6,950 research outputs found
Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase
No full textSupernumerary centrioles are frequently observed in diverse types of cancer cells. In this study, we investigated the mechanism underlying the generation of supernumerary centrioles during the M phase. We generated the TP53;PCNT;CEP215 triple knockout (KO) cells and determined the configurations of the centriole during the cell cycle. The triple KO cells exhibited a precocious separation of centrioles and unscheduled centriole assembly in the M phase. Supernumerary centrioles in the triple KO cells were present throughout the cell cycle; however, among all the centrioles, only two maintained an intact composition, including CEP135, CEP192, CEP295 and CEP152. Intact centrioles were formed during the S phase and the rest of the centrioles may be generated during the M phase. M-phase-assembled centrioles lacked the ability to organize microtubules in the interphase; however, a fraction of them may acquire pericentriolar material to organize microtubules during the M phase. Taken together, our work reveals the heterogeneity of the supernumerary centrioles in the triple KO cells.Y
Faith in Hebrews: Analysis within the Context of Christology, Eschatology, and Ethics
No full textVictor (Sung-Yul) Rhee argues that faith in Hebrews is both Christologically and eschatologically oriented. In response to the assertion that faith in Hebrews is removed from Christ, he contends that the author of Hebrews portrays Jesus as both the model and object of faith. Rhee also maintains that the eschatological outlook in Hebrews is not the Hellenistic concept of visible and invisible reality, but the temporal orientation of present and future. The ethical aspects of faith must be interpreted within the context of Christology and eschatology to have a proper understanding of faith in Hebrews.https://digitalcommons.biola.edu/faculty-books/1524/thumbnail.jp
Modeling of high speed erosion with a morphological updating routine
No full textErosion is a phenomenon present in several industrial processes. In dredging, the jetting of sand in drag heads erodes the sand bed. In construction of offshore infrastructure such as wind turbines, oil and gas production units, marine pipelines, erosion of material near the foundations can put the stability of structures at stake. Furthermore, rivers or even tsunamis are some of the natural phenomena that can be the cause of erosion. C. van Rhee, 2007 and Bisschop et al., 2015, distinguished two regimes for the erosion of sand dependent on the fluid velocity. On one hand, for low flow velocities, 0.5-1m/s, the erosion process is dependent on the size and the density of the sand grains. On the other, for flow velocities >1.5 m/s, the upper layers of sand are sheared. Densely packed sand has a dilatant behaviour to shearing (see image). This dilatant behaviour leads to a drop of pressure in the interior of the sand-bed, creating a hydraulic gradient and forcing water to flow towards the interior of the sand-bed to fill the voids. The hydraulic gradient caused by the drop in pressure acts against the eroding forces adding resistance to the erosion process. This regime is defined as hindered erosion. The improvements in computing power have led to a spread in the use of numerical modelling for industrial purposes. The aim of this thesis is to develop a numerical solver able to model the behaviour of sand-water mixtures with an emphasis on the erosive process. The numerical model was developed in C++ using the Foam-extend 3.2 framework. The sand is modelled using 2 different approaches. It is modelled as a continuum when in suspension and, through the morphological updating routine when settled in a sand-bed. The fluid motion is modelled by a transient incompressible fluid solver (P.I.S.O) using a collocated arrangement of the unknowns. The momentum exchange between suspended sand grains and the fluid is approached by the Boussinesq approximation of the density. The transport of suspended sand is modelled by an advection-diffusion relation, including the hindered settlement effect. The turbulence model is a standard k-ε model. The erosion process is here modelled using the pick-up flux approach (van Rijn, 1984), with a modified stability criterion (θ_cr). X. Lui, 2008 and N. Jacobsen, 2011, corrected the stability criterion calculated from the sand grain properties (θ_(cr,0)) to include the slope effect (θ_slope). For this work, and following the formulation proposed by van Rhee, 2007, the stability criterion will be corrected to include the resistance due to the dilatant behaviour presented previously in this abstract (θ_vR). θ_cr=θ_(cr,0) (θ_slope+θ_vR ) The solver developed was used in two test cases. First, a settling test, with an initial concentration of sand of c=0.3. For this model, the solver shows a good behavior modeling the settling of sediment, nevertheless, the settling velocity is slightly higher than the one seen in the test. In the high speed erosion test, the velocity above the bed varies from 0-6 m/s. The fitting parameter of this model is the bed roughness; which for this test is 1.05 cm. The bed roughness (ks) was fitted to have the same erosion time. The calculated sand-bed height has values similar to the experimental results. The conservation of sediment presents satisfactory results as the error is lower than 1%, for the settling and the erosion test case. The automatic mesh motion presents certain limitations in this specific application. In the settling case an important shrinking of the mesh will lead to instabilities in the calculations of other fields. In the erosion test, the upper row of cells is greatly deformed sacrificing accuracy near the upper boundary. The mesh deformation should be explored more in depth in further studies.Mechanical, Maritime and Materials EngineeringMarine and Transport TechnologyOffshore and Dredging Engineerin
AN APPLICATION OF THE LAGRANGEAN RELAXATION METHOD TO UNIT COMMITMENT SCHEDULING IN A POWER-GENERATION SYSTEM WITH PUMPED-STORAGE UNITS
No full textThe Lagrangean relaxation method is applied to the unit commitment problem of a power generation system with pumped-storage units. The shortest path algorithm is used for the subproblem for each thermal unit and the minimal cost flow algorithm is used for each pumped-storage unit. A method for finding a better feasible solution from a solution of a relaxed problem is presented. A real Korean power generation system with 39 thermal units and one pumped-storage unit is tested. We considered 168 planning hours and we were able to find a near optimal solution (within 0.5% of optimal) consuming a reasonable amount of CPU time
Authoritarian Regimes of Rhee Syng-man and Park Chung-hee
No full textThis Bachelor's thesis entitled "Authoritarian Regimes of Rhee Syng-man and Park Chung-hee" aims to provide a comparative study of authoritarian regimes of the first two South Korean presidents, and their respective impact on the political system and society of South Korea. With the help of diachronic comparison methods, the author of this thesis focuses on the reasons behind the leaders' choice of regime, as well as on the overall changes in the form of government in South Korea which took place since the division of the Korean Peninsula until the end of the seventies
Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.
