3,732 research outputs found
Letter to Robert S. Stevens from M. C. Isaacs & Co., dated 1875-11-01 (from 1875 Book of Letters to R.S.S.)
No full textM. C. Isaacs & Co., Phoenix Steel Wire Broom & Brush WorksThe original of this document is in the Stevens Family Papers, #1210, at the Division of Rare and Manuscript Collections, Cornell University Library, Ithaca, New York 14853
Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Get PDFCorrection to: Nature Genetics https://doi.org/10.1038/ng.3668, published online 26 September 2016.
In the version of the article published, the surname of author Aaron Isaacs is misspelled as Issacs
(above) Cod end of an Isaacs-Kidd midwater trawl bitten by captured Isistius brasiliensis (photo J C Staiger, University of Miami, 10 May 1972); (below) plug of fish tissue found in the stomach of an <i>I</i>. <i>brasiliensis</i> caught in Isaacs-Kidd midwater trawl (photo M J Miller, Atmosphere and Ocean Research Institute, University of Tokyo, Japan).
No full text(above) Cod end of an Isaacs-Kidd midwater trawl bitten by captured Isistius brasiliensis (photo J C Staiger, University of Miami, 10 May 1972); (below) plug of fish tissue found in the stomach of an I. brasiliensis caught in Isaacs-Kidd midwater trawl (photo M J Miller, Atmosphere and Ocean Research Institute, University of Tokyo, Japan).</p
Impact of ceria support morphology on Au single‐atom catalysts for benzyl alcohol selective oxidation
Get PDFAlcohol oxidations are a key industrial chemical transformation, with aldehydes and ketones finding use in an array of applications. Nobel metals are known for their activity towards this chemoselective transformation, however, sustainable catalyst synthesis requires optimal utilisation of these scarce elements. Here, we report Au catalytic systems based on the deposition of isolated Au sites on different morphologies of ceria in which different surface facets of the support are exposed. Through tailoring the support morphology and from extensive catalyst characterisation, it is shown that the exposed facet is critical for controlling the formation (or not) of isolated Au sites. Both the 110 and 111 facets are capable of this feat, yielding single-atom sites for rod, octahedron, and polyhedron morphologies. In contrast, the 100 facet is not, resulting in Au nanoparticles on cubic ceria. This dictation over Au species is critical to benzyl alcohol oxidation capacity at mild conditions and in the absence of a soluble base, with only single-atom catalyst (SAC) systems demonstrating activity. Furthermore, the exposed surface facet also governs the degree of surface oxygen vacancies, which is critical to catalyst activity due to their control over substrate adsorption strength, as revealed through T1/T2 NMR relaxation measurements
Insights from integrated deep-time thermal history modeling; Constraining the burial, exhumation, and long-term stability of the Fennoscandian Shield
No full textSubmission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01The student, Joshua Isaacs, accepted the attached license on 2024-07-16 at 11:43.The student, Joshua Isaacs, submitted this Thesis for approval on 2024-07-16 at 11:55.This Thesis was approved for publication on 2024-07-17 at 14:34.DSpace SAF Submission Ingestion Package generated from Vireo submission #21133 on 2025-02-04 at 21:25:58Cratons, the oldest and thickest sections of the Earth’s lithosphere, are traditionally thought to have stable freeboard and minimal internal deformation over billion-year timescales. However, recent thermochronometric insights and geodynamic predictions suggest that cratons can undergo large vertical motions throughout their existence. Here, I investigate questions related to craton stability with a thermochronologic study of the bedrock of the Fennoscandian Shield in southeastern Finland. This region has a striking lack of sedimentary cover, which previous studies have used, along with inferred paleosurfaces, impact craters, and negligible relief to argue that Fennoscandia has experienced minimal sedimentation since accretion during the Orosirian. However, field observations cannot distinguish strata that never existed from the effects of erosion. By leveraging temperature as a sign of burial, thermochronometry can identify stratigraphy now lost, and this makes it indispensable in deciphering whether cratonic cores are stable across deep time. Cratonic stability has implications for how we plan to dispose of hazardous materials, understand the relationship between tectonics, geodynamics, and erosion, and envision the histories of Earth’s oldest crust. Furthermore, recent work has suggested this area is key to tracing the longest record of habitable conditions for Earth’s deep biosphere. This emerging paleomicrobiology topic requires a thermochronologic perspective to validate the interpretation of long-term habitability. This study presents new zircon (U-Th)/He dates from depths of a single borehole and new apatite (U-Th-Sm)/He dates from one borehole depth in southeastern Finland. Effective uranium (eU) is a proxy for radiation damage, which determines the diffusivity of He in individual grains. The observed negative relationships between date and eU in zircons at all depths indicate prolonged residence above annealing temperatures. Ages of the shallowest sample (35.9 m deep) span 961.1 ± 18.9 to 7.44 ± 0.17 Ma, and the deepest sample (806.1 m) preserves ages from 745.0 ± 12.4 to 12.71 ± 0.18 Ma. Significant overlap in date-eU space demonstrates that the temperature offset across ∼ 70 m vertical separation is not enough to record drastically different thermal information. Inverse thermal history