clearly indicate the urgent need for integrating the screening procedures for admission of pesticides for use on wine grape with trials testing their effects on the physiology of protechnological microbes
Stuck: An advocacy film for verbal abuse
No full textAbstract onlyExposure to verbal abuse especially from a young age may lead to individuals, who grow up believing that these negative labels about them are true correlation with this study is the looking glass theory of Charles Horton on self and social organization where how society dictates for who they are. Stuck is a film intended to show support for those who have suffered and/or still suffer from verbal abuse. As the title suggests, these negative words eventually become “stuck” in the individual’s minds.
The advocacy film was created using the graphic software of Adobe Animate, Premier, and After Effects.
The project gained positive reviews from the ethical committee whom the movie was shown to. The researchers concluded that this thesis project has successfully conveyed the concept of verbal abuse to the people R18 and above who have interest in making the society a better place through the develop animation and film and that the quality of the video verifies the capabilities of the researchers in producing an advocacy film with the mix of animation output.Includes bibliographical referencesBachelor of Science in Digital Media and Interactive Art
Testability and redundancy techniques for improved yield and reliability of CMOS VLSI circuits
No full textThe research presented in this thesis is concerned with the design of fault-tolerant integrated circuits as a contribution to the design of fault-tolerant systems. The economical manufacture of very large area ICs will necessitate the incorporation of fault-tolerance features which are routinely employed in current high density dynamic random access memories. Furthermore, the growing use of ICs in safety-critical applications and/or hostile environments in addition to the prospect of single-chip systems will mandate the use of fault-tolerance for improved reliability. A fault-tolerant IC must be able to detect and correct all possible faults that may affect its operation. The ability of a chip to detect its own faults is not only necessary for fault-tolerance, but it is also regarded as the ultimate solution to the problem of testing. Off-line periodic testing is selected for this research because it achieves better coverage of physical faults and it requires less extra hardware than on-line error detection techniques. Tests for CMOS stuck-open faults are shown to detect all other faults. Simple test sequence generation procedures for the detection of all faults are derived. The test sequences generated by these procedures produce a trivial output, thereby, greatly simplifying the task of test response analysis. A further advantage of the proposed test generation procedures is that they do not require the enumeration of faults. The implementation of built-in self-test is considered and it is shown that the hardware overhead is comparable to that associated with pseudo-random and pseudo-exhaustive techniques while achieving a much higher fault coverage through-the use of the proposed test generation procedures. The consideration of the problem of testing the test circuitry led to the conclusion that complete test coverage may be achieved if separate chips cooperate in testing each other's untested parts. An alternative approach towards complete test coverage would be to design the test circuitry so that it is as distributed as possible and so that it is tested as it performs its function. Fault correction relies on the provision of spare units and a means of reconfiguring the circuit so that the faulty units are discarded. This raises the question of what is the optimum size of a unit? A mathematical model, linking yield and reliability is therefore developed to answer such a question and also to study the effects of such parameters as the amount of redundancy, the size of the additional circuitry required for testing and reconfiguration, and the effect of periodic testing on reliability. The stringent requirement on the size of the reconfiguration logic is illustrated by the application of the model to a typical example. Another important result concerns the effect of periodic testing on reliability. It is shown that periodic off-line testing can achieve approximately the same level of reliability as on-line testing, even when the time between tests is many hundreds of hours
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