No full textA procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis. A close association of the centriole pair is regarded as an intrinsic block to the centriole reduplication. Therefore, deregulation of this process may cause a problem in the centriole number control, resulting in increased genomic instability. Despite its importance for faithful centriole duplication, the mechanism of centriole separation is not fully understood yet. Here, we report that centriole pairs are prematurely separated in cells whose cell cycle is arrested at M phase by STLC. Dispersal of the pericentriolar material (PCM) was accompanied. This phenomenon was independent of the separase activity but needed the PLK1 activity. Nocodazole effectively inhibited centriole scattering in STLC-treated cells, possibly by reducing the microtubule pulling force around centrosomes. Inhibition of PLK1 also reduced the premature separation of centrioles and the PCM dispersal as well. These results revealed the importance of PCM integrity in centriole association. Therefore, we propose that PCM disassembly is one of the driving forces for centriole separation during mitotic exit
A Simple M-branch Diversity Receiver Model for PMD-induced Penalty Mitigation in IM-DD Optical Transmission Systems
No full textWe propose a novel M-branch diversity receiver for PMD mitigation in an intensity-modulated direct-detection (IM-DD) optical transmission system. The receiver diversity is realized in the optical domain by means of a few additional fixed optics, whereas the dispersion penalty is mitigated in the electrical domain after optical-to-electrical conversion by incorporating a normalized-threshold generalized selection and combining (NT-GSC) diversity technique, which has gained a lot of attention more recently. The major motivation behind the proposition of this scheme is not to authorize a substantial increase in the receiver complexity, yet attaining a significant gain. Numerical results show that even without deploying any costly optics/
electronics, complex electronic equalizer, or an unrealistic dynamic polarization controller, the proposed scheme exhibits a reasonable improvement in PMD tolerance of about 1.7 times over a conventional IM-DD receiver at an optical signal-tonoise
ratio (OSNR) penalty of 1 dB for a bit error rate (BER) of 103 in 40 Gb/s transmission scenario, when the number of diversity branches of M = 3. Furthermore, we show that the NTGSC scheme can contribute to reduce noise in the resultant signal, which enables to achieve a gain of 1.2 dB in the case of a back-to-back transmission. In addition, we demonstrate by a simulation study that a supplementary gain can be attainable by further increasing the number of diversity branches, which will increase the cost and complexity of the proposed receiver
sj-pdf-1-han-10.1177_15589447211044786 – Supplemental material for Comparison of Patient Perception and Satisfaction of Face-to-Face Versus Telemedicine Encounters in Hand Surgery
No full textSupplemental material, sj-pdf-1-han-10.1177_15589447211044786 for Comparison of Patient Perception and Satisfaction of Face-to-Face Versus Telemedicine Encounters in Hand Surgery by John J. Bartoletta, Katharine M. Hinchcliff and Peter C. Rhee in HAND</p
Effect of molybdenum electrode annealing on the interface properties between metal and pentacene
No full textContact resistance between molybdenum (Mo) electrode and pentacene was studied with transmission line method (TLM). The Mo electrodes were annealed at 200 degrees C, 400 degrees C, 600 degrees C and 800 degrees C for 1 h and pentacene layer of 300 angstrom thickness was vacuum deposited on patterned Mo to form Mo-pentacene contact. Current-voltage measurement for Mo-pentacene contact showed linear relationship and it was confirmed that ohmic contact was formed. XRD and AFM measurements showed that Mo could be crystallized at annealing temperatures above 600 degrees C. 800 degrees C annealed Mo showed larger grains and work function was increased from 4.60 eV to 4.80 eV due to the decrease in defect density. The contact resistance was reduced down to 11.2 M Omega cm from 37.8 M Omega cm of as-deposited Mo. Also the pentacene film deposited on annealed Mo was denser with better crystallinity. Bottom contact organic field-effect transistor made with 800 degrees C annealed Mo showed better performance than as deposited Mo. (C) 2008 Elsevier B.V. All rights reserved.X118sciescopu
Electrochemical properties of porous carbon black layer as an electron injector into iodide redox couple
No full textElectrochemical properties of carbon black (CB) porous layer as a counter electrode in dye-sensitized solar cells (DSC) are studied. CB electrode for triiodide (I-3(-)) ion reduction is coated with spray coating method on the fluorine-doped tin oxide glass at 120 degrees C. The CB particle size is varied from 20 nm to 90 nm and the CB electrode thickness is controlled from 1 mu m to 9 mu m by controlling the spraying time. The electrochemical impedance spectroscopy is analyzed for a symmetric cell and a new circuit model is applied to identify electrochemical parameters. As the CB particle size is decreased, the catalytic activity is improved because of the increase in the surface area and the conductivity of the CB layer. Increased CB electrode thickness also improves the catalytic activity and leads to the low charge transfer resistance at the electrolyte/CB electrode interface. The CB counter electrode with the particle size of 20 nm and the thickness of 9 mu m for DSC shows the energy conversion efficiency of 7.2% with the highest fill factor (FF) of 65.6%. which is similar to the Pt counter electrode with FF of 65.8% and the efficiency of 7.6%. (C) 2012 Elsevier Ltd. All rights reserved.X113837sciescopu
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