220 research outputs found
Pour une histoire sociale de l'Algérie colonisée, Paris, Centre d'histoire sociale, 2014-2015
No full textSéminaire organisé par Emmanuel Blanchard et Sylvie Thénault avec le soutien du CESDIP (UMR 8183) et du CHS (UMR 8058). Les séances ont lieu dans la bibliothèque du Centre d’histoire sociale, 9 rue Malher, 6e étage (m° Saint-Paul), un mercredi par mois (deux séances en juin), de 17h30 à 19h30. Mercredi 15 octobre Soraya Laribi (U. Paris-Sorbonne), Les disparus d'Algérie après les accords d'Evian : entre problématiques mémorielles et historiques. Mercredi 12 novembre Martin Messika (U. P..
Functional mitral regurgitation in patients with aortic stenosis: prevalence, clinical correlates and pathophysiological determinants: a quantitative prospective study.
No full textAIMS: In patients with aortic stenosis (AS) functional mitral regurgitation (FMR) is frequent and is attributed to left ventricular (LV) remodelling and to aortic gradient. However, the association of these variables with mitral effective regurgitant orifice (ERO) is still unknown. METHODS AND RESULTS: We prospectively enrolled patients with aortic valve thickness and aortic velocities >2.5 m/s. We measured the LV diastolic (LVD) and systolic volumes (Simpson's method) and ejection fraction (EF) and longitudinal shortening (S-DTI), early, and late (A-DTI) lengthening velocities. The aortic valve area (AVA) and mean gradient (MG) were measured. FMR was considered in the absence of any alteration of mitral leaflet. ERO and regurgitant volume were measured by means of a proximal velocity surface area method method. One hundred and seventy-two patients formed the study population (mean age 76 ± 8 years; 50% female, EF 57 ± 14%, AVA 1.00 ± 0.4 cm(2)). Sixty-three per cent of patients had FMR (ERO range: 0.02 0.32 cm(2)). ERO was significantly associated with LVD (rho = 0.34; P = 0.0001), EF (r(s) = -0.35: P = 0.0001), and S-DTI (r = -0.57; P = 0.0001), A-DTI (rho = -0.47; P = 0.0001). In the subgroup of patients with a preserved EF (LVD 55%), S-DTI, and A-DTI were the variables with the more powerful association with ERO (r(s) = -0.49 P = 0.0001 and r(s) = -0.40 P = 0.0001, respectively). In the overall population there was a non-significant negative association between the degree of AS and ERO (MG: r(s) = -0.08 P = 0.2 and AVA: r(s) = -0.08 P = 0.2).CONCLUSION: In AS patients, the LV function is a main determinant of FMR even if EF is preserved. The association between ERO and valvular gradient is complex but tended to be negative
Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis
No full textObjective Contemporary data on patients with previously undiagnosed severe aortic stenosis (AS) are scarce. We aimed to address this gap by gathering data from consecutive patients diagnosed with severe AS on echocardiography. Methods This was a prospective, multicentre, multinational, registry in 23 tertiary care hospitals across 9 European countries. Patients with a diagnosis of severe AS were included using echocardiography (aortic valve area (AVA) <1 cm 2, indexed AVA <0.6 cm 2 /m 2, maximum jet-velocity (V max) >4 m/s and/or mean transvalvular gradient >40 mm Hg). Results The 2171 participants had a mean age of 77.9 years and 48.0% were female. The mean AVA was 0.73 cm 2, V max 4.3 m/s and mean gradient 47.1 mm Hg; 62.1% had left ventricular hypertrophy and 27.3% an ejection fraction (EF) <50%. 1743 patients (80.3%) were symptomatic (shortness-of-breath 91.0%; dizziness 30.2%, chest pain 28.9%). Patients had a EuroSCORE II of 4.0; 25.3% had a creatinine clearance <50 mL/min, and 3.2% had an EF <30%. Symptomatic patients were older and had more comorbidities than asymptomatic patients. Despite European Society of Cardiology 2017 valvular heart disease guideline class I recommendation, in only 76.2% a decision was made for an intervention (transcatheter 50.4%, surgical aortic valve replacement 25.8%). In asymptomatic patients, 57.7% with a class I/IIa indication were scheduled for a procedure, while 36.3% patients without an indication had their valve replaced. Conclusions The majority of patients with severe AS presented at an advanced disease stage. Management of severe AS remained suboptimal in a significant proportion of contemporary patients with severe AS. Trial registration number NCT02241447;Results
First-in-Man Transseptal Implantation of a "Surgical-Like" Mitral Valve Annuloplasty Device for Functional Mitral Regurgitation
No full textEffect of Transcatheter Mitral Annuloplasty With the Cardioband Device on 3-Dimensional Geometry of the Mitral Annulus.
