59 research outputs found
Comparison of serum glucose and salivary glucose in diabetic patients
No full textBackground and Objectives: The importance of saliva for oral health is well known. Diabetes mellitus affects the salivary gland functioning and thus alters the salivary constituents. For many years the question of the presence of glucose in saliva has been a subject of debate and only few people found correlation between serum glucose and salivary glucose in diabetics. Hence, the purpose of this study was to estimate and correlate salivary glucose concentration and serum glucose concentration in diabetics and healthy controls. Materials and Methods: 60 newly diagnosed diabetic patients and 60 age and sex matched control subjects were included in the study. Blood and saliva samples from both the groups were collected at least two hours after the breakfast. The samples were centrifuged and subjected to glucose analysis using Semiautoanalyzer (BioSystems BTS-310 Photometer). For experimental group, the samples were collected again after the control of diabetes mellitus. The statistical comparisons were performed using paired and unpaired t -test. Results: A highly significant correlation was found between salivary glucose and serum glucose before the treatment and also after the control of diabetes. The correlation between salivary glucose and serum glucose was also highly significant in controls. The levels of salivary glucose did not vary with age and sex. Conclusion and Interpretation: As there was significant correlation between salivary glucose and serum glucose, salivary glucose holds the potential of being a marker in diabetes. Further, it has an added advantage of being non-invasive procedure with no need of special equipments and with fewer compliance problems as compared with collection of blood
Oral Primary Syphilis - A Rare Case Report
No full textSyphilis is a sexually transmitted disease caused by spirochete, Treponema palladium. The incidence of syphilis has greatly increased in the past few years, though oral disease as a consequence of primary syphilis is rare. Extragenital chancres occur in about 5-10% of cases with primary syphilis and may occur as a consequence of orogenital contact. We report a case of 40 year old man, with primary syphilis, who presented with ulceration in the palate and non tender lymphadenopathy. The oral aspects of primary syphilis and the need for dentists to be aware of changing epidemiologic trends are highlighted
Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes
No full textThe embryonic rat dorsal root ganglion (DRG) neuron-derived 50B11 cell line is a promising sensory neuron model expressing markers characteristic of NGF and GDNF-dependent C-fibre nociceptors. Whether these cells have the capacity to develop into distinct nociceptive subtypes based on NGF- or GDNF-dependence has not been investigated. Here we show that by augmenting forskolin (FSK) and growth factor supplementation with NGF or GDNF, 50B11 cultures can be driven to acquire differential functional responses to common nociceptive agonists capsaicin and ATP respectively. In addition, to previous studies, we also demonstrate that a differentiated neuronal phenotype can be maintained for up to 7 days. Western blot analysis of nociceptive marker proteins further demonstrates that the 50B11 cells partially recapitulate the functional phenotypes of classical NGF-dependent (peptidergic) and GDNF-dependent (non-peptidergic) neuronal subtypes described in DRGs. Further, 50B11 cells differentiated with NGF/FSK, but not GDNF/FSK, show sensitization to acute prostaglandin E2 treatment. Finally, RNA-Seq analysis confirms that differentiation with NGF/FSK or GDNF/FSK produces two 50B11 cell subtypes with distinct transcriptome expression profiles. Gene ontology comparison of the two subtypes of differentiated 50B11 cells to rodent DRG neurons studies shows significant overlap in matching or partially matching categories. This transcriptomic analysis will aid future suitability assessment of the 50B11 cells as a high-throughput nociceptor model for a broad range of experimental applications. In conclusion, this study shows that the 50B11 cell line is capable of partially recapitulating features of two distinct types of embryonic NGF and GDNF-dependent nociceptor-like cells. Matusica Dusan, Canlas Jastrow, Martin M Alyce, Wei Yingkai, Marri Shashikanth, Erickson Andelain, Barry M Christine, Brierley M Stuart, Best G Oliver, Michael Z Michael, Voelcker H Nicolas, Keating J Damien, and Haberberger V Raine
