346 research outputs found
[Detection of extra-articular soft-tissue involvement in rheumatoid arthritis: value of color-coded Doppler sonography]
No full textNonunion
No full textThe pathogenesis of bone healing disturbances is multifactorial, but especially related to impaired biology, inadequate stability, fracture gapping and infection. The key symptom is pain and discomfort at the site of nonunion while moving and weight-bearing the affected limb. Typical findings on conventional radiographs or CT support the diagnosis: missing progress of bone healing on serial images, loss of bridging trabecular bone crossing the fracture zone or hypertrophic bridging callus with persistent fracture gap. Breakage of implants is an additional, associated sign. Treatment principles consist of improvement of impaired biology and improvement of stability: restoration of axial alignment, stabilization of fracture fragments, reaming, intramedullary nailing with an increased nail diameter, compression of nonunion; and multiple interlocking. The authors prefer antegrade nailing with the patient in lateral position in femur diaphysis nonunion. Overreaming, exact positioning of the nail and interfragmentary compression are most important parts of the procedure. Exchange nailing is done as a closed procedure in hypertrophic nonunion of the tibia. For axis correction and in atrophic nonunion, the nonunion site is opened. Whenever an intact fibula blocks dynamization of the tibia, or compression across the tibial nonunion site, oblique fibula osteotomy and resection of a short segment is performed. Humerus nonunion after conservative treatment is treated with closed nailing, nonunion after nailing is treated with reaming, exchange nailing, compression and multiple interlocking. In metaphyseal nonunion, the use of an auxiliary plate; and in long oblique fractures, the use of cerclage wires is beneficial to secure fracture reduction during nail insertion and enhance stability of the nail-bone construct
Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
No full textFemale mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is up-regulated and spreads along the future inactive X chromosome. Contextually, it recruits repressive histone and DNA modifiers that transcriptionally silence the X chromosome. Xist regulation is tightly coupled to differentiation and its expression is under the control of both pluripotency and epigenetic factors. Recent evidence has suggested that chromatin remodelers accumulate at the X Inactivation Center (XIC) and here we demonstrate a new role for Chd8 in Xist regulation in differentiating ES cells, linked to its control and prevention of spurious transcription factor interactions occurring within Xist regulatory regions. Our findings have a broader relevance, in the context of complex, developmentally-regulated gene expression
Frequency Content of Bending Test Kinematics: A Study to Determine the Optimal Data Filtering.
No full textKlinische und histologische Untersuchungen zur Regenerationsfähigkeit des Beckenkammes nach Spongiosaentnahme
No full textStandard method for the investigation of bone transplants, ceramics, or other material in a human bony layer
No full textDas Degradationsverhalten der Calciumphosphatkeramiken Hydroxylapatit und Tricalciumphosphat im Verlauf der knöchernen Integration
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