1,059 research outputs found
2. Genetic prothrombotic factors in children with otogenic lateral sinus thrombosis: five case reports
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Genetic prothrombotic factors in children with otogenic lateral sinus thrombosis: five case reports
Author(s): Zangari, P (Zangari, Paola)1; Messia, V (Messia, Virginia)1; Viccaro, M (Viccaro, Marika)2; Bottero, S (Bottero, Sergio)2; Randisi, F (Randisi, Francesco)3; Marsella, P (Marsella, Pasquale)2; Luciani, M (Luciani, Matteo)4; Locatelli, F (Locatelli, Franco)4
Source: BLOOD COAGULATION & FIBRINOLYSIS Volume: 23 Issue: 2 Pages: 158-163 DOI: 10.1097/MBC.0b013e328349cafb Published: MAR 2012
Times Cited: 0 (from Web of Science)
Cited References: 20 [ view related records ] Citation Map
Abstract: Lateral sinus thrombosis (LST) is an uncommon, but life-threatening complication of both acute and chronic otitis media. There is some evidence that acquired or hereditary prothrombotic disorders are risk factors for LST. The aim of this work was to evaluate the role of thrombotic screening, anticoagulant therapy or prophylaxis in patients with either acute or chronic otitis media and LST. The medical records of five children hospitalized at Pediatric Hospital Bambino Gesu of Rome because of acute or chronic otitis media complicated by mastoiditis and LST were reviewed. All children underwent laboratory workup for hypercoagulability. All the five children were found to be heterozygote for the C677T MTHFR mutation and a child presented also heterozygosity for factor V Leiden mutation. They have been successfully treated with anticoagulant therapy without sequels. Children with acute or chronic otitis media may have a prothrombotic tendency that becomes clinically evident because of the inflammatory state. Patients with a family and/or personal history of thrombosis and/or thrombophilic conditions need anticoagulant prophylaxis also in the absence of clear signs of LST. Treatment with low molecular weight is successful in patients with LST. Blood Coagul Fibrinolysis 23:158-163 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
Designing adaptive reuse strategies for cultural heritage with choice experiments
No full textThe introduction of the sustainable development concept in the field of cultural heritage preservation has led relevant changes to traditional interventions on historical buildings and areas. Although the idea of reusing cultural heritage is not new, the emerging concept of adaptive reuse stresses even more the importance of a holistic approach for addressing successful interventions. Selecting among the potential uses the one that could ensure the preservation of physical characters as well as intangible values, fueling economic development, is a challenging policy and design issue. In this context, this paper proposes the use of Choice Experiments to support the design of adaptive reuse strategies for three mostly unused castles in Northern Italy characterized by different states of conservation, accessibility and surrounding territorial contex
Il dolore e l’eterno. Lettura di Per diverse ragioni di Domenico Brancale
No full textThis essay will consist of a critical reading of Per diverse ragioni, the latest collection by the poet Domenico Brancale published in 2017 for Passigli. Through a transversal reading of the poetic text, the main thematic and poetic issues of the author will be analyzed. A second point of interest will be the deepening of the ontological framework and of the conceptual meanings of the collection, and it will be connected to an investigation relating to its formal and philosophical-speculative derivations
Valuing benefits from buildings energy savings: An econometric approach
No full textEnergy certifycation attests the buildings energy performance and it was introduced by the European Directive 2002/91/CE as a tool for supporting information and transparency in real estate markets. The present paper intends to investigate the role of the energy certification in the formation of the market value of an estate. In particular, the study proposes an application of the Hedonic Prices method on a sample of residential buildings located in the city of Torino. The objective of the application is to determine the willingness to pay of the buyers with respect to energy-efficient buildings. The outputs of the research show that the consumers demonstrate to appreciate high energy performance classes and this results is aligned with the main findings coming from other international scientific studies. The obtained results could be further verified through the integration of the proposed approach with the cost-optimal methodology
«Sola nel letto di me stessa» Osservazioni sulla poetica di Biancamaria Frabotta ne "La materia prima"
No full textThis essay focuses on the poetic conception of Biancamaria Frabotta in the collection La materia prima. The literature dedicated to Frabotta’s poetry is to date very wide. However, no studies on the collection have been produced to date. In order to offer an unprecedented insight into Frabotta’s poetic work, the purpose of this study is to perform a study of the textual corpus, approached through a philosophical critical methodology of analysis. Such analysis will be divided into three paragraphs and will focus on the issues raised by the ontological and aesthetical centrality of the figure of the animal, the metaphysical conception of the poet and the theoretical compositional component. The study will provide a new epistemological reading of the second-last poetry collection of Frabotta, which will also allow for a deeper understanding of her work. A new contribution will thus enrich the critical literature on the author both in the sense of the methodology and of the research focus
Systems Engineering and Ship Design: a synergy for getting the right design and the design right
No full textWhat makes a successful ship design? The most brilliant solution cannot be called a success if it is something that nobody desires. Nonetheless, if a solution can in principle fulfill customer’s needs but it is not appropriately executed, it is a failure as well. Therefore, for a successful solution, both elements are crucial:
getting the right design and getting the design right. Respectively they answer the question “ what is the right thing to build and why?” and “how do we build it?”. The traditional design method, represented by the “design spiral”, is a solution-oriented approach that works well when requirements have already been defined. It surely provides a feasible ship possibly fulfilling the customer’s requirements, but it is not
ascertained a priori that it is the best one from all points of view. The exploration of the problem domain, necessary to select the more appropriate design, can be
achieved with a problem-oriented approach such as Systems Engineering (SE) methodology. SE aims is to identify the best possible solution that satisfies customer needs in the most efficient and effective way. In this paper, a new approach that merges the traditional ship design procedure with the Systems Engineering (SE) processes will be discussed, with a special focus on the conceptual integration between the SE V-model and the design spiral. In this perspective, it will be necessary to discuss the definitions of Measures of Performance (MOPs) and Measures of Effectiveness (MOEs). MOEs are related to the achievement of the
mission in the intended operational environment, while MOPs characterize the physical attributes of system/ subsystems. The aim is to open a discussion within
the naval architects community to define an innovative methodology that will support the decisional process in finding the best possible solution, in the specific
domain of naval ships
Integrating the analytic network process (ANP) and the driving force-pressure-state-impact- responses (DPSIR) model for the sustainability assessment of territorial transformations
No full textPurposeThe paper, which is based on an integrated approach that is able to aid the comprehension of complex phenomena, aims to investigate innovative models and tools in the field of sustainability assessment of territorial transformations. The model has been applied to a real case study related to the choice of alternative projects for the requalification of a downgraded urban area in Turin (Italy).Design/methodology/approachThe work proposes the use of a comprehensive key environmental indicator framework and multi‐criteria analysis to evaluate the sustainability of different strategies. The evaluation has been performed through the application of the analytical network process (ANP) and by means of a set of indicators, which have been arranged according to the Driving Force‐Pressure‐State‐Impact‐Responses (DPSIR) framework. The assessment model provides priority lists of the importance of the considered indicators and alternatives. All the analysis elements are modelled with the ANP, taking into consideration the interconnections between the indicators and their respective cumulative importance.FindingsAccording to the aim of the paper, the most important element in the performed analysis refers to the variation of the well‐being of the population, followed by the changes in the accessibility and attractiveness of the area, then by the effects on the real estate market and the presence of new cycle tracks.Originality/valueThe work is the first study at a national level and one of the first applications at an international level in research concerning the use of the DPSIR framework integrated with an ANP analysis.</jats:sec
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