Angiosarcoma of the mandible
No full textAngiosarcoma is a rare malignancy of vascular endothelium which may arise from either blood or lymphatic vessels. These tumors are aggressive with a tendency to recur locally and also have a high rate of lymph node and systemic metastases. Angiosarcomas occur more frequently in skin and soft tissue. Occurrence of a primary or metastatic angiosarcoma in the oral cavity is extremely rare. The purpose of this article is to document a case of primary angiosarcoma in the right mandible of a 20 year old woman. The tumor presented as a rapidly enlarging lobulated soft tissue mass which was associated with an irregular radiolytic defect in the right mandible. Histological features of the lesion were suggestive of a high grade angiosarcoma. The patient was successfully treated with a combination therapy involving surgery and chemotherapy. There were no signs of tumor recurrence or metastasis after one and a half year of follow up
Synthesis of podophyllotoxin analogues. xii. synthesis of β-apopicropodophyllin analogues
No full textABSTRACT Tetralone esters (4a–c) on hydroxy methylation with ethyl formate yielded 5a–c which on reduction with sodium borohydride followed by hydrolysis gave dihydroxy acid 8a–c. Base-catalysed cyclisation of 8a–c using p-toluene sulfonyl chloride gave β-apopicropodophyllin analogues (3a–c) in quantitative yield
Preparation of ethyl 6-methoxy-7-methyl-1-aryl/cyclohexyl-4-oxo-2-naphthoates as an intermediates for synthesis of beta-apopicropodophyllin analogues
No full textPreparation of tetralone ester 4a-c, an intermediate for the synthesis of beta -apopicropodophyllin analogues via Stobbe condensation of benzophenone derivatives followed by Friedel Craft's cyclization is described
Sintering characteristics of red mud compact
No full textIt is beyond doubt that activity of primary industries often yields substantial amounts of byproducts. The disposal in the original industrial site is favoured by economic reasons though traditional storage in nearby dumps can be impractical owing to the considerable masses involved and environmental restrictions. The local exploitation of these by-products is therefore a growing technological aspect of basic industries and one tenable option is their re-use as starting materials for other productions.This huge amount of industrial yproducts/wastes which is becoming a client for increasing environmental pollution & generation of a huge amount of unutilized resources. With a view to the above, this research is aimed at finding out utilization of such things/material/industrial byproducts for value added applications & also helps to solve the environmental problems. The present piece of my research work aims at, to provide a valued input/utilization to industrial byproduct/waste. An emblematic case is the ‘red mud’ discharged by industry producing alumina from bauxite: alkaline digestion of 2.5 t of bauxite affords alumina and ≈1.5 t of red mud ,so that an average Al2O3 productivity of 5×105 t year−1 involves a mass of by-products of ≈7.5×105 t year−1 discharged as slurry retaining variable water contents. This amount is composed of Fe and Ti oxides, behaving as chemically inert matter, with variable percentages of nominal SiO2,Al2O3 and Na2O. The material is available as a watery mixture which settles slowly and may easily be conveyed from station to station by continuous fluid-carrying machinery.The recycling of the mud, after curing or high temperature annealing — up to 1200°C — for large-rate daily mass consumption industries such as bricks and tile kilns has been put forward in a number of papers[2,3,4,5,6,7,8,9]Most of the above reports appear fragmentary and, to some extent surprising, characterization work is limited to the elemental analysis of the raw material and the identification of the crystalline phases in dried samples. However, the definition of thermal behaviour in a wide working range of temperatures appears mandatory for a feasible exploitation of the mud in high temperature applications. Indeed, the reactivity of red mud components on heating may promote ceramization and shrinkage and, apart from other qualities, may affect the mechanical features of clay-based items fabricated with bauxite-waste addition.Accordingly, we focus here on the thermal behaviour of the mud, the solid-state transformations and solid–liquid phase transitions. The use of thermal analysis coupled with of X-ray diffraction methods seemed well suitable for the problem at hand. The present study is a part of a long-term project on the exploitation of red mud as a clay additive for the ceramic industry or as a compound for self-binding mortars in the fabrication of stoneware