No full textJean-Henri Maubert de Gouvest (1721-1767) et l'univers des aventuriers des lettres au siècle des Lumières
No full textJean-Henri Maubert de Gouvest, born in Rouen in 1721, was an Enlightenment adventurer. With his tumultuous career, he is fully in line within the polymorphous and variegated family of fortune knights studied by Suzanne Roth and Alexandre Stroev. In fact, by breaking relationships with his family, Maubert entered the Capuchin order at the age of 17 but when he quit the religious habit, he left the convent. Becoming fugitive, he could not return to his family and his peregrinations carried him all over Europe, like Ange Goudar or Casanova. Throughout his travels, our knight of fortune played the role of tutor in Poland, journalist in the United Provinces or spy for France. Different occupations evoked in André Warzée, Jeroom Vercruysse, Pierre Coquelle or Edmond Dziembowski’s works on the press and the Seven Years' War. By developing relationships with some statesmen and many other adventurers over the course of his adventures, Maubert created a real network and thus shaped enough material to write, gradually becoming an “aventurier d’écritoire”. His low income placed him in the category of "Rousseau des ruisseaux", analyzed by Robert Darnton. Living precariously, Maubert succeeded in attracting the good graces of a patron : Cobenzl, a plenipotentiary minister in Brussels with whom he maintained a correspondence. Despite the help of his benefactor, Maubert was forced to produce a literature only to survive, offering his readers an original vision of the eighteenth century filtered through his own experience. Polygraphe, he was interested in education, politics, religion and rewrote some of Voltaire’s works. Nevertheless, his literary career ended fairly quickly. Forced to leave Brussels for Amsterdam where his creditors caught up with him, he was imprisoned for nearly eighteen months during his endless trial. Leaving prison in a deplorable state of health, Maubert died in 1767, in Altona, in troubling circumstances. His literary work, unknown today, is however rich, including about thirty titles and would benefit being rediscovered by the historians. Thus, by analyzing the specificity of Maubert's network, we are interested in establishing whether and in what way, the different members of this group are representative and vectors of Enlightenment ideas. More than a rehabilitation of the literary artwork or of the author, we focus in this work on the study of the relationships and writings of a man who was both a witness and an actor of the Enlightenment.Jean-Henri Maubert de Gouvest, né à Rouen en 1721, est un aventurier des Lumières. Son parcours tumultueux l’inscrit pleinement au sein de la famille polymorphe et bigarrée des chevaliers de fortune étudiée par Suzanne Roth et Alexandre Stroev. De fait, rompant les relations avec sa famille, Maubert entre chez les Capucins dès l’âge de 17 ans mais envoie rapidement son froc aux orties et s’échappe du couvent. Fugitif, il ne peut retourner auprès des siens et ses pérégrinations le portent alors à travers toute l’Europe, à l’instar d’Ange Goudar ou de Casanova. Au gré de ses voyages, notre chevalier de fortune joue le rôle de précepteur en Pologne, de journaliste aux Provinces-Unies ou d’espion pour le compte de la France, différents métiers évoqués par André Warzée, Jeroom Vercruysse, Pierre Coquelle ou Edmond Dziembowski, dans leurs travaux respectifs sur la presse et la guerre de Sept Ans. Développant des relations avec certains hommes d'Etat et de nombreux autres aventuriers au fil de ses péripéties, Maubert se constitue un véritable réseau et concentre entre ses mains de la matière pour écrire, se muant peu à peu en aventurier d’écritoire. Ses faibles revenus et son mode de subsistance le placent alors plutôt dans la catégorie des « Rousseau des ruisseaux » analysée par Robert Darnton. Vivant d’expédients, Maubert réussit à s’attirer les bonnes grâces d’un mécène : Cobenzl, ministre plénipotentiaire à Bruxelles avec lequel il entretient une correspondance. Malgré l’aide de son bienfaiteur, Maubert est contraint de produire une littérature alimentaire offrant à ses lecteurs une vision originale du XVIIIe siècle filtrée par son parcours personnel. Polygraphe, il s’intéresse à l’éducation, à la politique, à la religion et réécrit certains ouvrages de Voltaire. Sa carrière de littérateur s’achève néanmoins assez rapidement. Contraint de quitter Bruxelles pour Amsterdam où ses créanciers le rattrapent, il est emprisonné pendant près de dix-huit mois et se retrouve pris dans la tourmente d’un interminable procès. Sorti de prison dans un état de santé déplorable, Maubert meurt en 1767, à Altona, dans des circonstances troublantes. Son œuvre littéraire, aujourd’hui méconnue, est pourtant riche d’une trentaine de titres et gagnerait à être redécouverte par les historiens. Ainsi, en analysant la spécificité de ce réseau satellisé autour de Maubert, il nous intéresse d'établir si et, le cas échéant, de quelle manière, les différents membres de ce groupe sont représentatifs et vecteurs des idées des Lumières. Plus qu’une simple réhabilitation de l’œuvre ou de l’auteur, nous nous attachons dans ce travail à étudier les relations et les écrits d’un homme qui est à la fois témoin et acteur du siècle
