340 research outputs found
A Nitrogen Reference Manual for the Southern Cropping Region
No full textGRDC Project Code: UA00165 – Managing legume and fertiliser nitrogen in the southern regionUnkovich MJ, Herridge DF, Denton MD, McDonald GK, McNeill AM, Long W, Farquharson R and Malcolm
Body-vehicle interaction : experimental study /
No full textDistributed by NTIS (PB 240919, 241209)Prepared by H.B. Pritz, E.B. Weis and J.T. Herridge ; Battelle Columbus Laboratories.Cover title.Final report, July 1973 to February 1975, prepared for the National Highway Traffic Safety Administration.Report no. DOT-HS-801-473.v. 1 Summary.--v.2. Technical discussion.Mode of access: Internet
Inoculating legumes: a practical guide
No full textElizabeth Drew, David Herridge, Ross Ballard, Graham O’Hara, Rosalind Deaker, Matthew Denton, Ron Yates, Greg Gemell, Elizabeth Hartley, Lori Phillips, Nikki Seymour, John Howieson and Neil Ballar
The effects of hostility and arousal on facial affect perception: a test of a neuropsychological model of hostility
No full textWithin the field of psychology, hostility has historically been a heavily researched affective construct. The purpose of this experiment was to test hypotheses derived from a neuropsychological model of hostility utilizing two common research paradigms from the extant literatures on hostility's cognitive and physiological correlates. This was accomplished by testing an integral component of a previously proposed neuropsychological model of hostility (Herridge & Harrison, 1994). The purpose of the model was to aid in understanding the chronicity and pervasiveness of a hostile disposition. The model describes a system where physiological arousal level is mediated by systems which also mediate accuracy of an individual's interpretation of affective cues. It was at this level (physiological arousal and perception) that the experimental test was developed.
It was predicted that hostile men would show different levels of perceptual accuracy than non-hostile men in both a cold pressor (CP) and no CP condition when tachistoscopically presented with three categories of affective facial configurations (happy, angry, and neutral) in either their left (LVF) or right visual field (RVF).
In this sample of college men (N = 56), a four-factor, repeated measures, analysis of variance (ANOVA) produced a significant three-way interaction which indicated that hostile subjects were less accurate than non-hostile subjects in the assessment of happy, angry, and neutral faces in their LVF. However, they were more accurate than subjects classified as non-hostile in the assessment of happy and angry facial configurations in their RVF. Subjects were classified as hostile and non-hostile using joint criteria; the Cook-Medley hostility scale (Ho) and cardiovascular reactivity levels to the arousing stimulus, a CP task.
Additionally, a non-significant trend was noted where nonhostile subjects in a no CP state showed more accuracy in the assessment of faces presented to them in their LVF than all other group and CP levels. However, they showed less accuracy than all others when faces were presented in their RVF.
These findings are discussed in regard to the proposed model of hostility. Confirmatory and contradictory evidence is discussed relative to current neuropsychological hypotheses on the lateralization of affective function in the cerebral cortex and the role of physiological arousal in affective facial perception. Clinical implications of results are further discussed in relation to anger management interventions in hostile men. Recommendations for future research on hostility, relative to design and new directions, are made.Ph. D
An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study.
No full text24.06.13 KB. Ok to add the published version to Spiral. Biomed centra
Research during an Emergency: A Series of Inquiries Concerning the Outbreak of Severe Acute Respiratory Syndrome (SARS) in Toronto
No full textBackground: Researchers and research ethics boards (REBs) in Toronto were unprepared for the SARS outbreak. There is a paucity of literature about how to review emergency-related protocols during a public emergency and so REBs had no guidance about how to review SARS-related protocols.
Research questions: The thesis presents four related research inquiries based on the following four objectives: 1) to conduct a comprehensive evaluation of the one-year outcomes in SARS survivors; 2) to explore the ethical issues that emerged during the conduct of the SARS outcomes study; 3) to understand the impact of the SARS outbreak on research ethics review (RER) of SARS-related protocols; and 4) to propose a new framework of RER for use during public emergencies.
Methods: Included in this thesis are an observational study, an analytic reflection, a grounded theory study, and a translation of the knowledge gained in the first three parts of the thesis into a framework of RER that is meaningful and actionable.
Results: Part I describes the recovery made by SARS survivors from their acute illness. In part II, I explore ethical issues that arose during the conduct of the study including: social and scientific value and scientific validity of emergency research, and respect for privacy and confidentially. Part III presents a theory about how researchers, REBs and public health interacted during the outbreak and in part IV I propose ‘emergency review’ a framework for RER for use during a publicly declared emergency.
Conclusions: The natural experiment that was the SARS outbreak in Toronto revealed the vulnerabilities in the structure of REBs. I highlight three conclusions which are the highest priority to provide further development in this field. These are: 1) when REBs, researchers and public health are not effectively communicating during a public emergency, the work of each group is disrupted; 2) institutional conflict of interest occurred during the research ethics review of SARS-related protocols and may be amplified during a public emergency and 3) there is a need for a multi-site review structure that could be activated on short notice to review protocols related to the emergency situation.Ph
Duplications upstream and downstream of SHOX identified as novel causes of Leri-Weill dyschondrosteosis or idiopathic short stature.
