2,918 research outputs found
"Aleukemic" granulomatous leukemia cutis
No full textAleukemic leukemia cutis is a rare condition characterized by the infiltration of the skin by leukemic cells before their appearance in the peripheral blood. The authors report a case of aleukemic leukemia cutis in a 30-year-old seemingly healthy man who presented with multiple skin papulonodular lesions and lack of peripheral blood involvement. Histopathologically, the skin infiltrates showed prominent granulomatous features that masked the underlying malignant process. Immunophenotypic studies of skin and bone marrow infiltrates revealed the myelomonocytic lineage of the atypical cells, consistent with M4 acute myelomonocytic leukemia. The authors emphasize the value of immunohistochemical studies in diagnosing a cutaneous atypical infiltrate and discuss problems of histopathologic differential diagnosis
Systemic polychemotherapy in the treatment of primary cutaneous lymphomas: a clinical follow-up study of 81 patients treated with COP or CHOP
No full textThe efficacy of systemic polychemotherapy in the treatment of primary cutaneous B-cell lymphomas (CBCL) or T-cell lymphomas (CTCL) is still controversial. A series of 81 patients (46 primary CBCL and 35 CTCL) were treated with COP or CHOP regimens. In primary CBCL, the overall objective response rate (RR) was 98%, with an 89% CR rate and a 33% relapse-rate. Five-year disease-free survival was 70%, 5-year survival 97%. Patients with leg or widespread lesions showed a higher relapse-rate (55% vs 26%) than those with trunk or head lesions. The overall objective RR was 40% in CTCL patients, with a 23% CR rate; median response duration was 5.7 months, median survival 19 months. The results confirm both the good prognosis of primary CBCL and the efficacy of polychemotherapy. CHOP regimen is to be preferred to COP in as much as it reduces relapse rates. Conversely, there are no indications for the use of COP/CHOP regimens as first-line chemotherapy in CTCL patients
KISS1 Methylation and Expression as Tumor Stratification Biomarkers and Clinical Outcome Prognosticators for Bladder Cancer Patients
No full textSupported by a grant (SAF2009-13035 to M.S.-C.) from the Spanish Ministry of Science and Innovation.Cebrian, V., Fierro, M., Orenes-Piero, E., Grau, L., Moya, P., Ecke, T., Alvarez, M., Gil, M., Algaba, F., Bellmunt, J., Cordon-Cardo, C., Catto, J., López-Beltrán, A., Sánchez-Carbayo, M
Reciprocal modulation of circulating CD4+CD25+bright T cells induced by extracorporeal photochemotherapy in cutaneous T-cell lymphoma and chronic graft-versus- host-disease patients.
No full textThe mechanisms of action of extracorporeal photochemotherapy (ECP) in cutaneous T-cell lymphoma (CTCL) are poorly understood. Recently, ECP has been shown to induce an increase in regulatory T cell (Treg) expression and functional activities in Graft-versus-host-disease (GvHD), whereas no data are available in CTCL patients. The aim of this study is to evaluate whether ECP is able to modulate the expression levels of the circulating CD4+CD25+bright subset in CTCL patients and whether these modifications are related to the disease course. The patient population included 43 CTCL and 15 chronic GvHD patients treated by ECP at our institutions since 1992. The expression of the circulating CD4+CD25+bright subset was analysed at baseline and sequentially during treatment by flow-cytometry. Fifty healthy donors were used as controls. The baseline circulating CD4+CD25+bright percentage values in CTCL (median: 4.3 percent) were similar to those of healthy donors, whereas GvHD showed significantly lower values (median: 1.5 percent; p<0.001). During treatment, CTCL patients were characterised by an early decrease (from 4.3 percent to 2.4 percent median after 6 months). The CD4+CD25+bright decrease was associated to the disease course, as it occurred in 91.3 percent of responding but in only 25 percent of PD patients (p=0.0001). On the other hand, a significant increase of CD4+CD25+bright cells was observed in GvHD. ECP induces a reciprocal modulation of the circulating CD4+CD25+bright cells in CTCL and GvHD, with a downregulation in CTCL potentially associated with the response mechanisms
Abbasid Rulers and their Standing as Authors
No full textThis chapter looks at how 3rd/9th and 4th/10th century historical and literary sources assess Abbasid rulers as scholars, poets and authors, and whether and how such assessment is tied to their legitimacy. Starting from the authors and works recorded in the Kitāb al-fihrist by Ibn al-Nadīm (d. 380/990) and surveying works of adab and historiography, the chapter reviews the production of specific caliphs and rulers, investigating several questions: whether a ruler’s works are assessed with the same criteria as other scholars’; whether there are subjects which are deemed more appropriate for a ruler to master and write about than others; whether prose and poetry are valued differently; how rulers’ written works were collected and preserved; and whether being an author, as opposed to being learned, is linked explicitly to being a better ruler. Notwithstanding the importance of culture for good rulership, is there a difference between admiring scholars and poets, learning from them, and being one
IL-2 gene-transduced human HLA-A2 melanoma cells can generate a specific antitumor cytotoxic T-lymphocyte response.
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Immune Check Point Inhibitors in Primary Cutaneous T-Cell Lymphomas: Biologic Rationale, Clinical Results and Future Perspectives
No full textPrimary cutaneous T-cell lymphomas (PCTCL) are the most common types of cutaneous lymphomas, with Mycosis fungoides as the most frequent subtype. Besides early stages which usually have a good prognosis, advanced stages remain a great therapeutic challenge with low survival rates. To date, none of the currently available therapeutic options have significantly improved the outcomes of advanced cutaneous lymphomas. Recent studies have demonstrated that immune-checkpoint molecules, such as PD-1 and CTLA-4, play part in the proliferation pathways of neoplastic T-cells, as well as in other tumors. Hence, the potential role of immune-checkpoint-inhibitors in treating cutaneous lymphomas has been investigated in the last years. Herein, we outline the current knowledge regarding the role of immune-checkpoint molecules in PCTCL, their signaling pathways, microenvironment and therapeutic inhibition rationale. Moreover, we review the published data on immunotherapies in PCTCL and summarize the currently ongoing clinical trials in this field
Nonlinear thermosonics and laser vibrometry for barely visible impact damage of a composite stiffener panel
No full textTwo methods have been evaluated in order to locate barely visible impact damage (BVID) in a composite stiffener panel. A nonlinear thermosonics technique and a nonlinear laser vibrometer technique were evaluated. Damaged regions were excited using a piezo shaker in both methods. Evaluation of the damaged regions was done by first determining the second and third order nonlinear harmonic response of the damaged regions. This was then used to determine the excitation frequency. By evaluating the presence of nonlinear responses in the output signal it is possible to excite the damaged structure at frequencies that give high heat generation and high displacements at the damaged regions. The results showed that both methods can be used to locate damaged regions, although it was shown that the stiffener impedes the propagation of the exciting wave and that these tests should be carried out in-between stiffeners in order to maximise the excitation and heating of damaged regions. Furthermore, both methods allowed for excitation of damaged regions over a large area
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