Jean-Henri Maubert de Gouvest (1721-1767) and the universe of adventurers of letters in the Enlightenment
No full textJean-Henri Maubert de Gouvest, né à Rouen en 1721, est un aventurier des Lumières. Son parcours tumultueux l’inscrit pleinement au sein de la famille polymorphe et bigarrée des chevaliers de fortune étudiée par Suzanne Roth et Alexandre Stroev. De fait, rompant les relations avec sa famille, Maubert entre chez les Capucins dès l’âge de 17 ans mais envoie rapidement son froc aux orties et s’échappe du couvent. Fugitif, il ne peut retourner auprès des siens et ses pérégrinations le portent alors à travers toute l’Europe, à l’instar d’Ange Goudar ou de Casanova. Au gré de ses voyages, notre chevalier de fortune joue le rôle de précepteur en Pologne, de journaliste aux Provinces-Unies ou d’espion pour le compte de la France, différents métiers évoqués par André Warzée, Jeroom Vercruysse, Pierre Coquelle ou Edmond Dziembowski, dans leurs travaux respectifs sur la presse et la guerre de Sept Ans. Développant des relations avec certains hommes d'Etat et de nombreux autres aventuriers au fil de ses péripéties, Maubert se constitue un véritable réseau et concentre entre ses mains de la matière pour écrire, se muant peu à peu en aventurier d’écritoire. Ses faibles revenus et son mode de subsistance le placent alors plutôt dans la catégorie des « Rousseau des ruisseaux » analysée par Robert Darnton. Vivant d’expédients, Maubert réussit à s’attirer les bonnes grâces d’un mécène : Cobenzl, ministre plénipotentiaire à Bruxelles avec lequel il entretient une correspondance. Malgré l’aide de son bienfaiteur, Maubert est contraint de produire une littérature alimentaire offrant à ses lecteurs une vision originale du XVIIIe siècle filtrée par son parcours personnel. Polygraphe, il s’intéresse à l’éducation, à la politique, à la religion et réécrit certains ouvrages de Voltaire. Sa carrière de littérateur s’achève néanmoins assez rapidement. Contraint de quitter Bruxelles pour Amsterdam où ses créanciers le rattrapent, il est emprisonné pendant près de dix-huit mois et se retrouve pris dans la tourmente d’un interminable procès. Sorti de prison dans un état de santé déplorable, Maubert meurt en 1767, à Altona, dans des circonstances troublantes. Son œuvre littéraire, aujourd’hui méconnue, est pourtant riche d’une trentaine de titres et gagnerait à être redécouverte par les historiens. Ainsi, en analysant la spécificité de ce réseau satellisé autour de Maubert, il nous intéresse d'établir si et, le cas échéant, de quelle manière, les différents membres de ce groupe sont représentatifs et vecteurs des idées des Lumières. Plus qu’une simple réhabilitation de l’œuvre ou de l’auteur, nous nous attachons dans ce travail à étudier les relations et les écrits d’un homme qui est à la fois témoin et acteur du siècle.Jean-Henri Maubert de Gouvest, born in Rouen in 1721, was an Enlightenment adventurer. With his tumultuous career, he is fully in line within the polymorphous and variegated family of fortune knights studied by Suzanne Roth and Alexandre Stroev. In fact, by breaking relationships with his family, Maubert entered the Capuchin order at the age of 17 but when he quit the religious habit, he left the convent. Becoming fugitive, he could not return to his family and his peregrinations carried him all over Europe, like Ange Goudar or Casanova. Throughout his travels, our knight of fortune played the role of tutor in Poland, journalist in the United Provinces or spy for France. Different occupations evoked in André Warzée, Jeroom Vercruysse, Pierre Coquelle or Edmond Dziembowski’s works on the press and the Seven Years' War. By developing relationships with some statesmen and many other adventurers over the course of his adventures, Maubert created a real network and thus shaped enough material to write, gradually becoming an “aventurier d’écritoire”. His low income placed him in the category of "Rousseau des ruisseaux", analyzed by Robert Darnton. Living precariously, Maubert succeeded in attracting the good graces of a patron : Cobenzl, a plenipotentiary minister in Brussels with whom he maintained a correspondence. Despite the help of his benefactor, Maubert was forced to produce a literature only to survive, offering his readers