No full textLeri-Weill dyschondrosteosis is a pseudoautosomal dominantly-inherited skeletal dysplasia ascribed to haploinsufficiency of the SHOX gene caused by deletions, point mutations, or partial duplications of the gene, or to heterozygous deletions upstream or downstream of the intact SHOX gene involving conserved non-coding cis-regulatory DNA elements that show enhancer activity. Recently, two SHOX conserved non-coding element duplications, one upstream and one downstream, were reported in patients referred with idiopathic short stature. To further evaluate the role of these duplications in SHOX-related disorders, we describe seven patients (five with Leri-Weill dyschondrosteosis and two with short stature) all of whom have duplications of part of the upstream or downstream conserved non-coding element regions, identified by multiplex ligation-dependent probe amplification. In addition, we show data from 32 patients with an apparently identical downstream duplication that includes a proposed putative regulatory element (identified by multiplex ligation-dependent probe amplification or array comparative genome hybridization), which results in a variable phenotype from normal to mild Leri-Weill dyschondrosteosis. These additional data provide further evidence that duplications of upstream and downstream long range cis-regulatory DNA elements can result in a SHOX-related phenotype
Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial
No full textAcute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure. There are in vitro, animal studies and pre-clinical data suggesting that statins may be beneficial in ALI. The Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial is a multicenter, prospective, randomized, allocation concealed, double-blind, placebo-controlled clinical trial which aims to test the hypothesis that treatment with simvastatin will improve clinical outcomes in patients with ALI
Recommended from our members
Not all equal? Exploring secondary school pupils’ journeys, attainment and experiences in an English ‘all-through’ school
No full textIn state funded schools in England the vast majority of children transition from primary school to secondary school at the age of 11. An all-through school offers pupils primary and secondary education in one setting and therefore has the potential to offer a smoother transition experience.
Embedded within a school with pupils on both an all-through route and a non-all-through route I draw upon my experience as a researcher, teacher and senior leader to report on the pupils’ experiences of transition. This longitudinal ethnographic case study employs a mixed methods approach to compare transition experiences. By utilising a survey questionnaire, a set of pupil interviews across the transition period and the analysis of attainment data, a rich description of the pupils’ transition experience has been obtained and the two transition routes compared.
The survey questionnaire was completed in September 2023 with 132 pupils (54 all-through pupils and 78 non all-through pupils) who each answered 12 questions. 3 of these questions had multiple subquestions leading to the collection of 49 data points for each pupil and therefore 6468 data points. This data was collected with Google Forms which autogenerated a Google Sheet with raw answers. The answers and associated analysis exist as one excel (.xlsx) file titled ‘Transition Survey Data’ totalling 365KB.
Pupil interviews were completed with 10 pupils (5 all-through and 5 non-all-through) at 3 time points across the transition period (July, September and November 2024). Pupils were asked a set of questions from an interview script and the data was transcribed using Otter.ai. The transcribed data was exported to Google Sheets to be analysed. The answers and associated analysis exist as three excel (.xlsx) files titled ‘Preliminal Interview Answers,’ ‘Liminal Interview Answers,’ and ‘Postliminal Interview Answers’ which are 29KB, 18KB and 26KB respectively.
Attainment data for 143 pupils (58 all-through and 85 non-all-through) in six subjects at 3 timepoints across the academic year (October 2023, February 2023 and June 2024) was collected which totalled 7569 pieces of data. The attainment data and associated analysis exist as one excel (.xlsx) file titled ‘Year 7 Attainment Data’ totalling 49KB
Are sex ratio distorting endosymbionts responsible for mating system variation among dance flies (Diptera: Empidinae)?
No full textMaternally inherited bacterial endosymbionts are common in many arthropod species. Some endosymbionts cause female-biased sex ratio distortion in their hosts that can result in profound changes to a host's mating behaviour and reproductive biology. Dance flies (Diptera: Empidinae) are well known for their unusual reproductive biology, including species with female-specific ornamentation and female-biased lek-like swarming behaviour. The cause of the repeated evolution of female ornaments in these flies remains unknown, but is probably associated with female-biased sex ratios in individual species. In this study we assessed whether dance flies harbour sex ratio distorting endosymbionts that might have driven these mating system evolutionary changes. We measured the incidence and prevalence of infection by three endosymbionts that are known to cause female-biased sex ratios in other insect hosts (Wolbachia, Rickettsia and Spiroplasma) across 20 species of dance flies. We found evidence of widespread infection by all three symbionts and variation in sex-specific prevalence across the taxa sampled. However, there was no relationship between infection prevalence and adult sex ratio measures and no evidence that female ornaments are associated with high prevalences of sex-biased symbiont infections. We conclude that the current distribution of endosymbiont infections is unlikely to explain the diversity in mating systems among dance fly species. ©2017 Murray et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- …