modeling requires well-constrained heating to between 70 and 90 °C in the past 100 Ma while suggesting residence <60 °C in the Mesozoic and much of the Paleozoic. The models also necessitate one older phase of reheating to more than 150 °C before 900 Ma and most likely between 1350 and 1220 Ma. The lack of magmatism in southern Finland from the Mesoproterozoic onwards means that reheating must be the result of burial and exhumation equivalent to several kilometers of vertical variation. Model results independently predict observations and events described throughout Fennoscandian history that significantly increase confidence in the magnitude and timing of results. These findings recontextualize the sub-Cambrian peneplain as resulting from multiple episodes of denudation punctuated by sedimentary burial and suggest that cratonic interiors are anything but stable
Entomological opportunities and challenges for sustainable viticulture in a global market
No full textViticulture has experienced dramatic global growth in acreage and value. As the international exchange of goods has increased, so too has the market demand for sustainably produced products. Both elements redefine the entomological challenges posed to viticulture and have stimulated significant advances in arthropod pest control programs. Vineyard managers on all continents are increasingly combating invasive species, resulting in the adoption of novel insecticides, semiochemicals, and molecular tools to support sustainable viticulture. At the local level, vineyard management practices consider factors such as the surrounding natural ecosystem, risk to fish populations, and air quality. Coordinated multinational responses to pest invasion have been highly effective and have, for example, resulted in eradication of the moth Lobesia botrana from California vineyards, a pest found in 2009 and eradicated by 2016. At the global level, the shared pests and solutions for their suppression will play an increasing role in delivering internationally sensitive pest management programs that respond to invasive pests, climate change, novel vector and pathogen relationships, and pesticide restriction
A novel role for TRPM8 in visceral afferent function
No full textAbstract not availableAndrea M. Harrington, Patrick A. Hughes, Christopher M. Martin, Jing Yang, Joel Castro, Nicole J. Isaacs, L. Ashley Blackshaw, Stuart M. Brierle
NMR diffusion raw data - catalysts
No full textUnderpinning data set for Impact of Porous Silica Nanosphere Architectures on the Catalytic Performance of Supported Sulphonic Acid Sites for Fructose Dehydration to 5-Hydroxymethylfurfural C.-A. H. Price, A. Torres-Lopez, R. Evans, N. S. Hondow, M. A. Isaacs, A. S. Jamal, C. M. A. Parlett, ChemPlusChem 2023, 88, e202300413.https://doi.org/10.1002/cplu.20230041
Importance Sampling for a Markov Modulated Queuing Network with Customer Impatience until the End of Service
Get PDFFor more than two decades, there has been a growing of interest in fast simulation techniques for estimating probabilities of rare events in queuing networks. Importance sampling is a variance reduction method for simulating rare events. The present paper carries out strict deadlines to the paper by Dupuis et al for a two node tandem network with feedback whose arrival and service rates are modulated by an exogenous finite state Markov process. We derive a closed form solution for the probability of missing deadlines. Then we have employed the results to an importance sampling technique to estimate the probability of total population overflow which is a rare event. We have also shown that the probability of this rare event may be affected by various deadline values.Importance Sampling, Queuing Network, Rare Event, Markov Process, Deadline
Deconstructing comprehensibility: identifying the linguistic influences on listeners' L2 comprehensibility ratings
Get PDFComprehensibility, a major concept in second language (L2) pronunciation research that denotes listeners’ perceptions of how easily they understand L2 speech, is central to interlocutors’ communicative success in real-world contexts. Although comprehensibility has been modeled in several L2 oral proficiency scales—for example, the Test of English as a Foreign Language (TOEFL) or the International English Language Testing System (IELTS)—shortcomings of existing scales (e.g., vague descriptors) reflect limited empirical evidence as to which linguistic aspects influence listeners’ judgments of L2 comprehensibility at different ability levels. To address this gap, a mixed-methods approach was used in the present study to gain a deeper understanding of the linguistic aspects underlying listeners’ L2 comprehensibility ratings. First, speech samples of 40 native French learners of English were analyzed using 19 quantitative speech measures, including segmental, suprasegmental, fluency, lexical, grammatical, and discourse-level variables. These measures were then correlated with 60 native English listeners’ scalar judgments of the speakers’ comprehensibility. Next, three English as a second language (ESL) teachers provided introspective reports on the linguistic aspects of speech that they attended to when judging L2 comprehensibility. Following data triangulation, five speech measures were identified that clearly distinguished between L2 learners at different comprehensibility levels. Lexical richness and fluency measures differentiated between low-level learners; grammatical and discourse-level measures differentiated between high-level learners; and word stress errors discriminated between learners of all levels
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