an original vision of the eighteenth century filtered through his own experience. Polygraphe, he was interested in education, politics, religion and rewrote some of Voltaire’s works. Nevertheless, his literary career ended fairly quickly. Forced to leave Brussels for Amsterdam where his creditors caught up with him, he was imprisoned for nearly eighteen months during his endless trial. Leaving prison in a deplorable state of health, Maubert died in 1767, in Altona, in troubling circumstances. His literary work, unknown today, is however rich, including about thirty titles and would benefit being rediscovered by the historians. Thus, by analyzing the specificity of Maubert's network, we are interested in establishing whether and in what way, the different members of this group are representative and vectors of Enlightenment ideas. More than a rehabilitation of the literary artwork or of the author, we focus in this work on the study of the relationships and writings of a man who was both a witness and an actor of the Enlightenment
IMPULSE: The impact of gender on the presentation and management of aortic stenosis across Europe
No full textAims There is an increasing awareness of gender-related differences in patients with severe aortic stenosis and their outcomes after surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI). Methods Data from the IMPULSE registry were analysed. Patients with severe aortic stenosis (AS) were enrolled between March 2015 and April 2017 and stratified by gender. A subgroup analysis was performed to assess the impact of age. Results Overall, 2171 patients were enrolled, and 48.0% were female. Women were characterised by a higher rate of renal impairment (31.7 vs 23.3%; p<0.001), were at higher surgical risk (EuroSCORE II: 4.5 vs 3.6%; p=0.001) and more often in a critical preoperative state (7.0vs 4.2%; p=0.003). Men had an increased rate of previous cardiac surgery (9.4 vs 4.7%; p<0.001) and a reduced left ventricular ejection fraction (4.9 vs 1.3%; p<0.001). Concomitant mitral and tricuspid valve disease was substantially more common among women. Symptoms were highly prevalent in both women and men (83.6 vs 77.3%; p<0.001). AVR was planned in 1379 cases. Women were more frequently scheduled to undergo TAVI (49.3 vs 41.0%; p<0.001) and less frequently for SAVR (20.3 vs 27.5%; p<0.001). Conclusions The present data show that female patients with severe AS have a distinct patient profile and are managed in a different way to males. Gender-based differences in the management of patients with severe AS need to be taken into account more systematically to improve outcomes, especially for women
Facilitated data relay and effects on treatment of severe aortic stenosis in europe
No full textBackground: Many patients with severe aortic stenosis are referred late with advanced symptoms or inappropriately denied intervention. The objective was to investigate whether a structured communication to referring physicians (facilitated data relay) might improve the rate and timeliness of intervention. Methods and Results: A prospective registry of consecutive patients with severe aortic stenosis at 23 centers in 9 European countries with transcatheter as well as surgical aortic valve replacement being available was performed. The study included a 3-month documentation of the status quo (phase A), a 6-month intervention phase (implementing facilitated data relay), and a 3-month documentation of a legacy effect (phase-B). Two thousand one hundred seventy-one patients with severe aortic stenoses were enrolled (phase A: 759; intervention: 905; phase-B: 507). Mean age was 77.9±10.0 years, and 80% were symptomatic, including 52% with severe symptoms. During phase A, intervention was planned in 464/696 (67%), 138 (20%) were assigned to watchful waiting, 8 (1%) to balloon aortic valvuloplasty, 60 (9%) were listed as not for active treatment, and in 26 (4%), no decision was made. Three hundred sixty-three of 464 (78%) patients received the planned intervention within 3 months. Timeliness of the intervention improved as shown by the higher number of aortic valve replacements performed within 3 months (59% versus 51%, P=0.002) and a significant decrease in the time to intervention (36±38 versus 30±33 days, P=0.002). Conclusions: A simple, low-cost, facilitated data relay improves timeliness of treatment for patients diagnosed with severe aortic stenosis, resulting in a shorter time to transcatheter aortic valve replacement. This effect was mainly driven by a significant improvement in timeliness of intervention in transcatheter aortic valve replacement but not surgical aortic valve replacement. Clinical Trial Registration: URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02241447
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