Poster presentation
No full textAdams, Jeffrey Q. (34); Al-Ghazzawi, Ziad (24); Alleman, James E. (10); Altuve, Juan (3); Barlaz, Morton A. (18); Bandemehr, Angela L. (11); Bandyopadhyay, Arup (32); Bandyopadhyay, Nandita (31); Bhandari, Alok (8); Blatchley, E. R. (6); Boardman, Gregory (27); Boylen, C. W. (39); Buelow, Timothy C. (5); Burgos, William D. (9); Buschart, S. P. (39); Chiang, M. K. (12); Chiou, Chung-Fan (34); Chyi, Y. T. (38); Clesceri, Lenore S. (36); Clesceri, Nicholas L. (36); Cline, A. Caroline (17); Dague, Richard R. (5, 24, 38); Davies, Simon H. R. (11, 12, 13); Day, James E. (13); Dove, Dennis C. (8); Duggirata, Ravi (6); Estevez, Elyrosa (2); Estrada, Rosalbe Melida Escalante (26); Gopalan, R. (37); Gray, Deborah B. (23); Hanna, K. Michael (27); Ho, Yi-Fong (19); Hoffman, David (23); Jewell, W. J. (30); Jones, LaDon C. (5); Kaempf, Ch. (37); Khatra, Nimrata (1); Lundberg, Ian (33); Madhukar, Burra V. (15); Mansour, Awad (24); Marin, Grace (2); Marinas, Benito J. (1, 26, 29, 34, 35); Masten, Susan J. (11, 12, 13, 14, 15, 16); McCormack, Clayton E. (11); McEwen, M. M. (39); Nakad, Fady F.(4); Ndon, Udeme J. (28); Novak, John T. (8, 9); Pascual, Beth (7); Pierce, David G. (20); Potter, Thomas G. (21) ; Rankin, J. M. (39); Rawley, Elaine (30) ; Regula, Jayadev (7); Rhew, Rodney D. (18) ; Rich, Linvil G. (23); Richards, Wilfred Sugumar (37); Saraswat, Nirmala (10); Saunders, F. Michael (4); Shahalam, Abul-Bashar (24); Shalewitz, Robert (3, 7); Shu, M. M. (12); Smith, Thomas J. (10); Smythe, William H. (36); Soracco, R. J. (39); Srinivas, Shashikanth (25); Staud, R. (37); Tansel, Berrin (2, 3, 7); Truax, Dennis D. (25); Upham, Brad L. (15); Uruma, Richard (35); Vilar, Frank (3); Wang, Ko-Ming (29); Watkins, Bruce D. (16); Watts, Randall W. (22); Whelan, Michael P. (2); Wukasch, Ronald F. (20, 33); Yao, Jehng-Jyun (14
Salivary coagulopathy and immunoglobulins in oral submucous fibrosis
No full textAim : The etiopathogenesis of oral submucous fibrosis is still obscure. Immunological disorders have been associated with it and as the disease produces changes localized to the oral cavity, it is assumed that saliva may play an important role in the etiopathogenesis. The purpose of this study was to detect salivary coagulopathy, immunologic alterations and their comparison in oral submucous fibrosis patients and controls. Materials and Methods : Salivary coagulopathy procedures and quantitative estimations of serum immunoglobulins were carried out by serial radial immunodiffusion method in 60 oral submucous fibrosis patients and equal age- and sex-matched healthy controls. The obtained data was analyzed using Mann-Whitney and Chi-square tests. Results : The results indicated the presence of a precipitating factor in saliva responsible for salivary coagulopathy, dependent upon the severity of the disease and not on age, sex or duration of the disease. As compared to the controls, serum IgG and IgA, but not IgM levels were raised significantly among patients. IgG levels were increased in all the grades, while IgA levels were increased in Grade II and Grade III cases only. IgM levels in Grade II and Grade III cases showed no significant alterations, however, were reduced in Grade I cases. The serum immunoglobulin levels showed no correlation with the duration of the disease. Conclusion : Alteration in saliva and immunity do indicate an immunological basis in the etiopathogenesis of this complex clinical entity
Synthesis of bishydrazones (aldazines)
No full textBishydrazones have been prepared by thermolysis of aldehyde hydrazone under reduced pressure in a sealed tube at 120-30 degrees C. The possible mass spectral fragmentation mode of bishydrazones have also been discussed
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